Results 251 to 260 of about 216,203 (306)
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Intestinal cholesterol absorption
Current Opinion in Lipidology, 1999The strong association between intestinal cholesterol absorption and total plasma cholesterol level has renewed interest in the absorptive process and stimulated the generation of new animal models. Increasingly, new studies suggest that cholesterol absorption is genetically controlled and supports a protein-mediated mechanism for cholesterol uptake ...
P A, Dawson, L L, Rudel
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Current Opinion in Gastroenterology, 2002
Cholesterol absorption is a key regulatory point in human lipid metabolism because it determines the amount of endogenous biliary as well as dietary cholesterol that is retained, thereby influencing whole body cholesterol balance. Plant sterols (phytosterols) and the drug ezetimibe reduce cholesterol absorption and low-density lipoprotein cholesterol ...
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Cholesterol absorption is a key regulatory point in human lipid metabolism because it determines the amount of endogenous biliary as well as dietary cholesterol that is retained, thereby influencing whole body cholesterol balance. Plant sterols (phytosterols) and the drug ezetimibe reduce cholesterol absorption and low-density lipoprotein cholesterol ...
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Cholesterol esterase accelerates intestinal cholesterol absorption
Biochimica et Biophysica Acta (BBA) - General Subjects, 2002Mechanisms of acceleration of cholesterol absorption by cholesterol esterase were investigated in various experimental conditions. Lymphatic recovery of cholesterol intubated as a micellar solution containing phosphatidylcholine (PC) into the duodenum was enhanced by the co-administration of cholesterol esterase in rats drained of bile and pancreatic ...
Ikuo, Ikeda +11 more
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Regulation of cholesterol absorption by phytosterols
Current Atherosclerosis Reports, 2006Phytosterols are chemical homologs of cholesterol that are found in most plant foods and are particularly abundant in vegetable oils and whole grains. They interfere with the micellar solubilization of cholesterol in the intestine and reduce the efficiency of cholesterol absorption.
Richard E, Ostlund, Xiaobo, Lin
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Hypolipidemic therapy and cholesterol absorption
Current Atherosclerosis Reports, 2004The advent of safe and effective hypolipidemic therapy has revolutionized the ability of the clinician to optimize abnormalities in the lipid profile. The advent of statin therapy has provided a potent option to decrease low-density lipoprotein and frequently allows achievement of National Cholesterol Education Program target lipid levels with ...
Amit, Manhas, John A, Farmer
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Cholesterol Absorption and Metabolism
2009Inhibitors of cholesterol absorption have been sought for decades as a means to treat and prevent cardiovascular diseases (CVDs) associated with hypercholesterolemia. Ezetimibe is the one clear success story in this regard, and other compounds with similar efficacy continue to be sought.
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Absorption of dietary cholesterol in man
Metabolism, 1973Abstract Cholesterol absorption was studied by balance methods in 10 hyperlipemic subjects. The cholesterol (401–1214 mg/day) and β-sitosterol (171–454 mg/day) were integral parts of the diets. The absorption was 37% ± 5% and the amounts of cholesterol absorbed were 149–508 mg/day.
B J, Kudchodkar, H S, Sodhi, L, Horlick
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Cholesterol Absorption Blockade with Ezetimibe
Current Drug Target -Cardiovascular & Hematological Disorders, 2005The reduction of circulating atherogenic lipoproteins through lifestyle modification and pharmacologic intervention is an important therapeutic goal in patients at risk for acute cardiovascular events. A large number of clinical trials have demonstrated that the reduction of low-density lipoprotein cholesterol (LDL-C) is associated with significant ...
Peter P, Toth, Michael H, Davidson
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Bioactives for cholesterol lowering: targeting of cholesterol absorption pathways
Expert Opinion on Drug Discovery, 2007The relationship between serum cholesterol and coronary heart disease is well established. Inhibitors of endogenous cholesterol synthesis (statins) have been shown to reduce cardiovascular events. Similarly, strategies directed towards the gastrointestinal tract may also be effective, as cholesterol absorption via the intestinal lumen is known to ...
Wayne R, Leifert, Mahinda Y, Abeywardena
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Regulation of Intestinal Cholesterol Absorption
Annual Review of Physiology, 2007The identification of defective structures in the ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 in patients with sitosterolemia suggests that these two proteins are an apical sterol export pump promoting active efflux of cholesterol and plant sterols from enterocytes back into the intestinal lumen for excretion.
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