Results 111 to 120 of about 175 (152)

Cholesterol 24-hydroxylase overexpression in the dorsal striatum reduces relapse to cocaine-seeking

Abstract Sparse but converging evidence suggests that drug addiction is associated with alterations in the metabolism of cerebral cholesterol. Furthermore, in rats, administration of statins, inhibitors of cholesterol synthesis, reduces risks of relapse to cocaine.
Nathalie Thiriet, Stevenson Desmercières, Thomas AUPY, Youna Vandaele, Manon Gauthier, Emilie Dugast, Virginie Lardeux, Faustine Arrivet, Lucy Martine, Niyazi ACAR, Pauline Belujon, Nicolas Heck, Sandrine Betuing, Marcello Solinas, Elodie Masson   +14 more
openaire   +1 more source

Development of a Novel ¹⁸F-Labeled Radioligand for Imaging Cholesterol 24-Hydroxylase with Positron Emission Tomography

ACS Pharmacology & Translational Science
Cholesterol 24-hydroxylase (CYP46A1), also known as CH24H, is a brain-specific monooxygenase responsible for the elimination of cholesterol from the central nervous system (CNS). It catalyzes the conversion of cholesterol to 24(S)-hydroxycholesterol, the primary pathway for CNS cholesterol clearance.
Jian Rong, Chunyu Zhao, Ahmad F. Chaudhary, Jiahui Chen, Xin Zhou, Kuo Zhang, Zhendong Song, Zhenkun Sun, Yabiao Gao, Zachary Zhang, Siyan Feng, Thomas Lee Collier, Hongjie Yuan, Jimmy S. Patel, Achi Haider, Yinlong Li, Steven H. Liang   +16 more
openaire   +3 more sources

Role of cholesterol 24S-hydroxylase gene polymorphism (rs754203) in primary open angle glaucoma.

Molecular vision, 2011
The enzyme cholesterol 24S-hydroxylase (Cyp46A1) is responsible for the conversion of cholesterol to its more polar metabolite 24S-hydroxycholesterol, thereby enabling the intracerebral elimination of cholesterol. An intronic single nucleotide polymorphism in the gene CYP46A1 (IVS2 -150 T>C; rs754203) has recently been associated with primary open ...
Georg, Mossböck, Martin, Weger, Christoph, Faschinger, Otto, Schmut, Wilfried, Renner, Andreas, Wedrich, Christina, Zimmermann, Yosuf, El-Shabrawi   +7 more
openaire   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

ePoster

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

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Metabolism of oral turinabol by the human brain cholesterol 24-hydroxylase CYP46A1

The Journal of Steroid Biochemistry and Molecular Biology, 2021
The human microsomal cytochrome P450 enzyme CYP46A1 plays a crucial role in cholesterol elimination from the brain. It performs a 24-hydroxylation of cholesterol and is of outstanding significance for memory and cognition. This study demonstrates the catalytic activity of human CYP46A1 towards an anabolic androgenic steroid, oral turinabol ...
Natalia Putkaradze, Philip Hartz, Michael C. Hutter, Josef Zapp, Mario Thevis, Rita Bernhardt   +5 more
openaire   +2 more sources

Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2016
Dysfunctions in brain cholesterol homeostasis have been extensively related to brain disorders. The major elimination pathway of brain cholesterol is its hydroxylation into 24 (S)-hydroxycholesterol by the cholesterol 24-hydroxylase (CYP46A1). Interestingly, there seems to be an association between CYP46A1 and high-order brain functions, in a sense ...
Miguel, Moutinho, Maria João, Nunes, Elsa, Rodrigues   +2 more
openaire   +2 more sources

Cholesterol-24S-hydroxylase (CYP46A1) Is Specifically Expressed in Neurons of the Neural Retina

Current Eye Research, 2007
Increasing biological findings argue for the importance of cholesterol-24S-hydroxylase (CYP46A1) in cholesterol homeostasis in cerebral structures. Based on the similarity between the brain and the neural retina, the aim of the current study was to evaluate the expression of CYP46A1 in the mammalian retina.
Brétillon, Lionel, Diczfalusy, Ulf, Bjorkhem, Ingemar, Maire, Marie-Annick, Martine, Lucy, Joffre, Corinne, Acar, Niyazi, Bron, Alain, M., Creuzot Garcher, Catherine, Creuzot-Garcher, Catherine   +9 more
openaire   +4 more sources

24S-hydroxycholesterol and cholesterol-24S-hydroxylase (CYP46A1) in the retina: from cholesterol homeostasis to pathophysiology of glaucoma

Chemistry and Physics of Lipids, 2011
Free cholesterol is the predominant form of cholesterol in the neural retina. The vertebrate neural retina exhibits its own capacity to synthesize cholesterol and meets its demand also by taking it from the circulation. Defects in cholesterol synthesis and trafficking in the neural retina has detrimental consequences on its structure and function ...
Fourgeux, Cynthia, Bron, Alain, Acar, Niyazi, Creuzot-Garcher, Catherine, Brétillon, Lionel   +4 more
openaire   +3 more sources

In vivo consequences of cholesterol-24S-hydroxylase (CYP46A1) inhibition by voriconazole on cholesterol homeostasis and function in the rat retina

Biochemical and Biophysical Research Communications, 2014
Cholesterol 24S-hydroxylase (CYP46A1) converts cholesterol into 24S-hydroxycholesterol in neurons and participates in cholesterol homeostasis in the central nervous system, including the retina. We aimed to evaluate the consequences of CYP46A1 inhibition by voriconazole on cholesterol homeostasis and function in the retina.
Fourgeux, Cynthia, Martine, Lucy, Acar, Niyazi, Bron, Alain, Creuzot-Garcher, Catherine, Brétillon, Lionel   +5 more
openaire   +3 more sources