Results 211 to 220 of about 79,855 (290)

Acceleration of HDL-Mediated Cholesterol Efflux Alleviates Periodontitis. [PDF]

J Dent Res
Tran TT, Lee G, Huh YH, Chung KH, Lee SY, Park KH, Kim JH, Kook MS, Ryu J, Kim OS, Lim HP, Koh JT, Ryu JH.   +12 more
europepmc   +1 more source

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, Volume 183, Issue 8, Page 1640-1652, April 2026.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source

Effect of bariatric surgery on HDL-mediated cholesterol efflux capacity. [PDF]

Front Cardiovasc Med
Castañer O, Pérez-Vega KA, Álvarez S, Vázquez S, Casajoana A, Blanchart G, Gaixas S, Schröder H, Zomeño MD, Subirana I, Muñoz-Aguayo D, Fitó M, Benaiges D, Goday A, Oliveras A.   +14 more
europepmc   +1 more source

From Single‐Cell Clusters to Causality: ITCH Engagement for CKD Uncovered by Integrative Analysis of MR and MAGMA

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
This graphical abstract illustrates an integrative analysis of single‐cell RNA‐seq data in CKD. DEGs were subsequently identified as candidate genes via Mendelian randomization analysis and combined with MAGMA analysis, ITCH was identified as a key gene.
Xia Zhang, Dongdong Zhang, Jiazhen Shang, Zhitao Zeng, Shouyu Chai, Xincong Lv, Zhimei Lv, Rong Wang   +7 more
wiley   +1 more source

Ablation of Mouse Selenium-Binding Protein 1 and 2 Elevates LDL by Disruption of Cholesterol Efflux and Lipid Metabolism. [PDF]

Int J Mol Sci
Zhao S, Song Y, Nakashima Y, Zou X, Koga T, Ishida T, Li R, Hirota Y, Tanaka Y, Ishii Y.   +9 more
europepmc   +1 more source

Dysbiosis in the Gut‐Liver Axis Is Associated With Low Bone Mass During Murine Cholestasis

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Dysbiosis in the gut‐liver axis drives a dysregulation in bile acid metabolism that increases bile acid efflux into systemic circulation and the bone marrow. Bile acid signaling in the marrow promotes osteoclastogenesis and suppresses osteoblastogenesis, which drives bone loss during cholestatic liver disease in mice. ABSTRACT The gut‐liver axis is the
Brooke Hutchison, Jamie Fornsaglio, Ridgeway Case IV, Pam Cornuet, Fu‐Ying Qin, Xiaochao Ma, Kari Nejak‐Bowen, Matthew D. Carson   +7 more
wiley   +1 more source

Clinical remission in newly diagnosed type 1 diabetes mellitus and HDL function on cholesterol efflux capacity: prospective InLipoDiab1 study. [PDF]

Endocr Connect
Uruska A, Mietkiewska-Dolecka M, Grzelka-Wozniak A, Flotynska J, Saldanha S, Rohatgi A, Zozulinska-Ziolkiewicz D.   +6 more
europepmc   +1 more source

Instant Membrane Stabilization by Damage‐Triggered Actin Polymerization in Giant Unilamellar Vesicles

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
Damage‐triggered actin polymerization stabilizes membrane pores in giant unilamellar vesicles (GUVs). Membrane poration drives divalent cation influx, inducing rapid F‐actin assembly at the defect site. The resulting actin plug mechanically arrests pore expansion and preserves vesicle morphology, recapitulating the “plugging” phase of single‐cell ...
Huong Thanh Nguyen, Sang Ho Lee, Chang Ho Kim, Kwanwoo Shin   +3 more
wiley   +1 more source

<i>Ex vivo</i> expanded human regulatory T cells promote cholesterol efflux and PON1 expression in oxLDL-exposed macrophages via gap junction-mediated cAMP transfer. [PDF]

Front Immunol
Albany CJ, Mastronicola D, Popov M, Stroukov W, Wierzbicki AS, Martinez-Nunez RT, Lombardi G, Scottà C.   +7 more
europepmc   +1 more source

Heterocyclic‐Fused Squaramides: Anionophores With Antimicrobial Activity

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
Supramolecular medicinal chemistry has allowed for the development of novel drugs for the treatment of cystic fibrosis, and in the fight against cancer. However, little has been done to develop these as antimicrobial agents. Here, we describe the development of novel chemical tools to further develop supramolecular methods to combat the global plight ...
Luke Edward Brennan, Chris Samuel Hawes, Kevin Kavanagh, Robert Brian Peter Elmes   +3 more
wiley   +1 more source