Results 111 to 120 of about 6,168 (166)

TGF-β2 drives lipid droplet accumulation in chondrocytes through the TβRI/p-smad3/fabp5 axis. [PDF]

J Biol Chem
Wei J, Pi C, Qi Y, Yang W, Sun J, Xu X, Xie J.   +6 more
europepmc   +1 more source

The endo-lysosomal-lipid axis: bidirectional interactions between membrane trafficking dysfunction and lipid metabolic disorders. [PDF]

Front Cell Dev Biol
Du Y, Li L, Du M, Xu Z, Zhang X, Cao W.
europepmc   +1 more source

Broad-Coverage Lipidomics Reveals Temporal Lipid Remodeling and Candidate Serum Biomarkers After Acute Spinal Cord Injury in Rats. [PDF]

Biomedicines
Zhao T, Huang H, Shi C, Zhang F, Wu Q, Li F, Xu K.   +6 more
europepmc   +1 more source

Phloretic Acid Improves Metabolic Dysfunction-Associated Steatotic Liver Disease in High-Fat Diet-Fed Mice. [PDF]

Molecules
Park S, Kim H, Jung UJ.
europepmc   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic-Therapeutic Directions of Cardiovascular Diseases. [PDF]

J Biochem Mol Toxicol
Xie P, Zeng Q, Wang H, She M.
europepmc   +1 more source

From lipid overload to autophagy collapse: how lipid dysregulation drives chronic inflammation and metabolic disease. [PDF]

Inflamm Res
Fomin M, Zapf K, Schieffer E, Freitag J, Bange G, Schieffer B.   +5 more
europepmc   +1 more source

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Structural bases of Wolman disease and cholesteryl ester storage disease

Molecular Genetics and Metabolism, 2012
To elucidate the bases of Wolman disease (WD) and cholesteryl ester storage disease (CESD) from the viewpoint of enzyme structure, we constructed a structural model of human lysosomal acid lipase (LAL) using molecular modeling software Modeller. The results revealed that the residues responsible for WD/CESD tend to be less solvent-accessible than ...
Toshihiro Suzuki, Kazuki Ohno
exaly   +3 more sources

Liver Transplantation for Cholesteryl Ester Storage Disease

Journal of Pediatric Gastroenterology and Nutrition, 1991
SummaryThis case describes a patient with cholesteryl ester storage disease who underwent liver transplantation for progressive cirrhosis, portal hypertension, ascites, and uncontrollable gastrointestinal bleeding. Four and one‐half years posttransplant, her growth improved, cholesterol levels have returned to normal, and she is clinically well except ...
George D Ferry
exaly   +3 more sources

Cholesteryl Ester Storage Disease: Case Report during Childhood

Pediatric and Developmental Pathology, 1999
Cholesteryl ester storage disease (CESD) is rare and characterized by accumulation of cholesteryl esters and triglycerides in many tissues due to the deficiency of lysosomal acid lipase. We report a 3½-year-old child with CESD. The diagnosis was indicated by liver biopsy and confirmed by reduced acid lipase activity in leukocytes.
Hasan Özen, Aysel Yüce, Figen Gurakan
exaly   +4 more sources