Results 21 to 30 of about 175 (152)

Oxysterols in the brain of the cholesterol 24-hydroxylase knockout mouse

Biochemical and Biophysical Research Communications, 2014
Oxysterols are oxidised forms of cholesterol or its precursors. In this study we utilised the cholesterol 24-hydroxylase knockout mouse (Cyp46a1-/-) to study the sterol and oxysterol content of brain. Despite a great reduction in the abundance of 24S-hydroxycholesterol, the dominant metabolite of cholesterol in wild type brain, no other cholesterol ...
Meljon, Anna, Wang, Yuqin, Griffiths, William J   +2 more
openaire   +4 more sources

Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration

Journal of Lipid Research, 2003
Although the pool of cholesterol in the adult central nervous system (CNS) is large and of constant size, little is known of the process(es) involved in regulation of sterol turnover in this pool. In 7-week-old mice, net excretion of cholesterol from the
Chonglun Xie, Erik G. Lund, Stephen D. Turley, David W. Russell, John M. Dietschy   +4 more
doaj   +1 more source

Transcriptional regulation of cholesterol 24-hydroxylase by histone deacetylase inhibitors

Biochemical and Biophysical Research Communications, 2009
The mechanistic basis for the tissue specific expression of cholesterol elimination pathways is poorly understood. To gain additional insight into this phenomenon we considered it of interest to investigate if epigenetic mechanisms are involved in the regulation of the brain-specific enzyme cholesterol 24-hydroxylase (CYP46A1), a key regulator of brain
Shafaati, Marjan, O'Driscoll, Riona, Bjorkhem, Ingemar, Meaney, Steve   +3 more
openaire   +5 more sources

Upregulation of cholesterol 24-hydroxylase following hypoxia–ischemia in neonatal mouse brain [PDF]

Pediatric Research, 2018
BackgroundMaintenance of cholesterol homeostasis is crucial for brain development. Brain cholesterol relies on de novo synthesis and is cleared primarily by conversion to 24S-hydroxycholesterol (24S-HC) with brain-specific cholesterol 24-hydroxylase (CYP46A1).
Lu, Fuxin, Zhu, Jun, Guo, Selena, Wong, Brandon J, Chehab, Farid F, Ferriero, Donna M, Jiang, Xiangning   +6 more
openaire   +4 more sources

Effect of Amyloid Beta on Cholesterol Metabolism-Correlated microRNAs in Primary Cultured Astrocytes of C57BL/6J Mice: A Focus on CYP46A1 and APOE Genes [PDF]

Cell Journal
Objective: The accumulation of amyloid plaques and disturbance of cholesterol homeostasis are implicated in thepathophysiology of Alzheimer’s disease. Apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) are keyproteins involved in the efflux
Bahar Jaberian Asl, Zahra Nazeri, Seyadeh Pardis Pezeshki, Alireza Kheirollah, Shirin Azizidoost, Maryam Adelipour, Maryam Cheraghzadeh   +6 more
doaj   +1 more source

Population pharmacokinetics, enzyme occupancy, and 24S‐hydroxycholesterol modeling of soticlestat, a novel cholesterol 24‐hydroxylase inhibitor, in healthy adults

Clinical and Translational Science, 2023
Soticlestat is a first‐in‐class, selective inhibitor of cholesterol 24‐hydroxylase (CH24H), which catabolizes cholesterol to 24S‐hydroxycholesterol (24HC) in the brain, in phase III development for Dravet syndrome and Lennox–Gastaut syndrome treatment ...
Wei Yin, Axel Facius, Thomas Wagner, Max Tsai, Mahnaz Asgharnejad, Gëzim Lahu, Majid Vakilynejad   +6 more
doaj   +1 more source

Ileal bile acid transport regulates bile acid pool, synthesis, and plasma cholesterol levels differently in cholesterol-fed rats and rabbits

Journal of Lipid Research, 2000
We investigated the effect of ileal bile acid transport on the regulation of classic and alternative bile acid synthesis in cholesterol-fed rats and rabbits.
Guorong Xu, Benjamin L. Shneider, Sarah Shefer, Lien B. Nguyen, Ashok K. Batta, G. Stephen Tint, Marco Arrese, Sundararajah Thevananther, Lin Ma, Siegfried Stengelin, Werner Kramer, David Greenblatt, Mark Pcolinsky, Gerald Salen   +13 more
doaj   +1 more source

Inhibition of Marek’s Disease Virus Replication and Spread by 25-hydroxycholesterol and 27-hydroxycholesterol In Vitro

Viruses, 2023
Marek’s disease virus (MDV) causes a deadly lymphoproliferative disease in chickens, resulting in huge economic losses in the poultry industry. It has been suggested that MDV suppresses the induction of type I interferons and thus escapes immune control.
Nitin Kamble, Vishwanatha R. A. P. Reddy, Ben Jackson, Faisal R. Anjum, Chidiebere C. Ubachukwu, Ajit Patil, Shahriar Behboudi   +6 more
doaj   +1 more source

Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells

Journal of Lipid Research, 1996
A stable HepG2 cell line harboring a human cholesterol 7 alpha-hydroxylase (CYP7A) minigene/luciferase reporter gene construct was selected for studying transcriptional regulation of CYP7A gene promoter.
D P Wang, D Stroup, M Marrapodi, M Crestani, G Galli, J Y Chiang   +5 more
doaj   +1 more source

Cholesterol 25-hydroxylation activity of CYP3A

Journal of Lipid Research, 2011
To date, many studies have been conducted using 25-hydroxycholesterol, which is a potent regulator of lipid metabolism. However, the origins of this oxysterol have not been entirely elucidated. Cholesterol 25-hydroxylase is one of the enzymes responsible
Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki   +8 more
doaj   +1 more source