Results 31 to 40 of about 274,133 (264)

MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE

Frontiers in Cell and Developmental Biology, 2021
Oncogene c-Myc (referred in this report as MYC) promotes tumorigenesis in multiple human cancers. MYC regulates numerous cellular programs involved in cell growth and cell metabolism.
Fan Yang, Junjie Kou, Zizhao Liu, Wei Li, Wenjing Du   +4 more
doaj   +1 more source

Serum lathosterol levels in human subjects reflect changes in whole body cholesterol synthesis induced by lovastatin but not dietary cholesterol.

Journal of Lipid Research, 1995
We measured serum lathosterol levels and whole body cholesterol synthesis by sterol balance in 12 human subjects on a metabolic ward in four randomly allocated, 6-7 week periods: 1) lovastatin (40 mg b.i.d.) + low cholesterol diet (mean 246 mg/day); 2 ...
W C Duane
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Sterol balance in the Smith-Lemli-Opitz syndrome: reduction in whole body cholesterol synthesis and normal bile acid production

Journal of Lipid Research, 2000
The Smith-Lemli-Opitz syndrome (SLOS) is a multiple malformation/mental retardation syndrome caused by a deficiency of the enzyme 7-dehydrocholesterol Δ7-reductase.
Robert D. Steiner, Leesa M. Linck, Donna P. Flavell, Don S. Lin, William E. Connor   +4 more
doaj   +1 more source

Generation and validation of a conditional knockout mouse model for the study of the Smith-Lemli-Opitz syndrome

Journal of Lipid Research, 2021
Smith-Lemli-Opitz Syndrome (SLOS) is a developmental disorder (OMIM #270400) caused by autosomal recessive mutations in the Dhcr7 gene, which encodes the enzyme 3β-hydroxysterol-Δ7 reductase.
Babunageswararao Kanuri, Vincent Fong, Sithara Raju Ponny, Keri A. Tallman, Sriganesh Ramachandra Rao, Ned Porter, Steven J. Fliesler, Shailendra B. Patel   +7 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

A mitochondrial inhibitor of cholesterol synthesis.

Agricultural and Biological Chemistry, 1975
An inhibitor of cholesterol synthesis (ICS) was extracted from the mitochondria of starved rats’ liver, and purified by dialysis, tryptic digestion, precipitation at pH3.0 and Sephadex column chromatography. This preparation was inhibitory to cholesterol synthesis and produced one protein band in acrylamide disc electrophoresis.The acid precipitate ...
MIGICOVSKY, B. B., MADHOSINGH, C.
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Cholesterol Synthesis, Cholesterol Absorption, and Mortality in Hemodialysis Patients [PDF]

Clinical Journal of the American Society of Nephrology, 2012
Summary Background and objectives Recent clinical trials on cholesterol-lowering in patients with CKD yielded conflicting results, which might have resulted from different treatment strategies. Serum cholesterol levels are determined by endogenous synthesis and intestinal absorption, which are differentially ...
Kyrill S, Rogacev, Tobias, Pinsdorf, Oliver, Weingärtner, Markus K, Gerhart, Elena, Welzel, Kai, van Bentum, Julius, Popp, Andreas, Menzner, Danilo, Fliser, Dieter, Lütjohann, Gunnar H, Heine   +10 more
openaire   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source