Results 131 to 140 of about 18,706 (235)

Bilateral Adrenal Calcifications as an Imaging Clue to Wolman Disease in Early Infancy: A Case Report. [PDF]

Cureus
Niño JC, Caicedo CA, Cárdenas J.
europepmc   +1 more source

Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice

The Journal of Physiology, EarlyView.
Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild, Valdemar Brimnes Ingemann Johansen, Christoffer Clemmensen, Pablo Ranea‐Robles   +3 more
wiley   +1 more source

Codon-optimized <i>Npc1</i> mRNA corrects Niemann-Pick type C1 disease phenotypes <i>in vitro</i> and <i>in vivo</i>. [PDF]

Mol Ther Nucleic Acids
Koufer ER, Townsend A, Na Y, Correia AB, Latham NK, Pathmasiri KC, Ilnytska O, Storch J, Sullivan KA, Halseth T, Kunkel TJ, Phillippi ES, Lieberman ML, Cologna SM, Lieberman AP, Jacobson DA, Schwendeman AS, Schultz ML.   +17 more
europepmc   +1 more source

Adaptations of glucagon‐like peptide‐1 receptor agonist‐induced weight loss, drivers of weight regain and future directions of therapeutics

The Journal of Physiology, EarlyView.
Abstract figure legend During GLP‐1RA treatment reduced appetite and energy intake, delayed gastric emptying, decreased visceral fat mass and improved glycaemic control contribute to weight loss. After treatment cessation these benefits are partially or completely reversed, resulting in weight regain, accompanied by increased appetite and energy intake,
Camille E. M. Piguet, Rosie Nucci, Jacqueline L. Beaudry   +2 more
wiley   +1 more source

The endo-lysosomal-lipid axis: bidirectional interactions between membrane trafficking dysfunction and lipid metabolic disorders. [PDF]

Front Cell Dev Biol
Du Y, Li L, Du M, Xu Z, Zhang X, Cao W.
europepmc   +1 more source

Mitochondrial permeability transition in skeletal muscle phenocopies muscle alterations seen in cancer cachexia and other wasting conditions

The Journal of Physiology, EarlyView.
Abstract figure legend Skeletal muscle wasting conditions are characterized by muscle fibre atrophy, mitochondrial respiratory dysfunction, mitochondrial depletion and fragmentation of acetylcholine receptor (AChR) cluster at the neuromuscular junction.
Maya Semel, Cole Lukasiewicz, Sarah Skinner, Mark R. Viggars, Sung Gi Noh, Martin Picard, Abbey‐Gale Mannings, Michael S. Cohen, Dennis W. Wolan, Terence E. Ryan, Russell T. Hepple   +10 more
wiley   +1 more source

Isoleucine and valine promote prostate cancer progression via propionyl-CoA-mediated cholesterol metabolism. [PDF]

Nat Metab
Li Z, Liu S, Jin W, Xiao L, Kester O, Bullen N, Chen X, Chan UI, Owiredu J, Li Z, Khan R, Endress J, Shafer M, Low V, Koundouros N, Cho S, Barbieri C, Guo CJ, Blenis J.   +18 more
europepmc   +1 more source

Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia. [PDF]

Arterioscler Thromb Vasc Biol, 2013
Stitziel NO, Fouchier SW, Sjouke B, Peloso GM, Moscoso AM, Auer PL, Goel A, Gigante B, Barnes TA, Melander O, Orho-Melander M, Duga S, Sivapalaratnam S, Nikpay M, Martinelli N, Girelli D, Jackson RD, Kooperberg C, Lange LA, Ardissino D, McPherson R, Farrall M, Watkins H, Reilly MP, Rader DJ, de Faire U, Schunkert H, Erdmann J, Samani NJ, Charnas L, Altshuler D, Gabriel S, Kastelein JJ, Defesche JC, Nederveen AJ, Kathiresan S, Hovingh GK, National Heart, Lung, and Blood Institute GO Exome Sequencing Project.   +39 more
europepmc   +1 more source

Implementation of Nano Flow Chromatography Coupled to Mass Spectrometry as a Reliable and Sensitive Discovery Lipidomics Platform

Rapid Communications in Mass Spectrometry, Volume 40, Issue 23, 15 December 2026.
ABSTRACT Rationale Untargeted lipidomics is commonly performed at analytical flow rates, which consume more solvent and may require higher on‐column sample loads when sensitivity is limited by analyte abundance. Nano flow separations use lower flow rates and sample loads, reducing solvent consumption and facilitating improved electrospray ionization ...
Ciara J. Sallowicz, Thiago Mattos, Rahul R. Deshpande, Bashar Amer, Susan S. Bird   +4 more
wiley   +1 more source

A Subset of Caveolin-1 Interacts with a Fraction of Acyl-CoA:Cholesterol Acyltransferase 1 (ACAT1/SOAT1) at an Endoplasmic Reticulum Subdomain to Attenuate Cholesteryl Ester Biosynthesis. [PDF]

Biomolecules
Chang CCY, Fujimoto T, Yamauchi Y, Urano Y, Chang TY.   +4 more
europepmc   +1 more source