Results 41 to 50 of about 1,976,779 (394)
Dendrogenin A drives LXR to trigger lethal autophagy in cancers
Nature Communications, 2017 Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia.
Gregory Segala +34 more
doaj +1 more source
Molecules, 2019 Umbelliprenin has recently been shown to have great potential as a skin whitening agent. Wishing to investigate the same effect in plant species known to biosynthesize this coumarin, three plants belonging to the Apiaceae family, namely Anethum ...
Vito Alessandro Taddeo +9 more
doaj +1 more source
Structure of the Myelin Sheath Proteolipid Plasmolipin (PLLP) in a Ganglioside-Containing Lipid Raft
Frontiers in Bioscience-Landmark, 2023 Background: Plasmolipin (PLLP) is a membrane protein located in lipid rafts that participates in the formation of myelin. It is also implicated in many pathologies, such as neurological disorders, type 2 diabetes, and cancer metastasis.
Fodil Azzaz +5 more
doaj +1 more source
Advances in Orthopedics, 2015 In 6 patients with familial thrombophilia (5 Factor V (FV) Leiden heterozygotes, 1 with resistance to activated protein C (RAPC)), we prospectively assessed whether continuous longterm (4–16 years) anticoagulation would prevent progression of idiopathic ...
Charles J. Glueck +3 more
doaj +1 more source
Physiological Reports, 2022 Rats selectively bred for the high intrinsic aerobic capacity runner (HCR) or low aerobic capacity runner (LCR) show pronounced differences in susceptibility for high‐fat/high sucrose (HFHS) diet‐induced hepatic steatosis and insulin resistance ...
Harrison D. Stierwalt +13 more
doaj +1 more source
Vascular robustness: The missing parameter in cardiovascular risk prediction
Preventive Medicine Reports, 2018 Undetected high risk for premature death of cardiovascular disease (CVD) among individuals with low-to-moderate risk factor scores is an acknowledged obstacle to CVD prevention.
Lutz E. Kraushaar +2 more
doaj +1 more source
Cholesterol oxides inhibit cholesterol esterification by lecithin: cholesterol acyl transferase
Brazilian Journal of Pharmaceutical Sciences, 2009 Cholesterol oxides are atherogenic and can affect the activity of diverse important enzymes for the lipidic metabolism. The effect of 7β-hydroxycholesterol, 7-ketocholesterol, 25-hydroxycholesterol, cholestan-3β,5α,6β-triol,5,6β ...
Eder de Carvalho Pincinato +2 more
doaj +1 more source
Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice [PDF]
, 2010 Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease ...
Benson, G. Martin +5 more
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Which lipid measurement should we monitor? An analysis of the LIPID study [PDF]
, 2014 OBJECTIVES: To evaluate the optimal lipid to measure in monitoring patients, we assessed three factors that influence the choice of monitoring tests: (1) clinical validity; (2) responsiveness to therapy changes and (3) the size of the long-term ‘signal ...
Glasziou, Paul P. +4 more
core +1 more source
Lipids in Health and Disease, 2017 Background Nutritional modulation remains central to the management of metabolic syndrome. Intervention with cinnamon in individuals with metabolic syndrome remains sparsely researched.
Sonal Gupta Jain +4 more
doaj +1 more source