Results 221 to 230 of about 262,864 (261)
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On the control of cholesterol synthesis
Metabolism, 1973HE MORBID EXISTENCE of cholesterol within the walls of arteries represents the present prime threat to the physical well being of the Western world. Other modifying factors notwithstanding. its presence is the sine qua non of atherosclerosis. Extensive evidence from clinical, epidemiologic. and experimental derivations links cholesterol with this major
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Inhibition of Cholesterol Synthesis
The Journal of Nutrition, 1987Efforts to find inhibitors of cholesterol synthesis, which might act as hypocholesterolemic agents, have been going on for over 30 yr. One difficulty with this approach is that we are dealing with an integral metabolite rather than a foreign substance. It is thought that the ideal place for inhibition of synthesis would be a water-soluble intermediate ...
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Metabolite Regulation of Cholesterol Synthesis
Hospital Practice, 1985Strong circumstantial evidence supports the concept that 26-hydroxycholesterol is involved in regulating synthesis of its parent molecule. Different theories of feedback inhibition of a critical enzyme, HMG-CoA reductase, are discussed. Advances in mass spectrometry technology should make it possible to establish whether cholesterol or its metabolite ...
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Glycerol as an inhibitor of cholesterol synthesis
Canadian Journal of Biochemistry, 1968The supernatant from a homogenate of rat liver was incubated in a system containing 14C-acetate. The mixture was then saponified, the cholesterol isolated as the digitonide, and its radioactivity determined. When glycerol (water control) was a constituent of the incubation mixture, less radioactivity appeared in the digitonide.
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Fat feeding and cholesterol synthesis
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1967Abstract The feeding of fat has previously been shown to result in a decrease in fatty acid synthesis and an increase in cholesterol synthesis by the liver. Furthermore, it has been proposed that fatty acid synthesis is controlled by the inhibition of the ratelimiting acetyl-CoA carboxylase by long-chain fatty acyl-CoA derivatives with a consequent ...
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2018
The phenotype of some inborn errors of cholesterol biosynthesis may present with symptoms suggestive of adrenal or gonadal steroid disorders. An overview of cholesterol biosynthesis is presented with more in-depth coverage of two disorders in which a urine steroid profile can play a role in the diagnosis: cytochrome P450 oxidoreductase deficiency and ...
Francis Lam, Oliver Clifford-Mobley
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The phenotype of some inborn errors of cholesterol biosynthesis may present with symptoms suggestive of adrenal or gonadal steroid disorders. An overview of cholesterol biosynthesis is presented with more in-depth coverage of two disorders in which a urine steroid profile can play a role in the diagnosis: cytochrome P450 oxidoreductase deficiency and ...
Francis Lam, Oliver Clifford-Mobley
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Cholesterol Synthesis Disorders
2014Cholesterol has several essential functions in normal cell physiology. In addition to being a major component of cellular membranes, cholesterol serves as the precursor of bile acids and steroid hormones and plays an important role in embryonic development.
Richard I. Kelley, Lisa Kratz
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Disorders of Cholesterol Synthesis
2000Only four of over 30 possible defects of cholesterol biosynthesis have been described. Mevalonic aciduria due to mevalonate kinase deficiency is situated at the beginning of the pathway and compromises the production of nonsterol isoprenes in addition to cholesterol.
Georg F. Hoffmann, Dorothea Haas
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Cholesterol synthesis inhibitors inhibit more than cholesterol synthesis.
Kidney international. Supplement, 1994The beneficial effects of HMG-CoA reductase inhibition in models of progressive glomerular injury may not all be due to reductions in circulating lipoproteins and decreases in glomerular lipoprotein deposition. Indeed, HMG-CoA reductase inhibitors may have direct effects on glomerular mesangial cells that could explain the amelioration of renal injury.
B L, Kasiske +4 more
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KETOCONAZOLE AND CHOLESTEROL SYNTHESIS
The Lancet, 1984T A, Miettinen, V V, Valtonen
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