Results 201 to 210 of about 588,707 (355)

Cholesterol metabolism [PDF]

Biochemical Journal, 1938
openaire   +1 more source

Corrigendum: Alterations in Cholesterol Metabolism and Genetics as Key Players in Mild Cognitive Impairment [PDF]

, 2019

openalex   +1 more source

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu, Shule Zhang, Ruofan Du, Lina Kang, Guodong Zhao, Xue Bao, Haochi Yang, Ziqing Xie, Tianyu He, Huiyong Sun, Haiping Hao, Lijuan Cao   +11 more
wiley   +1 more source

Targeting Aurora kinase B regulates cholesterol metabolism and enhances chemoimmunotherapy in cholangiocarcinoma. [PDF]

Gut
Liu F, Chen W, Zhang Z, Zeng W, Hu H, Ning S, Liao Z, Liu Y, Zhang H, Fu Q, Zhang B, Chen X, Zhang W, Zhang Z.   +13 more
europepmc   +1 more source

The Metabolism of Cholesterol [PDF]

Postgraduate Medical Journal, 1959
openaire   +2 more sources

Plant Sterols, Cholesterol Metabolism, and Cognitive Decline in the Older People: A Population-Based Study

, 2022
Christopher Clark, Mehdi Gholam‐Rezaee, Leonardo Zullo, Anja Kerksiek, Enrique Castelao, Armin von Gunten, Martin Preisig, Dieter Lütjohann, Julius Popp   +8 more
openalex   +1 more source

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier Damage

Advanced Science, EarlyView.
Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, Xianzhi Meng   +10 more
wiley   +1 more source

Cholesterol metabolism shapes immune low-response states in LUAD: a multi-omics cholesterol metabolism signature predicts immunotherapy benefit and identifies DHCR7 as a therapeutic target. [PDF]

Front Immunol
Du M, Zheng J, Zhou G, Zhuang Y, Huang C, Ye W.   +5 more
europepmc   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Cholesterol metabolism on stem cell fate determination: a frontier horizon. [PDF]

Stem Cell Res Ther
Xu B, Li L, Wei Q, Wang Y, Huang H, Pang T, Wei Z, Zheng G, Li Y.   +8 more
europepmc   +1 more source