Results 101 to 110 of about 30,189 (224)
Biology, 2014 We have previously shown that GFP-tagged human ABCG1 on the plasma membrane (PM) and in late endosomes (LE) mobilizes sterol on both sides of the membrane lipid bilayer, thereby increasing cellular cholesterol efflux to lipid surfaces.
Edward B. Neufeld +6 more
doaj +1 more source
Quinic Acid and Synthetic Derivatives in Medicinal Chemistry
ChemMedChem, Volume 21, Issue 5, 13 March 2026.Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel +2 more
wiley +1 more source
Journal of Lipid Research, 1987 Acyl coenzyme A:cholesterol acyl transferase and/or cholesterol esterase may regulate the esterification and absorption of exogenous cholesterol. To assess this, mucosal acyl coenzyme A:cholesterol acyl transferase activity was inhibited selectively with
L L Gallo, J A Wadsworth, G V Vahouny
doaj +1 more source
ChemSusChem, Volume 19, Issue 5, 13 March 2026.This study presents a practical aerobic photochemical strategy for the upcycling of polystyrene waste, combining bromine radical mediation with InBr3 catalysis. The approach efficiently depolymerizes diverse PS materials under mild conditions, yielding benzoic acid and enabling downstream production of value‐added compounds. The photochemical upcycling
Lydia Lavrenti +3 more
wiley +1 more source
Hepatic VLDL secretion : DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2 [PDF]
, 2019 We investigated whether, in view of its activity being expressed on both aspects of the endoplasmic reticulum (ER; dual membrane topology), diacylglycerol acyltransferase 1 (DGAT1) plays a distinctive role in determining the triglyceride (TAG) content of
Adya, Raghu +3 more
core +1 more source
Journal of Lipid Research, 1996 The effects of cholesteryl ester transfer protein (CETP) on the distribution of apolipoprotein (apo) A-I between high density lipoprotein (HDL) subspecies and its impact on efflux and esterification of cell-derived cholesterol was studied in transgenic ...
O L Francone, L Royer, M Haghpassand
doaj +1 more source
Ezetimibe therapy: mechanism of action and clinical update. [PDF]
, 2012 The lowering of low-density lipoprotein cholesterol (LDL-C) is the primary target of therapy in the primary and secondary prevention of cardiovascular events.
Dayspring, Thomas D +2 more
core +1 more source
Journal of Lipid Research, 1990 A lipoprotein particle designated A-LDL, which contains apolipoprotein B (apoB) and which is the size of plasma low density lipoproteins (LDL), was isolated from homogenates of human aortic athersclerotic plaques by a combination of affinity ...
R E Morton, G A West, H F Hoff
doaj +1 more source
ACAT1, Cav-1, and PrP expression in brains and skin fibroblasts from Sarda breed sheep with scrapie-resistant and scrapie-susceptible genotype. [PDF]
Scrapie is an infective ovine neurodegenerative disease; the only identified component of the infectious agent being an aberrant isoform (PrPSc) of the cellular prion protein (PrPC). So far, no means for ante-mortem diagnosis are available for Scrapie as
Alessandra Pani +9 more
core +1 more source
Genetic obesity increases pancreatic expression of mitochondrial proteins which regulate cholesterol efflux in BRIN-BD11 insulinoma cells [PDF]
, 2019 Pancreatic β-cells are sensitive to fluctuations in cholesterol content, which can damage the insulin secretion pathway, contributing to the aetiology of type 2 diabetes mellitus.
Caridis, Anna Maria +4 more
core +1 more source