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Cholesterol metabolism and embryogenesis
Trends in Genetics, 1998Although cholesterol has long been known to be an essential component of cell membranes in vertebrate organisms, recent studies have suggested that cholesterol plays a crucial role in specific processes during embryonic development, including the covalent modification of Hedgehog proteins.
Robert V Farese, Joachim Herz
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Phytosterols and cholesterol metabolism
Current Opinion in Lipidology, 2004Phytosterols are plant sterols structurally similar to cholesterol that act in the intestine to lower cholesterol absorption. Because they have very low systemic absorption and are already present in healthy diets, increasing the intake of phytosterols may be a practical way to reduce coronary heart disease with minimum risk.Phytosterols displace ...
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Cholesterol metabolism in the baboon
Lipids, 1968AbstractStudies on the transport of exogenous and endogenous cholesterol in the baboon have been carried out using14C‐acetate,14C‐mevalonic acid, or3H‐cholesterol. The results suggest the following characteristics of cholesterol metabolism in the baboon: the serum α‐ and β‐lipoproteins show no preference in the transport of exogenous or endogenous ...
I L, Shapiro +3 more
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Cholesterol metabolism in the brain
Current Opinion in Lipidology, 2001The central nervous system accounts for only 2% of the whole body mass but contains almost a quarter of the unesterified cholesterol present in the whole individual. This sterol is largely present in two pools comprised of the cholesterol in the plasma membranes of glial cells and neurons and the cholesterol present in the specialized membranes of ...
J M, Dietschy, S D, Turley
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Genetics and cholesterol metabolism
Current Opinion in Lipidology, 1996The regulation of cholesterol metabolism by both genetic and environmental factors seems to be very complex. The recent research approach focusing on the genetic control of many key regulatory processes of cholesterol homeostasis has, however, started to elucidate the importance of genetic variation in susceptibility to a number of common clinical ...
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CHOLESTEROL METABOLISM IN THE ADRENAL CORTEX
Journal of Steroid Biochemistry, 1983Adrenal cortical mitochondria contain a mixed function oxidase capable of converting cholesterol to pregnenolone; this enzyme requires NADPH, oxygen and cholesterol. This cholesterol side chain cleavage enzyme system contains a Flavoprotein, an iron sulphur protein and a specific cytochrome P450 termed cytochrome P450scc.
G S, Boyd +3 more
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Cholesterol metabolism deficiency
2013Genetic defects in enzymes responsible for cholesterol biosynthesis have emerged as important causes of congenital dysmorphology and retardation syndromes. Cholesterol is an important constituent of the cell membrane of most eukaryotic cells, in myelin formation in the brain, spinal cord, and peripheral nervous system, and acts as the precursor for ...
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Cholesterol biosynthesis and metabolism
Cardiovascular Drugs and Therapy, 1992Cholesterol plays an essential role in cell membrane synthesis and in cell growth and differentiation. In mammalian cells, cholesterol can be synthesized from acetate precursors or taken up from dietary or exogenous sources. The major catabolic route for disposal of cholesterol involves conversion into excretable bile acids.
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INFLUENCE OF DIETARY CHOLESTEROL ON CHOLESTEROL METABOLISM*
Annals of the New York Academy of Sciences, 1968J D, Wilson, C A, Lindsey, J M, Dietschy
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