Results 191 to 200 of about 79,855 (290)

TMEM16A channel signalling microdomains in the regulation of vascular function

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic representation of TMEM16A channel signalling microdomains. Calcium influx or calcium release from the endoplasmic/sarcoplasmic reticulum (ER/SR) activates TMEM16A channels through interactions with regulatory proteins in vascular smooth muscle cells or endothelial cells. TMEM16A channel activation drives chloride efflux,
Fênix Araujo, Swapnil K. Sonkusare
wiley   +1 more source

HDL Functionality in Metabolic Syndrome: Insights From Cholesterol Efflux Capacity and NMR Spectroscopy. [PDF]

Health Sci Rep
Anita Sherly A, Rukmini MS, Guruprasad KP, Rohatgi A, Hegde A, Sindhu H, Arun S.   +6 more
europepmc   +1 more source

Impaired angiogenesis in gestational diabetes is linked to succinate/SUCNR1 axis dysregulation in late gestation

The Journal of Physiology, EarlyView.
Abstract figure legend Gestational Diabetes Mellitus (GDM) impacts on succinate metabolism and angiogenesis in the umbilical cord endothelium. (Left Panel) Succinate levels increase in both maternal and fetal circulation at delivery, with higher concentrations observed in GDM pregnancies compared to controls during late gestation.
Sergiy Klid, Francisco Algaba‐Chueca, Elsa Maymó‐Masip, Mónica Ballesteros, Montse Inglés, Albert Guarque, Nerea Vilanova‐Ricart, Ariadna Prats, Azra Kulovic‐Sissawo, Elisa Weiss, Ursula Hiden, Joan Vendrell, Sonia Fernández‐Veledo, Ana Megía   +13 more
wiley   +1 more source

TREM2-Mediated Cholesterol Efflux in Macrophages Inhibits Anti-Tumor Immunity via Limitation of CD4⁺ T and NK Cells. [PDF]

Adv Sci (Weinh)
Wang Y, Yu W, Wang X, Zhao Q, Lei Q, Li A, Liu S, Wang T, Yang L, Zhang Y.   +9 more
europepmc   +1 more source

α‐Synuclein oligomers slow down action potential firing and enhance dopamine release by increasing Cav2.2 currents in midbrain dopaminergic neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Left: the spontaneous quantal release of dopamine (DA) occurs at very low frequency in control conditions. Right: exogenous α‐synuclein potentiates Cav2.2 currents and DA release but drastically reduces the spontaneous firing rate of substantia nigra DA neurons.
Giulia Tomagra, Anthony Battaglia, Claudio Franchino, Sara Bonzano, Federico Picollo, Giuseppe Chiantia, Antonio de Iure, Paolo Calabresi, Barbara Picconi, Emilio Carbone, Silvia De Marchis, Andrea Marcantoni, Valentina Carabelli   +12 more
wiley   +1 more source

Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux. [PDF]

Int J Oral Sci
Ni N, Wang M, Yuan Z, Zhang L, Cai J, Du Q, Li P, Gao C, Zhang H, Li Y, Yuan H.   +10 more
europepmc   +1 more source

Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux [PDF]

, 2018
Jeong, Se-Jin, Jung, In-hyuk
core   +1 more source

Functional Segregation of Pancreatic Microcirculation Reveals Sex‐Dependent Microhemodynamic Signatures

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Pancreatic exocrine microcirculation exhibits sexual dimorphism arising from steroid–genetic interactions. Laser Doppler flowmetry combined with wavelet analysis identifies a male passive coupling phenotype aligned with systemic pressure and a female active vasomotion phenotype driven by ERβ‐mediated, NO‐dependent oscillations.
Yuan Li, Yingyu Wang, Bing Wang, Qin Ouyang, Weiqi Liu, Xiang Xu, Xu Zhang, Mingming Liu, Ruijuan Xiu   +8 more
wiley   +1 more source

To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux. [PDF]

Front Med (Lausanne)
Jia C, Hong B, Jiang Y, Ma C, Liu W, Xu Y, Chen J, Xie Y, Ge G, Cao YM, Yan T, Cao Y.   +11 more
europepmc   +1 more source

Ischemic Colitis Secondary to Mesenteric Arteriovenous Malformation: A Rare Cause of Bowel Ischemia—Case Report and Literature Review

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Ischemic colitis is the most common form of intestinal ischemia, typically caused by a temporary reduction in blood flow to the colon. It is often linked to atherosclerosis, low blood pressure, or embolism. We present a case of ischemic colitis with atypical location due to an inferior mesenteric arteriovenous malformation (inferior mesenteric
Arparat Kanacharoen, Nantaporn Srivanitchapoom, Pornrujee Hirunpat, Nuttapat Tungtrongchitr   +3 more
wiley   +1 more source