Results 11 to 20 of about 30,189 (224)

Impact of serum cholesterol esterification rates on the development of diabetes mellitus in a general population [PDF]

Lipids in Health and Disease, 2018
s Background Lecithin:cholesterol acyltransferase (LCAT) plays an important role in cholesterol esterification in serum. Serum LCAT activity is elevated in patients with serum high triglyceride and low high-density lipoprotein-cholesterol (HDL-C ...
Shin-ichiro Tanaka, Yoshio Fujioka, Takeshi Tsujino, Tatsuro Ishida, Ken-ichi Hirata   +4 more
doaj   +2 more sources

25-Hydroxycholesterol modulates microglial function and exacerbates Alzheimer’s disease pathology: mechanistic insights and therapeutic potential of cholesterol esterification inhibition [PDF]

Journal of Neuroinflammation
This study investigates the role of 25-hydroxycholesterol (25HC), a metabolite produced by cholesterol hydroxylase encoded by the Ch25h gene, in modulating microglial function and its potential implications in Alzheimer’s disease (AD) pathology.
Hayoung Choi, Haeng Jun Kim, Sang-Eun Lee, Hyun Ho Song, Jieun Kim, Jihui Han, June-Hyun Jeong, Do Yup Lee, Sunghoe Chang, Inhee Mook-Jung   +9 more
doaj   +2 more sources

Regulation of cholesterol esterification by micellar cholesterol in CaCo-2 cells

Journal of Lipid Research, 1987
The regulation of acylcoenzyme A:cholesterol acyltransferase (ACAT) activity by cholesterol was studied in an established enterocyte cell line. CaCo-2 cells were grown in culture to confluency and dome formation.
F J Field, E Albright, S N Mathur
doaj   +3 more sources

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]

, 2008
Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Silva, Liliana M. R., Lütjohann, Dieter, Hamid, Penny, Velasquez, Zahady D., Kerner, Katharina, Larrazabal, Camilo, Failing, Klaus, Hermosilla, Carlos, Taubert, Anja   +8 more
core   +2 more sources

Lecithin:cholesterol acyltransferase (LCAT) mass; its relationship to LCAT activity and cholesterol esterification rate.

Journal of Lipid Research, 1981
The relationship between plasma lecithin:cholesterol acyltransferase mass and enzyme activity and between mass and plasma cholesterol esterification rate was determined in 25 adult volunteers without overt disease (14 normolipidemic and 11 hyperlipidemic)
J J Albers, C H Chen, J L Adolphson
doaj   +1 more source

Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice

Journal of Lipid Research, 1997
Cholesterol esterification is involved in the regulation of cellular cholesterol content and has been hypothesized to play a role in important physiologic processes including intestinal cholesterol absorption, hepatic lipoprotein production, and ...
V Meiner, C Tam, M D Gunn, L M Dong, K H Weisgraber, S Novak, H M Myers, S K Erickson, R V Farese, Jr   +8 more
doaj   +1 more source

The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-ß [PDF]

, 2017
Cholesterol is required for the formation and function of some signalling platforms. In synaptosomes, amyloid-β (Aβ) oligomers, the causative agent in Alzheimer's disease, bind to cellular prion proteins (PrPC) resulting in increased cholesterol ...
Anderson, Bate, Bate, Bate, Baxter, Bryleva, Chan, Chang, Chen, Chen, Chiarini, Chiesa, Dunkley, Gaudreault, Gilch, Giuffrida, Gocze, Gylys, Hammond, Herms, Hosie, Kaneko, Kawarabayashi, Koch, Laurén, Linden, Linetti, Lingwood, Lingwood, London, Maglio, Maxfield, Mc Donald, McLean, Montine, Moskowitz, Mouillet-Richard, Nalefski, Naslavsky, Osborne, Pani, Puglielli, Rajendran, Robinet, Ryan, Schroeder, Selkoe, Shankar, Sharma, Simons, Solforosi, Stahl, Sugiyama, Suzuki, Taraboulos, Walsh, Williamson, Yang   +57 more
core   +2 more sources

Cholesterol esterification in rabbit plasma [PDF]

Biochemical Journal, 1969
1. When [4−14C]cholesterol, attached to β-globulin or dispersed with Tween 20, was incubated with fresh rabbit (New Zealand albino females) plasma, 30–47% esterification was observed. The optimum pH was 6·8. This esterification was accomplished by the transfer of fatty acids from the C-2 position of lecithin (phosphatidylcholine) to cholesterol.
openaire   +2 more sources

Movement of 25-hydroxycholesterol from the plasma membrane to the rough endoplasmic reticulum in cultured hepatoma cells.

Journal of Lipid Research, 1995
Oxysterols serve as both substrates and signal molecules in the cholesterol-utilizing pathways of mammalian cells. Their distribution and movement within these cells, however, have not been well characterized; therefore we have undertaken such an ...
Y Lange, J Ye, F Strebel
doaj   +1 more source

Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells: inhibition of cholesterol esterification by oxidatively modified low density lipoprotein.

Journal of Lipid Research, 1989
The rate of degradation of oxidatively modified low density lipoprotein (Ox-LDL) by human endothelial cells was similar to that of unmodified low density lipoprotein (LDL), and was approximately 2-fold greater than the rate of degradation of acetylated ...
I Jialal, A Chait
doaj   +1 more source