Results 221 to 230 of about 588,707 (355)

KDM5B cooperates with CRL4B complex to promote the tumorigenesis of ER+ breast cancer via regulating cholesterol metabolism. [PDF]

Cell Death Dis
Yang Y, Gao T, Yuan B, Hao X, Huo M, Hu T, Ma T, Zhang M, Zhang D, Teng X, Yu H, Huang W, Zhang J, Wang Y.   +13 more
europepmc   +1 more source

Assessment of biomarkers of cholesterol homeostasis and vitamin D metabolism in patients with colorectal cancer

, 2019
Sandra S. Vladimirov
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Multi-omics analysis reveals different cholesterol metabolism subtypes in colorectal cancer. [PDF]

Discov Oncol
Sun Y, Kong D, Zhang H, Fan J, Lu S, Yang W, Xiang R, Zhang Q, Pei W, Feng L, Zhang H.   +10 more
europepmc   +1 more source

CHOLESTEROL METABOLISM IN DISEASE [PDF]

BMJ, 1932
openaire   +2 more sources

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Cholesterol metabolism: molecular mechanisms, biological functions, diseases, and therapeutic targets. [PDF]

Mol Biomed
Cui D, Yu X, Guan Q, Shen Y, Liao J, Liu Y, Su Z.   +6 more
europepmc   +1 more source

Adhesion‐Related Macrophages Regulate Metabolic Homeostasis Through CAV‐1 Dependency

Advanced Science, EarlyView.
Adipose tissue harbors a distinct macrophage subpopulation, termed adhesion‐related macrophages (ARMs), which stably adhere to adipocytes. In obesity, ARMs represent the major expanding macrophage subset. They acquire material from adipocytes and rely on Caveolin‐1 for sustained lipid handling.
Wanyu Hu, Xiyan Liao, Limin Xie, Xiaoxiao Sun, Luodi Jing, Qin Zeng, Hongwei Jiang, Haowei Zhang, Lei Li, Fanqi Wang, Dandan Wang, Ying Mei, Yujin Din, Jianfeng Song, Wufuer Aini, Hui Zhou, Wanqin Xie, Helong Dai, Wei Liu, Joey Liu, Yan Cheng, Feng Liu, Willa A. Hsueh, Tuo Deng   +23 more
wiley   +1 more source

Lymphatic-stem cell crosstalk promotes tendon regeneration via Notch1-Srebp2-mediated cholesterol metabolism. [PDF]

Nat Commun
Chen L, Cai M, Lin S, Li M, Zhu Z, Zhang H, Zhao H, Xu C, Yang R.   +8 more
europepmc   +1 more source

Effect of 4-(4'-chlorobenzyloxy)benzyl nicotinate (KCD-232) on cholesterol metabolism in rats fed an amino acid imbalance diet.

, 1984
Kazumi Yagasaki, Kodo Okada, Kouichi Takagi, Tsutomu Irikura   +3 more
openalex   +2 more sources