Results 241 to 250 of about 1,294,493 (295)

Regulation of cholesterol absorption by phytosterols

Current Atherosclerosis Reports, 2006
Phytosterols are chemical homologs of cholesterol that are found in most plant foods and are particularly abundant in vegetable oils and whole grains. They interfere with the micellar solubilization of cholesterol in the intestine and reduce the efficiency of cholesterol absorption.
Richard E, Ostlund, Xiaobo, Lin
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Cholesterol Absorption and Metabolism

2009
Inhibitors of cholesterol absorption have been sought for decades as a means to treat and prevent cardiovascular diseases (CVDs) associated with hypercholesterolemia. Ezetimibe is the one clear success story in this regard, and other compounds with similar efficacy continue to be sought.
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Hypolipidemic therapy and cholesterol absorption

Current Atherosclerosis Reports, 2004
The advent of safe and effective hypolipidemic therapy has revolutionized the ability of the clinician to optimize abnormalities in the lipid profile. The advent of statin therapy has provided a potent option to decrease low-density lipoprotein and frequently allows achievement of National Cholesterol Education Program target lipid levels with ...
Amit, Manhas, John A, Farmer
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Absorption of dietary cholesterol in man

Metabolism, 1973
Abstract Cholesterol absorption was studied by balance methods in 10 hyperlipemic subjects. The cholesterol (401–1214 mg/day) and β-sitosterol (171–454 mg/day) were integral parts of the diets. The absorption was 37% ± 5% and the amounts of cholesterol absorbed were 149–508 mg/day.
B J, Kudchodkar, H S, Sodhi, L, Horlick
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Cholesterol Absorption Blockade with Ezetimibe

Current Drug Target -Cardiovascular & Hematological Disorders, 2005
The reduction of circulating atherogenic lipoproteins through lifestyle modification and pharmacologic intervention is an important therapeutic goal in patients at risk for acute cardiovascular events. A large number of clinical trials have demonstrated that the reduction of low-density lipoprotein cholesterol (LDL-C) is associated with significant ...
Peter P, Toth, Michael H, Davidson
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Regulation of Intestinal Cholesterol Absorption

Annual Review of Physiology, 2007
The identification of defective structures in the ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 in patients with sitosterolemia suggests that these two proteins are an apical sterol export pump promoting active efflux of cholesterol and plant sterols from enterocytes back into the intestinal lumen for excretion.
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Bioactives for cholesterol lowering: targeting of cholesterol absorption pathways

Expert Opinion on Drug Discovery, 2007
The relationship between serum cholesterol and coronary heart disease is well established. Inhibitors of endogenous cholesterol synthesis (statins) have been shown to reduce cardiovascular events. Similarly, strategies directed towards the gastrointestinal tract may also be effective, as cholesterol absorption via the intestinal lumen is known to ...
Wayne R, Leifert, Mahinda Y, Abeywardena
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Effect of Lovastatin on Cholesterol Absorption in Cholesterol‐Fed Rabbits

Pharmacology & Toxicology, 1993
Abstract: The aim of the present study was to investigate the effect of the hydroxymethylglutaryl (HMG)‐CoA reductase inhibitor lovastatin on some aspects of cholesterol metabolism in cholesterol‐fed rabbits. The plasma cholesterol concentration was markedly lower in lovastatin‐treated rabbits (6 mg/rabbit/day) compared to controls after 36 days of ...
L B, Nielsen, S, Stender, K, Kjeldsen
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Regulation of Cholesterol Absorption in Humans

1985
Cholesterol is undoubtedly the most abundant sterol present in the mammalian species; it has been estimated that cholesterol represents 0.2% of body weight, that in an average man of 70 Kg means 145g, 8 of which contained in the blood[l]. Cholesterol is virtually insoluble in water, however, having a hydroxyl group is soluble at the surface and can ...
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Cholesterol metabolism. II. Quantitative measurement of cholesterol absorption

Journal of Applied Physiology, 1965
A simple physiological method for quantitative study of cholesterol absorption is presented. The method uses the fecal bile acid tracer of dietary cholesterol-4-C14 as an index of cholesterol that has been absorbed, metabolized, and re-excreted. Since the fecal bile acid-to-sterol excretion ratio for rats on any specific diet is constant and can be ...
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