Results 11 to 20 of about 175 (152)

Polymorphism in the cholesterol 24S-hydroxylase gene is associated with Alzheimer's disease [PDF]

Molecular Psychiatry, 2002
Cholesterol and 24S-hydroxycholesterol are involved in the pathogenesis of Alzheimer's disease (AD). Increased serum cholesterol concentrations have been detected in patients with AD. 24S-Hydroxycholesterol is the primary cholesterol elimination product of the brain and possesses neurotoxic properties in vitro.
Heike, Kölsch, D, Lütjohann, M, Ludwig, A, Schulte, U, Ptok, F, Jessen, K, von Bergmann, M L, Rao, W, Maier, R, Heun   +9 more
openaire   +2 more sources

Cholesterol 24-hydroxylase at the choroid plexus contributes to brain immune homeostasis

Cell Reports Medicine, 2023
The choroid plexus (CP) plays a key role in remotely controlling brain function in health, aging, and disease. Here, we report that CP epithelial cells express the brain-specific cholesterol 24-hydroxylase (CYP46A1) and that its levels are decreased under different mouse and human brain conditions, including amyloidosis, aging, and SARS-CoV-2 infection.
Tsitsou-Kampeli, Afroditi, Suzzi, Stefano, Kenigsbuch, Mor, Satomi, Akisawa, Strobelt, Romano, Singer, Oded, Feldmesser, Ester, Purnapatre, Maitreyee, Colaiuta, Sarah Phoebeluc, David, Eyal, Cahalon, Liora, Hahn, Oliver, Wyss-Coray, Tony, Shaul, Yosef, Amit, Ido, Schwartz, Michal   +15 more
openaire   +2 more sources

The CH24H metabolite, 24HC, blocks viral entry by disrupting intracellular cholesterol homeostasis

Redox Biology, 2023
Cholesterol-24-hydroxylase (CH24H or Cyp46a1) is a reticulum-associated membrane protein that plays an irreplaceable role in cholesterol metabolism in the brain and has been well-studied in several neuro-associated diseases in recent years.
Yueming Yuan, An Fang, Zongmei Wang, Zhihui Wang, Baokun Sui, Yunkai Zhu, Yuan Zhang, Caiqian Wang, Rong Zhang, Ming Zhou, Huanchun Chen, Zhen F. Fu, Ling Zhao   +12 more
doaj   +1 more source

Highly automated nano-LC/MS-based approach for thousand cell-scale quantification of side chain-hydroxylated oxysterols[S]

Journal of Lipid Research, 2014
Iso-octyl chain-hydroxylated oxysterols were determined in attomoles per 10,000 cells concentrations in 10,000–80,000 cultured pancreatic adenocarcinoma cells, using a sensitive, highly automated nano-LC-ESI-MS-based method.
Hanne Roberg-Larsen, Kaja Lund, Tore Vehus, Nina Solberg, Caroline Vesterdal, Dorna Misaghian, Petter Angell Olsen, Stefan Krauss, Steven Ray Wilson, Elsa Lundanes   +9 more
doaj   +1 more source

Neuronal expression and subcellular localization of cholesterol 24‐hydroxylase in the mouse brain [PDF]

Journal of Comparative Neurology, 2008
AbstractCholesterol 24‐hydroxylase is a cytochrome P450 (CYP46A1) that is selectively expressed in the brain and is responsible for the majority of cholesterol turnover in the central nervous system. Mice deficient in 24‐hydroxylase exhibit impaired learning and defective hippocampal long‐term potentiation, suggesting that the metabolism of cholesterol
Denise M O, Ramirez, Stefan, Andersson, David W, Russell   +2 more
openaire   +2 more sources

24-Hydroxycholesterol is a substrate for hepatic cholesterol 7α-hydroxylase (CYP7A)

Journal of Lipid Research, 2000
(24S)-Hydroxycholesterol is formed from cholesterol in the brain and is important for cholesterol homeostasis in this organ. Elimination of (24S)-hydroxycholesterol has been suggested to occur in the liver but little is known about the metabolism of this
Maria Norlin, Anders Toll, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +1 more source

Increased Plasma Level of 24S-Hydroxycholesterol and Polymorphism of CYP46A1 SNP (rs754203) Are Associated With Mild Cognitive Impairment in Patients With Type 2 Diabetes

Frontiers in Aging Neuroscience, 2021
BackgroundAbnormal cholesterol metabolism is common in type 2 diabetes mellitus (T2DM) and causes dementia. Cholesterol 24S-hydroxylase (CYP46A1) converts cholesterol into 24S-hydroxycholesterol (24-OHC) and maintains cholesterol homeostasis in the brain.
Jijing Shi, Jijing Shi, Jianhong Jia, Sai Tian, Sai Tian, Haoqiang Zhang, Haoqiang Zhang, Ke An, Ke An, Wenwen Zhu, Wenwen Zhu, Wuyou Cao, Wuyou Cao, Yang Yuan, Shaohua Wang   +14 more
doaj   +1 more source

Expression and purification of human cholesterol 7 alpha-hydroxylase in Escherichia coli.

Journal of Lipid Research, 1994
Cholesterol 7 alpha-hydroxylase (P450c7) is the first and rate-limiting enzyme in bile acid biosynthesis and is the product of a cytochrome P450 gene, CYP7.
W G Karam, J Y Chiang
doaj   +1 more source

Knockout of the Cholesterol 24-Hydroxylase Gene in Mice Reveals a Brain-specific Mechanism of Cholesterol Turnover [PDF]

Journal of Biological Chemistry, 2003
Most cholesterol turnover takes place in the liver and involves the conversion of cholesterol into soluble and readily excreted bile acids. The synthesis of bile acids is limited to the liver, but several enzymes in the bile acid biosynthetic pathway are expressed in extra-hepatic tissues and there also may contribute to cholesterol turnover.
Erik G, Lund, Chonglun, Xie, Tiina, Kotti, Stephen D, Turley, John M, Dietschy, David W, Russell   +5 more
openaire   +2 more sources

Repression of cholesterol 7 alpha-hydroxylase transcription by bile acids is mediated through protein kinase C in primary cultures of rat hepatocytes.

Journal of Lipid Research, 1995
Inhibitors of protein kinases were screened for the ability to prevent the repression of cholesterol 7 alpha-hydroxylase mRNA by taurocholate in primary cultures of adult rat hepatocytes.
R T Stravitz, Z R Vlahcevic, E C Gurley, P B Hylemon   +3 more
doaj   +1 more source