Results 31 to 40 of about 444,409 (302)

Cholesterol Synthesis and Nerve Regeneration [PDF]

Journal of Neurochemistry, 1984
Abstract: In this report, we examine the requirement of cholesterol biosynthesis and its axonal transport for goldfish optic nerve regeneration. Cholesterol, labeled by intraocular injection of [3H]mevalonolactone. exhibited a delayed appearance in the optic tectum. Squalene and other minor components were labeled but not transported.
Heacock, Anne M., Klinger, Paul D., Seguin, Edward B., Agranoff, Bernard W.   +3 more
openaire   +3 more sources

Fasting reduces plasma proprotein convertase, subtilisin/kexin type 9 and cholesterol biosynthesis in humans

Journal of Lipid Research, 2010
Proprotein convertase, subtilisin/kexin type 9 (PCSK9), a key regulator of plasma LDL-cholesterol (LDL-c) and cardiovascular risk, is produced in liver and secreted into plasma where it binds hepatic LDL receptors (LDLR), leading to their degradation ...
Jeffrey D. Browning, Jay D. Horton
doaj   +1 more source

Effects of ezetimibe on cholesterol metabolism in HIV-infected patients with protease inhibitor-associated dyslipidemia: a single-arm intervention trial [PDF]

, 2018
BACKGROUND: The effects of ezetimibe on cholesterol metabolism in HIV-infected patients receiving boosted protease inhibitors have not been thoroughly assessed.
Cofán Pujol, Montserrat, Forga, María T., Larrousse Morellón, Maria, Leyes, Pere, Martínez Chamorro, Esteban José, Pérez-Heras, Ana Maria, Ros Rahola, Emilio, Trabal, Joan   +7 more
core   +1 more source

Sterol synthesis is up-regulated in cholesterol-loaded pigeon macrophages during induction of cholesterol efflux

Journal of Lipid Research, 1999
The extent to which cholesterol synthesis is modulated in macrophage foam cells by changes in cholesterol influx and efflux was determined using thioglycollate-elicited peritoneal macrophages from normal and cholesterol-fed White Carneau (WC) and Show ...
Brian K. Nordskog, Jerry W. Reagan, Jr., Richard W. St. Clair   +2 more
doaj   +1 more source

Indomethacin decreases viscosity of gallbladder bile in patients with cholesterol gallstone disease [PDF]

, 1993
There is experimental evidence that inhibition of cyclooxygenase with nonsteroidal anti-inflammatory drugs may decrease cholesterol gall-stone formation and mitigate biliary pain in gall-stone patients.
Brandl, H., Jüngst, Dieter, Lange, V., Meyer, L., Möhrle, W., Niemeyer, A., Pozo, R., Richter, Werner O., Ritter, C.   +8 more
core   +1 more source

Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men

Journal of Lipid Research, 2004
Type 2 diabetes has been associated with high synthesis and low absorption of cholesterol independent of weight, indicating that insulin resistance may be a link between glucose and cholesterol metabolism.
Jussi Pihlajamäki, Helena Gylling, Tatu A. Miettinen, Markku Laakso   +3 more
doaj   +1 more source

A Role of the Bile Salt Receptor FXR in Atherosclerosis [PDF]

, 2010
This study reviews current insights into the role of bile salts and bile salt receptors on the progression and regression of atherosclerosis. Bile salts have emerged as important modifiers of lipid and energy metabolism.
Groen, A.K., Hageman, J., Herrema, H.J., Kuipers, F.   +3 more
core   +3 more sources

Statin-induced myopathic changes in primary human muscle cells and reversal by a prostaglandin F2 alpha analogue [PDF]

, 2020
Statin-related muscle side effects are a constant healthcare problem since patient compliance is dependent on side effects. Statins reduce plasma cholesterol levels and can prevent secondary cardiovascular diseases.
Dittmar, Gunnar, Grieben, Ulrike, Grunwald, Stefanie Anke, Haafke, Stefanie, Jedraszczak, Nicole, Kress, Wolfram, Patone, Giannino, Popp, Oliver, Saar, Kathrin, Spuler, Simone, Steinhagen-Thiessen, Elisabeth   +10 more
core   +1 more source

Evaluation of the use of serum lathosterol concentration to assess whole-body cholesterol synthesis in rabbits.

Journal of Lipid Research, 1992
Serum lathosterol concentration in rabbits was assessed as a possible indicator of whole-body cholesterol synthesis. In random-bred New Zealand White (NZW) rabbits fed a control diet or a diet containing either cholesterol, simvastatin, or cholestyramine,
GW Meijer, JG Van der Palen, H De Vries, HJ Kempen, HA Van der Voort, LF Van Zutphen, AC Beynen   +6 more
doaj   +1 more source

Functional Peroxisomes Are Essential for Efficient Cholesterol Sensing and Synthesis

Frontiers in Cell and Developmental Biology, 2020
Cholesterol biosynthesis is a multi-step process involving several subcellular compartments, including peroxisomes. Cells adjust their sterol content by both transcriptional and post-transcriptional feedback regulation, for which sterol regulatory ...
Khanichi N. Charles, Janis E. Shackelford, Phyllis L. Faust, Steven J. Fliesler, Steven J. Fliesler, Herbert Stangl, Werner J. Kovacs   +6 more
doaj   +1 more source