Results 21 to 30 of about 262,864 (261)

Evaluation of the use of serum lathosterol concentration to assess whole-body cholesterol synthesis in rabbits.

Journal of Lipid Research, 1992
Serum lathosterol concentration in rabbits was assessed as a possible indicator of whole-body cholesterol synthesis. In random-bred New Zealand White (NZW) rabbits fed a control diet or a diet containing either cholesterol, simvastatin, or cholestyramine,
GW Meijer, JG Van der Palen, H De Vries, HJ Kempen, HA Van der Voort, LF Van Zutphen, AC Beynen   +6 more
doaj   +1 more source

Cholesterol metabolism in hypothyroidism and hyperthyroidism in man.

Journal of Lipid Research, 1981
Studies were carried out on cholesterol metabolism in 11 nonobese patients and 16 obese patients with hypothyroidism and 13 with hyperthyroidism. The patients underwent several investigations under metabolic ward conditions.
J J Abrams, S M Grundy
doaj   +1 more source

Functional Peroxisomes Are Essential for Efficient Cholesterol Sensing and Synthesis

Frontiers in Cell and Developmental Biology, 2020
Cholesterol biosynthesis is a multi-step process involving several subcellular compartments, including peroxisomes. Cells adjust their sterol content by both transcriptional and post-transcriptional feedback regulation, for which sterol regulatory ...
Khanichi N. Charles, Janis E. Shackelford, Phyllis L. Faust, Steven J. Fliesler, Steven J. Fliesler, Herbert Stangl, Werner J. Kovacs   +6 more
doaj   +1 more source

Markers of cholesterol synthesis to cholesterol absorption across the spectrum of non‐dialysis CKD: An observational study

Pharmacology Research & Perspectives, 2021
In dialysis patients, cholesterol‐lowering therapy with statins is less effective than in other high‐risk patients. This may be explained by a shift from cholesterol synthesis toward cholesterol absorption. In line, markers of cholesterol absorption—such
Insa E. Emrich, Gunnar H. Heine, P. Christian Schulze, Kyrill S. Rogacev, Danilo Fliser, Stefan Wagenpfeil, Michael Böhm, Dieter Lütjohann, Oliver Weingärtner   +8 more
doaj   +1 more source

Diurnal and dietary-induced changes in cholesterol synthesis correlate with levels of mRNA for HMG-CoA reductase

Journal of Lipid Research, 2000
We determined the extent to which diurnal variation in cholesterol synthesis in liver is controlled by steady-state mRNA levels for the rate-limiting enzyme in the pathway, hydroxymethylglutaryl (HMG)-CoA reductase.
Helga Jurevics, Janell Hostettler, Cheri Barrett, Pierre Morell, Arrel D. Toews   +4 more
doaj   +1 more source

Cholesterol synthesis in the perfused liver of pregnant hamsters

Journal of Lipid Research, 1987
Pregnancy is a risk factor for the development of cholesterol gallstones. In pregnant women, biliary cholesterol saturation and secretion are increased.
J Reichen, G Karlaganis, F Kern, Jr
doaj   +1 more source

Effect of evolocumab on cholesterol synthesis and absorption[S]

Journal of Lipid Research, 2016
The effects of cholesterol-lowering drugs, including those that reduce cholesterol synthesis (statins) and those that reduce cholesterol absorption (ezetimibe), on cholesterol absorption and synthesis are well understood. Proprotein convertase subtilisin/
Matthew Peach, Ren Xu, Dan Fitzpatrick, Lisa Hamilton, Ransi Somaratne, Robert Scott, Scott M. Wasserman, C. Stephen Djedjos   +7 more
doaj   +1 more source

Effects of dietary cholesterol on the regulation of total body cholesterol in man

Journal of Lipid Research, 1971
Studies on the interaction of cholesterol absorption, synthesis, and excretion were carried out in eight patients using sterol balance techniques. Absorption of dietary cholesterol was found to increase with intake; up to 1 g of cholesterol was absorbed ...
EDER QUINTÃO, SCOTT M. GRUNDY, E.H. AHRENS, JR.   +2 more
doaj   +1 more source

Origin of biliary cholesterol and lecithin in the rat: contribution of new synthesis and preformed hepatic stores.

Journal of Lipid Research, 1982
The contribution of de novo synthesis to the secretion of cholesterol and lecithin in bile was assessed in isolated rat livers, perfused with a lipid-free medium.
S J Robins, H Brunengraber
doaj   +1 more source

Sterol balance in the Smith-Lemli-Opitz syndrome: reduction in whole body cholesterol synthesis and normal bile acid production

Journal of Lipid Research, 2000
The Smith-Lemli-Opitz syndrome (SLOS) is a multiple malformation/mental retardation syndrome caused by a deficiency of the enzyme 7-dehydrocholesterol Δ7-reductase.
Robert D. Steiner, Leesa M. Linck, Donna P. Flavell, Don S. Lin, William E. Connor   +4 more
doaj   +1 more source