Results 101 to 110 of about 441,731 (309)

Sterol 3β-glucosyltransferase biocatalysts with a range of selectivities, including selectivity for testosterone [PDF]

, 2013
The main objectives of this work were to characterise a range of purified recombinant sterol 3β-glucosyltransferases and show that rational sampling of the diversity that exists within sterol 3β-glucosyltransferase sequence space can result in a range of
Altschul, Anthony Flinn, Bellu, Bonsor, Cantarel, Coutinho, Doerks, Gary W. Black, Grille, Hansen, Hashimoto, Julian S. Northen, Justin J. Perry, Laemmli, Lemmon, Li, Lynn G. Dover, Madina, Madina, Meng Zhang, O'Reilly, Oku, Palcic, Poppenberger, Rabbani, Robertson, Vatsala Malik, Warnecke, Weijers, Yang, Zea   +30 more
core   +1 more source

Macrophage Membrane‐Cloaked, ROS‐Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome

Advanced Healthcare Materials, EarlyView.
The synthesis process of MM@PCD@QNPs and its potential mechanism for treating PCOS. (A) Assembly steps of MM@PCD@QNPs. (B) Synthesis and decomposition of MM@PCD@QNPs. (C) Potential therapeutic mechanisms of MM@PCD@QNPs for PCOS. PCD, PABP conjugated with DEX polymer; QUR, quercetin; CDI, N, N′‐carbonyldiimidazole; DEX, dextran; PABP, 4‐(hydroxymethyl ...
Wenzhu Li, Yu Guan, Nan Song, Feng Zhang, Zhimin Deng, Tailang Yin, Yanbing Yang, João Conde, Wenyi Jin, Zhinang Yin   +9 more
wiley   +1 more source

Baseline cholesterol absorption and the response to ezetimibe/simvastatin therapy: a post-hoc analysis of the ENHANCE trial[S]

Journal of Lipid Research, 2010
Subjects with increased cholesterol absorption might benefit more from statin therapy combined with a cholesterol absorption inhibitor. We assessed whether baseline cholesterol absorption markers were associated with response to ezetimibe/simvastatin ...
L. Jakulj, M.N. Vissers, A.K. Groen, B.A. Hutten, D. Lutjohann, E.P. Veltri, J.J.P. Kastelein   +6 more
doaj   +1 more source

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, EarlyView.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source

Sex Differences in the Hepatic Cholesterol Sensing Mechanisms in Mice

Molecules, 2013
Cholesterol is linked to many multifactorial disorders, including different forms of liver disease where development and severity depend on the sex. We performed a detailed analysis of cholesterol and bile acid synthesis pathways at the level of genes ...
Ingemar Björkhem, Damjana Rozman, Simon Horvat, Martina Perše, Gregor Lorbek   +4 more
doaj   +1 more source

The Unicellular State as a Point Source in a Quantum Biological System. [PDF]

, 2016
A point source is the central and most important point or place for any group of cohering phenomena. Evolutionary development presumes that biological processes are sequentially linked, but neither directed from, nor centralized within, any specific ...
Miller, William B, Torday, John S
core   +3 more sources

Effects of Liposome Composition and Size on Protein Corona Formation: Competitive Replacement of Abundant Proteins by High‐Affinity Proteins on the Liposome Surface

Advanced Healthcare Materials, EarlyView.
Coarse‐grained MD simulations capture the effects of liposome composition and size on protein adsorption onto the liposome surface, in agreement with experiments. Liposome‐protein interactions are energetically stabilized by the replacement of abundant proteins with high‐affinity proteins on the liposome surface through electrostatic and hydrophobic ...
Hwankyu Lee
wiley   +1 more source

Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin

Journal of Lipid Research, 1999
The concept that hepatic cholesterol synthesis regulates hepatocyte assembly and secretion of apoB-containing lipoproteins remains controversial. The present study was carried out in HepG2 cells to examine the regulation of apoB secretion by the HMG-CoA ...
Lisa J. Wilcox, P. Hugh R. Barrett, Murray W. Huff   +2 more
doaj   +1 more source

Homozygous disruption of P450 side-chain cleavage (CYP11A1) is associated with prematurity, complete 46,XY sex reversal, and severe adrenal failure [PDF]

, 2005
Disruption of the P450 side-chain cleavage cytochrome (P450scc) enzyme due to deleterious mutations of the CYP11A1 gene is thought to be incompatible with fetal survival because of impaired progesterone production by the fetoplacental unit.
Achermann, JC, Hiort, O, Holterhus, PM, Hoppe, U, Marschke, C, Partsch, CJ, Riepe, FG, Struve, D, Werner, R   +8 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source