Results 201 to 210 of about 80,716 (308)

Regulated Cell Death in Idiopathic Pulmonary Fibrosis

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan, Liu Yang, Man Zhao, Yanlin Zhou, Cong Xia, Huibing Liu, Yuqi Wang, Hui Lian, Bin Li, Lan Wang, Guoying Yu   +10 more
wiley   +1 more source

Antisense oligonucleotide targeting TARDBP-EGFR splicing axis inhibits progression of oral squamous cell carcinoma through ABCA1-regulated cholesterol efflux. [PDF]

Int J Oral Sci
Ni N, Wang M, Yuan Z, Zhang L, Cai J, Du Q, Li P, Gao C, Zhang H, Li Y, Yuan H.   +10 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, Volume 16, Issue 5, Page 857-869, May 2026.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

To elucidate the effect of Ruanjian Qingmai granules on arteriosclerosis obliterans from the perspective of cholesterol efflux. [PDF]

Front Med (Lausanne)
Jia C, Hong B, Jiang Y, Ma C, Liu W, Xu Y, Chen J, Xie Y, Ge G, Cao YM, Yan T, Cao Y.   +11 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, Volume 16, Issue 5, Page 837-856, May 2026.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Mediterranean Diet Modulates Gene Expression of Cholesterol Efflux Receptors in High-Risk Cardiovascular Patients. [PDF]

Mol Nutr Food Res
Hernando-Redondo J, Hernáez Á, Sanllorente A, Pintó X, Estruch R, Salas-Salvadó J, Corella D, Arós F, Martínez-González MÁ, Subirana I, Muñoz-Aguayo D, Malcampo M, Serra-Majem L, Romaguera D, Lapetra J, Ros E, Tinahones F, Lamuela-Raventós RM, Gómez-Gracia E, Fitó M, Castañer O.   +20 more
europepmc   +1 more source

Apolipoprotein A‐I (CSL112) and Cardiovascular Outcomes in Atherosclerotic Cardiovascular Disease: A Scoping Review

Clinical Cardiology, Volume 49, Issue 5, May 2026.
Apolipoprotein A‐I (ApoA‐I), the principal protein of HDL, plays a key role in reverse cholesterol transport, inflammation modulation, and plaque stabilization in atherosclerotic cardiovascular disease. Emerging ApoA‐I–based therapies, including CSL112, enhance cholesterol efflux capacity, though definitive reductions in cardiovascular events remain ...
Awais Habib, Muhammad Saood Moazzam Khan, Ahmad Aneeq, Hafiz Muhammad Talha Tahir, Amin Mehmoodi, Jahanzeb Malik, Abida Perveen   +6 more
wiley   +1 more source

Nitroxoline mitigates hepatic steatosis by enhancing cholesterol efflux and promoting bile acid synthesis through LRH-1 signaling. [PDF]

Lipids Health Dis
Liu WC, Lien CF, Huang YJ, Lien PY, Chen SJ, Lin CS, Cho RL, Chuang YP.   +7 more
europepmc   +1 more source

Intersecting Molecular Pathways in Cardiovascular Disease and Diabetes Mellitus: Emerging Roles of Inflammation and Therapeutics

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.
Central illustration: Pathophysiological mechanisms linking diabetes mellitus and cardiovascular disease. Chronic hyperglycaemia, insulin resistance, and low‐grade inflammation contribute to endothelial dysfunction, myocardial fibrosis, and cardiomyocyte apoptosis.
Lilian Anagnostopoulou, Nikolaos Ktenopoulos, Anastasios Apostolos, Christos Fragoulis, Panayotis Vlachakis, Paschalis Karakasis, Marios Sagris, Nikias Milaras, Maria Drakopoulou, Andreas Synetos, Ioannis Kyriazis, Ioannis Ioannidis, Costas Tsioufis, Konstantinos Toutouzas   +13 more
wiley   +1 more source