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Steroidal Triterpenes of Cholesterol Synthesis [PDF]
Molecules, 2013 Cholesterol synthesis is a ubiquitous and housekeeping metabolic pathway that leads to cholesterol, an essential structural component of mammalian cell membranes, required for proper membrane permeability and fluidity. The last part of the pathway involves steroidal triterpenes with cholestane ring structures.
Damjana Rozman, Rozman Damjana
exaly +5 more sources
Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice
Journal of Lipid Research, 2016 Statins are competitive inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis. Statins reduce plasma cholesterol levels, but whether this is actually caused by inhibition of de novo cholesterol synthesis has not been clearly ...
Marleen Schonewille +9 more
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Intracellular Cholesterol Synthesis and Transport
Frontiers in Cell and Developmental Biology, 2022 Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export.
Xiaochun Tang +2 more
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Journal of Lipid Research, 2009 This study evaluates changes in cholesterol balance in hypercholesterolemic subjects following treatment with an inhibitor of cholesterol absorption or cholesterol synthesis or coadministration of both agents. This was a randomized, double blind, placebo-
Thomas Sudhop +8 more
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The interaction of cholesterol absorption and cholesterol synthesis in man
Journal of Lipid Research, 1969 The total miscible pool of cholesterol in the body is determined largely by the interaction of cholesterol absorption and synthesis. In the present study we have examined the net effects of this interplay in one normal and five hypercholesteremic ...
Scott M. Grundy +2 more
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Synthesis of a Smoothened Cholesterol: 18,19-Di-nor-cholesterol [PDF]
Journal of Organic Chemistry, 2014 Herein, we report the first synthesis of a demethylated form of cholesterol (18,19-di-nor-cholesterol), in which the C18 and C19 methyl groups of the β-face were eliminated. Recent molecular simulations modeling 18,19-di-nor-cholesterol have suggested that cholesterol's opposing rough β-face and smooth α-face play necessary roles in cholesterol's ...
Laurel Mcgrane +2 more
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Biomedicines, 2023 Inflammation is associated with changes in plasma lipids, lipoproteins, and cholesterol efflux capacity (CEC). It is unknown if the changes in lipids and lipoproteins during inflammation are related to changes in cholesterol absorption, synthesis, and ...
Sultan Mashnafi +6 more
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Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption
Journal of Lipid Research, 2002 Heredity of cholesterol absorption and synthesis was studied in siblings of hypercholesterolemic probands with low and high serum cholestanol to cholesterol ratio (assumed to indicate low and high absorption of cholesterol, respectively).
Helena Gylling, Tatu A. Miettinen
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Evidence for a common biliary cholesterol and VLDL cholesterol precursor pool in rat liver.
Journal of Lipid Research, 1992 Hepatic free cholesterol levels are influenced by cholesterol synthesis and ester formation, which, in turn, might regulate cholesterol secretion into bile and plasma.
BG Stone, CD Evans
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Animals, 2023 This study aimed to investigate the effect of HMGCR inhibitors on egg yolk cholesterol content and its biological mechanisms. Four groups of 180-day-old laying hens (n = 8 cages/group, 6 laying hens/cage) were fed a corn/soybean-based diet (control) and ...
Huanbin Wang +4 more
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