Results 81 to 90 of about 763,562 (268)

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

Cholesterol Crystals – A Beautiful Incidental Finding in Pleural Fluid

Journal of the Scientific Society
Chyliform (pseudochylous) pleural effusions build up over time as a result of the breakdown of cellular lipids in long-lasting pleural effusions such as those caused by tuberculosis and rheumatoid arthritis.
Surabhi, Avinash Singh, Tanmay Kumar, Pummi Kumari   +3 more
doaj   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Bempedoic Acid: A Novel Approach in Managing Dyslipidemia and Reducing Cardiovascular Risk

Journal of Education, Health and Sport
Cardiovascular disease remains one of the leading causes of mortality worldwide, with elevated LDL cholesterol being a critical risk factor. Statins have long been the cornerstone of lipid-lowering therapy, but many patients fail to reach target LDL ...
Łukasz Wołowiec, Małgorzata Pellowska, Michał Janiak, Lidia Wydeheft, Grzegorz Grześk, Walery Zukow   +5 more
doaj   +1 more source

Resolving Heterogeneity of Targeted Lipid Nanoparticles Through Solution‐Based Biophysical Analyses

Advanced Materials, EarlyView.
AF4‐UV‐DLS‐MALS‐SAXS resolves previously inaccessible targeted lipid nanoparticle (tLNP) subpopulations that differ in size, shape, and composition. Correlation of subpopulation‐resolved biophysical properties with in vivo RNA delivery reveals that targeted placental transfection is associated with distinct tLNP subpopulations rather than ensemble ...
Hannah C. Geisler, Hannah C. Safford, Ajay S. Thatte, Marshall S. Padilla, Elisa Battistini, Hannah M. Yamagata, Violet M. Ullman, Alex Chan, Benjamin E. Nachod, Anushka Agrawal, Maxwell B. Watkins, Jesse B. Hopkins, Andrew Tsourkas, Kushol Gupta, Michael J. Mitchell   +14 more
wiley   +1 more source

Cholesterol Pericarditis

JACC: Case Reports
Cholesterol pericarditis is a rare condition characterized by cholesterol crystal accumulation in the pericardium, often linked to hyperlipidemia and chronic inflammatory disorders.A 50-year-old woman with a history of hypercholesterolemia presented with progressive dyspnea, chest pain, and fatigue.
Mohammad Saquib Alam, Khwaja Saifullah Zafar   +1 more
openaire   +3 more sources

Navigating Lipid Nanostructure Design Space Through Continuous Microfluidic Automation

Advanced Materials, EarlyView.
LipidXplorer is a novel microfluidic platform which enables rapid navigation of lipid particle design space for high‐resolution phase mapping, lipid nanoparticle optimization, membrane biophysics, and functional nanomaterial discovery. It combines programmable composition control, continuous nanoparticle formation, and automated well‐plate collection ...
Bradley Diggines, Marcus Fletcher, Manuel Bibrowski, Karnyart Samnuan, Rongjun Chen, David J. Peeler, Amjad Abouselo, Morag R. Hunter, Molly M. Stevens, Nicholas J. Brooks, Yuval Elani   +10 more
wiley   +1 more source

Predictors of plasma HDL-C concentrations in the Coronary Artery Risk Development in Young Adults (CARDIA) study

Journal of Lipid Research
HDL-C is an established risk marker for coronary heart disease. We investigated sociodemographic, lifestyle, anthropometric/physiologic, and other predictors of HDL-C over 30 years of follow-up in the Coronary Artery Risk Development in Young Adults ...
James M. Shikany, John R. Bassler, Jared P. Reis, Pamela J. Schreiner, David T. Redden, John T. Wilkins, Cora E. Lewis   +6 more
doaj   +1 more source

A Chemical Framework for Engineering Extracellular Vesicles’ Biointerface to Advance Precision Therapeutics

Advanced Materials, EarlyView.
Extracellular vesicles (EVs) are cell‐derived nanoparticles that mediate intercellular communication through their dynamic biointerfaces. Owing to their intrinsic biological functions, EVs have emerged as promising platforms for biomedical applications.
Leila Pourtalebi Jahromi, Felix Geng, Jan‐Noël Frenzke, Gregor Fuhrmann   +3 more
wiley   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source