Results 121 to 130 of about 32,808 (269)

Digital Biomarkers for Precision Early Detection of Lung Cancer: Integrating AI‐Driven Multi‐Omics Into Clinical Pathways

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Lung cancer remains the leading cause of cancer‐related mortality worldwide, highlighting the urgent need for earlier detection within real‐world screening and patient management pathways. Recent advances in multi‐omics technologies have created new opportunities for identifying biomarkers associated with early‐stage lung cancer ...
Fan Bu, Zhi‐Qiang Ling
wiley   +1 more source

Conversion of lipid transfer inhibitor protein (apolipoprotein F) to its active form depends on LDL composition

Journal of Lipid Research, 2011
Lipid transfer inhibitor protein (LTIP) exists in both active and inactive forms. Incubation (37°C) of plasma causes LTIP to transfer from a 470 kDa inactive complex to LDL where it is active. Here, we investigate the mechanisms underlying this movement.
Richard E. Morton, Diane J. Greene
doaj   +1 more source

Lipidomic Analysis of Plasma Extracellular Vesicles from Adiponectin Deficient Mice or Metabolic Syndrome Patients Reveals Pro‐Oxidative and Pro‐Inflammatory Lipid Signatures Correlating with Metabolic Dysfunction

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Adiponectin deficiency remodels the lipid composition of plasma extracellular vesicles (EV), enriching polyunsaturated phospholipids and reducing lysophospholipids. These remodelled EV impact oxidative, inflammatory and metabolic function in recipient cells.
Sungji Cho, Hye Kyoung Sung, Khang Nguyen, Yubin Lei, Sivaporn Wannaiampikul, Brian Lee, Eddie Tam, Yihan Luo, Evgeniy V. Petrotchenko, Christoph H. Borchers, Kacey J. Prentice, Scott A Summers, Dylan Burger, Gary Sweeney   +13 more
wiley   +1 more source

Human plasma phospholipid transfer protein increases the antiatherogenic potential of high density lipoproteins in transgenic mice [PDF]

, 2000
Plasma phospholipid transfer protein (PLTP) transfers phospholipids between lipoprotein particles and alters high density lipoprotein (HDL) subfraction patterns in vitro, but its physiological function is poorly understood ...
Berg, P.M. (Paul) van den, Crom, M.P.G. (Rini) de, Ehnholm, S. (Sonja), Gent, T. (Teus) van, Grosveld, F.G. (Frank), Haperen, M.J. (Rien) van, Jauhiainen, M., Kamp, A.W.M. (Arthur) van der, Tol, A. (Arie) van, Vermeulen, P. (Pieter)   +9 more
core  

Structural Plasticity of Cholesteryl Ester Transfer Protein Assists the Lipid Transfer Activity *

Journal of Biological Chemistry, 2016
Cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters (CEs) and triglycerides between different lipoproteins. Recent studies have shown that blocking the function of CETP can increase the level of HDL cholesterol in blood ...
Venkat R. Chirasani, Prasanna D. Revanasiddappa, S. Senapati   +2 more
semanticscholar   +1 more source

Rethinking Statin Dosage in Coronary Disease

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
It is widely acknowledged that a sufficient statin dose is important in the management of symptomatic coronary disease, along with weight reduction and appropriate antithrombotic, blood pressure, and diabetes pharmacotherapy. Mid‐range statin doses have been shown to achieve the maximum improvements in total mortality and have the advantage of greater ...
Simon B. Dimmitt, Hans G. Stampfer, Michael C. Kennedy, Jennifer H. Martin   +3 more
wiley   +1 more source

A Chemical Genetic Approach To The Study Of Cellular Transport [PDF]

, 2005
The focus of this thesis is the use of chemical genetics to study two different aspects of membrane biology, (a) the mechanisms underlying cellular lipid transport and (b) the intersection between endocytic and exocytic traffic.
Nieland, T.J.F.
core   +2 more sources

Human liposarcoma cell line, SW872, secretes cholesteryl ester transfer protein in response to cholesterol

Journal of Lipid Research, 1996
Cholesteryl ester transfer protein (CETP) mediates the exchange of phospholipids and neutral lipids between the plasma lipoproteins, and plays an important role in high density lipoprotein (HDL) metabolism.
M A Richardson, D T Berg, P A Johnston, D McClure, B W Grinnell   +4 more
doaj   +1 more source

Plasma proteome correlates of lipid and lipoprotein: biomarkers of metabolic diversity and inflammation in children of rural Nepal. [PDF]

, 2019
Proteins involved in lipoprotein metabolism can modulate cardiovascular health. While often measured to assess adult metabolic diseases, little is known about the proteomes of lipoproteins and their relation to metabolic dysregulation and underlying ...
Christian, Parul, Cole, Robert N, Eroglu, Abdulkerim, Groopman, John, Lee, Sun Eun, Schulze, Kerry, Stewart, Christine P, West, Keith P, Wu, Lee S-F, Yager, James D   +9 more
core  

Cholesteryl ester transfer protein inhibition is associated with reduced risk of Sjögren's syndrome. [PDF]

Rheumatology (Oxford), 2023
Zhao SS, Dyball S.
europepmc   +1 more source