Results 251 to 260 of about 111,376 (287)
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Cholesterol esterase accelerates intestinal cholesterol absorption
Biochimica et Biophysica Acta (BBA) - General Subjects, 2002Mechanisms of acceleration of cholesterol absorption by cholesterol esterase were investigated in various experimental conditions. Lymphatic recovery of cholesterol intubated as a micellar solution containing phosphatidylcholine (PC) into the duodenum was enhanced by the co-administration of cholesterol esterase in rats drained of bile and pancreatic ...
Ikuo, Ikeda +11 more
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Current Opinion in Gastroenterology, 2002
Cholesterol absorption is a key regulatory point in human lipid metabolism because it determines the amount of endogenous biliary as well as dietary cholesterol that is retained, thereby influencing whole body cholesterol balance. Plant sterols (phytosterols) and the drug ezetimibe reduce cholesterol absorption and low-density lipoprotein cholesterol ...
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Cholesterol absorption is a key regulatory point in human lipid metabolism because it determines the amount of endogenous biliary as well as dietary cholesterol that is retained, thereby influencing whole body cholesterol balance. Plant sterols (phytosterols) and the drug ezetimibe reduce cholesterol absorption and low-density lipoprotein cholesterol ...
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Hypolipidemic therapy and cholesterol absorption
Current Atherosclerosis Reports, 2004The advent of safe and effective hypolipidemic therapy has revolutionized the ability of the clinician to optimize abnormalities in the lipid profile. The advent of statin therapy has provided a potent option to decrease low-density lipoprotein and frequently allows achievement of National Cholesterol Education Program target lipid levels with ...
Amit, Manhas, John A, Farmer
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Steroidal Glycoside Cholesterol Absorption Inhibitors
Journal of Medicinal Chemistry, 1997We have explored the use of steroidal glycosides as cholesterol absorption inhibitors which act through an unknown mechanism. The lead for this program was tigogenin cellobioside (1, tiqueside) which is a weak inhibitor (ED50 = 60 mg/kg) as measured in an acute hamster cholesterol absorption assay.
M P, DeNinno +12 more
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Cholesterol Absorption Blockade with Ezetimibe
Current Drug Target -Cardiovascular & Hematological Disorders, 2005The reduction of circulating atherogenic lipoproteins through lifestyle modification and pharmacologic intervention is an important therapeutic goal in patients at risk for acute cardiovascular events. A large number of clinical trials have demonstrated that the reduction of low-density lipoprotein cholesterol (LDL-C) is associated with significant ...
Peter P, Toth, Michael H, Davidson
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Cholesterol Absorption and Metabolism
2009Inhibitors of cholesterol absorption have been sought for decades as a means to treat and prevent cardiovascular diseases (CVDs) associated with hypercholesterolemia. Ezetimibe is the one clear success story in this regard, and other compounds with similar efficacy continue to be sought.
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Dietary cholesterol absorption
The Lancet, 2001In the early 1970s, Bhattacharyya and Connor studied two sisters who complained of arthralgias, and had tendon xanthomas and haemolytic anaemia. The doctors recognised the symptoms as those of autosomal dominant familial hypercholesterolaemia.
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Bioactives for cholesterol lowering: targeting of cholesterol absorption pathways
Expert Opinion on Drug Discovery, 2007The relationship between serum cholesterol and coronary heart disease is well established. Inhibitors of endogenous cholesterol synthesis (statins) have been shown to reduce cardiovascular events. Similarly, strategies directed towards the gastrointestinal tract may also be effective, as cholesterol absorption via the intestinal lumen is known to ...
Wayne R, Leifert, Mahinda Y, Abeywardena
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Regulation of Intestinal Cholesterol Absorption
Annual Review of Physiology, 2007The identification of defective structures in the ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 in patients with sitosterolemia suggests that these two proteins are an apical sterol export pump promoting active efflux of cholesterol and plant sterols from enterocytes back into the intestinal lumen for excretion.
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Cholesterol metabolism. II. Quantitative measurement of cholesterol absorption
Journal of Applied Physiology, 1965A simple physiological method for quantitative study of cholesterol absorption is presented. The method uses the fecal bile acid tracer of dietary cholesterol-4-C14 as an index of cholesterol that has been absorbed, metabolized, and re-excreted. Since the fecal bile acid-to-sterol excretion ratio for rats on any specific diet is constant and can be ...
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