Results 241 to 250 of about 444,409 (302)

Liposomal Delivery of L‐2‐Hydroxyglutarate for Targeting Epigenetic Dysregulation in Osteoarthritis

Advanced NanoBiomed Research, EarlyView.
Osteoarthritis involves cartilage degeneration, inflammation, and epigenetic dysregulation. A liposomal formulation of the TET1 inhibitor L‐2‐hydroxyglutarate to overcome rapid joint clearance was developed. The formulation showed good physicochemical properties, reduced inflammatory and catabolic gene expression in chondrocytes, and alleviated ...
Denise Murgia, Akshay Pandey, Raffaele Spanò, Bianca Martins Estevão, Roberto Palomba, Greta Avancini, Tamaghna Gupta, Ana Maria Lopez Estevez, Stuart B. Goodman, Nidhi Bhutani, Paolo Decuzzi   +10 more
wiley   +1 more source

A Doxorubicin‐Loaded Liposomes Baghdadite System for Localized Osteosarcoma Therapy and Bone Regeneration

Advanced NanoBiomed Research, EarlyView.
This study presents a multifunctional Baghdadite ceramic implant integrating doxorubicin‐loaded liposomes via ion‐assisted plasma polymer coating for localized osteosarcoma therapy. The platform enables drug retention, sustained release, tumor cell inhibition, osteoconductivity, and antibacterial activity, offering a mechanically robust strategy for ...
Sally Kortam, Zufu Lu, Iman Roohani, Ghazal Shineh, Leila Mamizadeh Janghour, Huu Nguyen Ngoc, Pooria Lesani, Behnam Akhavan, Hala Zreiqat   +8 more
wiley   +1 more source

Single‐Injection Multi‐Omics Analysis by Direct Infusion Mass Spectrometry

Angewandte Chemie, EarlyView.
A high‐throughput direct infusion mass spectrometry platform, enabled by gas‐phase ion mobility separation, supports single‐injection analysis of peptides, polar metabolites, and lipids. Coupled with custom software, it identified ∽1,300 proteins and ∽600 metabolites in ∽4.3 minutes per sample, and demonstrated broad utility in macrophage polarization ...
Yuming Jiang, Ivan Salladay‐Perez, Amanda Momenzadeh, Jesús Muñoz‐Estrada, Uktarsh Tripathi, Anthony J. Covarrubias, Jesse G. Meyer   +6 more
wiley   +1 more source

The constitutively active form of a key cholesterol synthesis enzyme is lipid droplet-localized and upregulated in endometrial cancer tissues. [PDF]

J Biol Chem
Coates HW, Nguyen TB, Du X, Olzomer EM, Farrell R, Byrne FL, Yang H, Brown AJ.   +7 more
europepmc   +1 more source

Transcriptional Dysregulation of Cholesterol Synthesis Underlies Hyposensitivity to GABA in the Ventral Tegmental Area During Acute Alcohol Withdrawal. [PDF]

Biol Psychiatry
You C, Krishnan HR, Chen Y, Zhang H, Drnevich J, Pinna G, Guidotti A, Glover EJ, Lasek AW, Grayson DR, Pandey SC, Brodie MS.   +11 more
europepmc   +1 more source

Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

Ionescu R, Nicaise AM, Reisz JA, Williams EC, Prasad P, Dzieciatkowska M, Stephenson D, Cubero MS, Pirvan L, Willis CM, Peruzzotti-Jametti L, Fossati V, Edenhofer F, Leonardi T, Frezza C, Mohorianu I, D’Alessandro A, Pluchino S.   +17 more
europepmc   +1 more source

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KETOCONAZOLE AND CHOLESTEROL SYNTHESIS

The Lancet, 1984
T A, Miettinen, V V, Valtonen
openaire   +4 more sources

CHOLESTEROL SYNTHESIS INHIBITORS IN HYPERLIPIDAEMIA

The Lancet, 1988
M J, Mol, P M, Stuyt, A F, Stalenhoef, A, van 't Laar   +3 more
openaire   +4 more sources