Cholesterol esterification and p53-mediated tumor suppression [PDF]
Exploration of Targeted Anti-tumor Therapy, 2023 Many human cancers carry missense mutations in or deletions of the tumor protein 53 (TP53) tumor suppressor gene. TP53’s product, p53 regulates many biological processes, including cell metabolism. Cholesterol is a key lipid needed for the maintenance of
Youjun Li +2 more
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Cholesterol oxides inhibit cholesterol esterification by lecithin: cholesterol acyl transferase [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2009 Cholesterol oxides are atherogenic and can affect the activity of diverse important enzymes for the lipidic metabolism. The effect of 7β-hydroxycholesterol, 7-ketocholesterol, 25-hydroxycholesterol, cholestan-3β,5α,6β-triol,5,6β ...
Eder de Carvalho Pincinato +2 more
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Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease [PDF]
Alzheimer’s Research & Therapy, 2023 Objective The purpose of this study was to evaluate cholesterol esterification and HDL subclasses in plasma and cerebrospinal fluid (CSF) of Alzheimer’s disease (AD) patients.
Marta Turri +14 more
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Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-β [PDF]
Journal of Experimental Neuroscience, 2017 Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrP C ) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A 2 (cPLA 2 )
Clive Bate
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Deficient Cholesterol Esterification in Plasma of apoc2 Knockout Zebrafish and Familial Chylomicronemia Patients. [PDF]
PLoS One, 2017 Hypertriglyceridemia is an independent risk factor for cardiovascular disease. Apolipoprotein C-II (APOC2) is an obligatory cofactor for lipoprotein lipase (LPL), the major enzyme catalyzing plasma triglyceride hydrolysis.
Liu C, Gaudet D, Miller YI.
europepmc +3 more sources
Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer. [PDF]
Oncogene, 2016 Cancer cells are known to execute reprogramed metabolism of glucose, amino acids and lipids. Here, we report a significant role of cholesterol metabolism in cancer metastasis. By using label-free Raman spectromicroscopy, we found an aberrant accumulation
Li J +10 more
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P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis. [PDF]
Hepatology, 2023 Background and Aims: Cholesterol ester (CE) biosynthesis and homeostasis play critical roles in many cancers, including HCC, but their exact mechanistic contributions to HCC disease development require further study. Approach and Results: Here, we report on a proposed role of tumor ...
Zhu Y +10 more
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Increased plasma cholesterol esterification by LCAT reduces diet-induced atherosclerosis in SR-BI knockout mice[S] [PDF]
Journal of Lipid Research, 2015 LCAT, a plasma enzyme that esterifies cholesterol, has been proposed to play an antiatherogenic role, but animal and epidemiologic studies have yielded conflicting results.
Seth G. Thacker +14 more
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Cholesterol esterification inhibition and imatinib treatment synergistically inhibit growth of BCR-ABL mutation-independent resistant chronic myelogenous leukemia. [PDF]
PLoS One, 2017 Since the advent of tyrosine kinase inhibitors (TKIs) such as imatinib, nilotinib, and dasatinib, chronic myelogenous leukemia (CML) prognosis has improved greatly. However, ~30-40% of patients develop resistance to imatinib therapy.
Bandyopadhyay S +6 more
europepmc +5 more sources
Journal of Lipid Research, 1983 Rabbits were fed either 10% coconut oil, 10% coconut oil and 1% beta-sitosterol, 10% coconut oil and 1% cholesterol, or 10% coconut oil and 1% beta-sitosterol plus 1% cholesterol for 4 weeks.
F J Field, S N Mathur
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