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Cholesterol Absorption Blockade with Ezetimibe
Current Drug Target -Cardiovascular & Hematological Disorders, 2005The reduction of circulating atherogenic lipoproteins through lifestyle modification and pharmacologic intervention is an important therapeutic goal in patients at risk for acute cardiovascular events. A large number of clinical trials have demonstrated that the reduction of low-density lipoprotein cholesterol (LDL-C) is associated with significant ...
Peter P, Toth, Michael H, Davidson
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Regulation of Intestinal Cholesterol Absorption
Annual Review of Physiology, 2007The identification of defective structures in the ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 in patients with sitosterolemia suggests that these two proteins are an apical sterol export pump promoting active efflux of cholesterol and plant sterols from enterocytes back into the intestinal lumen for excretion.
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Bioactives for cholesterol lowering: targeting of cholesterol absorption pathways
Expert Opinion on Drug Discovery, 2007The relationship between serum cholesterol and coronary heart disease is well established. Inhibitors of endogenous cholesterol synthesis (statins) have been shown to reduce cardiovascular events. Similarly, strategies directed towards the gastrointestinal tract may also be effective, as cholesterol absorption via the intestinal lumen is known to ...
Wayne R, Leifert, Mahinda Y, Abeywardena
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Effect of Lovastatin on Cholesterol Absorption in Cholesterol‐Fed Rabbits
Pharmacology & Toxicology, 1993Abstract: The aim of the present study was to investigate the effect of the hydroxymethylglutaryl (HMG)‐CoA reductase inhibitor lovastatin on some aspects of cholesterol metabolism in cholesterol‐fed rabbits. The plasma cholesterol concentration was markedly lower in lovastatin‐treated rabbits (6 mg/rabbit/day) compared to controls after 36 days of ...
L B, Nielsen, S, Stender, K, Kjeldsen
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Cholesterol metabolism. II. Quantitative measurement of cholesterol absorption
Journal of Applied Physiology, 1965A simple physiological method for quantitative study of cholesterol absorption is presented. The method uses the fecal bile acid tracer of dietary cholesterol-4-C14 as an index of cholesterol that has been absorbed, metabolized, and re-excreted. Since the fecal bile acid-to-sterol excretion ratio for rats on any specific diet is constant and can be ...
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Intestinal cholesterol absorption
Current Opinion in Lipidology, 2018Maaike, Kockx, Leonard, Kritharides
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Regulation of Cholesterol Absorption in Humans
1985Cholesterol is undoubtedly the most abundant sterol present in the mammalian species; it has been estimated that cholesterol represents 0.2% of body weight, that in an average man of 70 Kg means 145g, 8 of which contained in the blood[l]. Cholesterol is virtually insoluble in water, however, having a hydroxyl group is soluble at the surface and can ...
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THE MECHANISM OF CHOLESTEROL ABSORPTION
Annals of the New York Academy of Sciences, 1959L, SWELL +4 more
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