Results 81 to 90 of about 30,189 (224)

Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia [PDF]

, 2017
Numerous analyses have explored the role of statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke.
AlSulaiman, Wafa
core  

Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study [PDF]

, 2010
Background Disrupted cholesterol regulation leading to increased circulating and membrane cholesterol levels is implicated in many age-related chronic diseases such as cardiovascular disease (CVD), Alzheimer's disease (AD), and cancer.
Rishikesh Mankidy, Pearson WK Ahiahonu, Hong Ma, Dushmanthi Jayasinghe, Shawn A Ritchie, Mohamed A Khan, Khine K Su-Myat, Paul L Wood, Dayan B Goodenowe   +8 more
core   +2 more sources

Songorine inhibits mitophagy in chronic heart failure via the TBC1D15/Fis1/Rab7A pathway

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Songorine (SGR) is an alkaloid extracted from Aconitum carichaelii Debx. and has a demonstrated role in cardiac dysfunction. Chronic heart failure (CHF) is a severe clinical syndrome leading to functional impairment and death, primarily due to the deterioration of energy metabolism in cardiomyocytes. However, the precise
Wenxiu Liu, Xingju Zou, Yang Zheng, Chen Sun, Cheng Peng   +4 more
wiley   +1 more source

CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption.

Journal of Lipid Research, 1989
CL 277,082 (I) was found to be a potent inhibitor of acyl CoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) in microsomes from a variety of tissues with IC50 values of 0.14 microM for intestinal mucosal microsomes, 0.74 microM for liver, and 1.18 ...
E E Largis, C H Wang, V G DeVries, S A Schaffer   +3 more
doaj   +1 more source

Nicotinic Acid Accelerates HDL Cholesteryl Ester Turnover in Obese Insulin-Resistant Dogs. [PDF]

PLoS ONE, 2015
Nicotinic acid (NA) treatment decreases plasma triglycerides and increases HDL cholesterol, but the mechanisms involved in these change are not fully understood.
Jérôme Le Bloc'h, Véronique Leray, Hassan Nazih, Olivier Gauthier, Samuel Serisier, Thierry Magot, Michel Krempf, Patrick Nguyen, Khadija Ouguerram   +8 more
doaj   +1 more source

Investigation into the delivery and evaluation of a unique Avena sativa (Oat) Lipid Extract on skin barrier using LC‒MS/MS, Raman spectroscopy, immunostaining analysis and skin efficacy

International Journal of Cosmetic Science, EarlyView.
Abstract Objectives Oat lipids are rich in ceramides. In this investigation, we analysed the delivery of a specific Oat Lipid Extract derived from Avena sativa, comprising ‘skin identical’ ratios of fatty acids, ceramides and cholesterol/sterol. This investigation is the first reported investigation of oat lipids utilizing Raman spectroscopy for the ...
E. Gombert, C. Dewis
wiley   +1 more source

Stimulation of esterified cholesterol accumulation in tissue culture cells exposed to high density lipoproteins enriched in free cholesterol.

Journal of Lipid Research, 1978
Human high density lipoprotein enriched in free cholesterol was obtained by exposing the lipoprotein to lipid dispersions having a free cholesterol/lecithin molar ratio greater than two.
G H Rothblat, L Y Arbogast, E K Ray
doaj   +1 more source

A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport [PDF]

, 2015
Sterol traffic between the endoplasmic reticulum (ER) and plasma membrane (PM) is a fundamental cellular process that occurs by a poorly understood non-vesicular mechanism. We identified a novel, evolutionarily diverse family of ER membrane proteins with
Calderón-Noreña, DM, Cockcroft, S, Gatta, AT, Levine, TP, Menon, AK, Sere, YY, Wong, LH   +6 more
core   +1 more source

A century of vitamin E research: The innovative journey from basic biology to synthetic bio‐manufacturing

Journal of Integrative Plant Biology, EarlyView.
For a century, Vitamin E has been studied for its health benefits. This review traces its journey from basic biological discovery, and the recent identification of its link to chlorophyll degradation, to the modern era of sustainable microbial manufacturing, highlighting the innovative technologies that define its future production.
Ruiqi Zhang, Yuqing Ren, Yuehe Zhao, Hongyan Zheng, Yanzhong Luo, Yuan Liu, Lei Wang, Lan Zhang   +7 more
wiley   +1 more source

Acyl-CoA:cholesterol acyltransferase in human small intestine: its activity and some properties of the enzymic reaction.

Journal of Lipid Research, 1981
Esterification of endogenous cholesterol in human small intestinal mucosa by acyl-CoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) was studied using [1-14C]oleoyl-CoA as substrate. The reaction was linear for 2 min only.
P Helgerud, K Saarem, K R Norum
doaj   +1 more source