Results 11 to 20 of about 898 (129)

Associations among serum insulin, calprotectin, and C-reactive protein concentrations in Miniature Schnauzers with idiopathic hyperlipidemia before and after feeding an ultra-low-fat diet. [PDF]

J Vet Intern Med, 2022
Abstract Background Miniature Schnauzers (MS) commonly have idiopathic hypertriglyceridemia (HTGL), which is associated with insulin resistance (IR) and a subclinical inflammatory phenotype. Objectives Determine the association between indicators of IR and inflammatory biomarkers in MS with and without HTGL and identify how indicators of IR are ...
Xenoulis PG, Heilmann RM, Stavroulaki EM, Riggers DS, Gneipel LJ, Suchodolski JS, Steiner JM.   +6 more
europepmc   +2 more sources

Primary biliary cholangitis presenting as acute ischemic stroke: A rare association. [PDF]

Clin Case Rep, 2020
Primary biliary cholangitis is associated with hyperlipidemia, but studies show that the condition does not increase cardiovascular risks. The case presents acute ischemic stroke with no underlying risk factors and subsequent new diagnosis of primary biliary cholangitis, which can suggest possible association between primary biliary cholangitis and ...
Park B, Islam S, Vemulapalli RC, Shreve ME.   +3 more
europepmc   +2 more sources

Monocyte to high‐density lipoprotein ratio predicts clinical outcomes after acute ischemic stroke or transient ischemic attack

CNS Neuroscience &Therapeutics, Volume 29, Issue 7, Page 1953-1964, July 2023., 2023
Higher monocyte to high‐density lipoprotein ratio was associated with a high risk of all‐cause death and poor functional outcome at 3 months and 1 year in patients with ischemic or TIA. Elevated MHR can independently predict all‐cause death and poor functional outcome in patients with ischemic stroke or TIA.
Qin Xu, Qiong Wu, Lu Chen, Hao Li, Xue Tian, Xue Xia, Yijun Zhang, Xiaoli Zhang, Yongzhong Lin, Yiping Wu, Yongjun Wang, Xia Meng, Anxin Wang   +12 more
wiley   +1 more source

Endothelial‐protective effects of a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 agonist, SAR247799, in type‐2 diabetes rats and a randomized placebo‐controlled patient trial

British Journal of Clinical Pharmacology, Volume 87, Issue 5, Page 2303-2320, May 2021., 2021
Aims SAR247799 is a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 (S1P1) agonist designed to activate endothelial S1P1 and provide endothelial‐protective properties, while limiting S1P1 desensitization and consequent lymphocyte‐count reduction associated with higher doses.
Luc Bergougnan, Grit Andersen, Leona Plum‐Mörschel, Maria Francesca Evaristi, Bruno Poirier, Agnes Tardat, Marcel Ermer, Theresa Herbrand, Jorge Arrubla, Hans Veit Coester, Roberto Sansone, Christian Heiss, Olivier Vitse, Fabrice Hurbin, Rania Boiron, Xavier Benain, David Radzik, Philip Janiak, Anthony J. Muslin, Lionel Hovsepian, Stephane Kirkesseli, Paul Deutsch, Ashfaq A. Parkar   +22 more
wiley   +1 more source

Lipoprotein(a) the Insurgent: A New Insight into the Structure, Function, Metabolism, Pathogenicity, and Medications Affecting Lipoprotein(a) Molecule

Journal of Lipids, Volume 2020, Issue 1, 2020., 2020
Lipoprotein(a) [Lp(a)], aka “Lp little a”, was discovered in the 1960s in the lab of the Norwegian physician Kåre Berg. Since then, we have greatly improved our knowledge of lipids and cardiovascular disease (CVD). Lp(a) is an enigmatic class of lipoprotein that is exclusively formed in the liver and comprises two main components, a single copy of ...
Motasim M. Jawi, Jiri Frohlich, Sammy Y. Chan, Xian-Cheng Jiang   +3 more
wiley   +1 more source

Oral Protein Therapy for the Future - Transport of Glycolipid-Modified Proteins: Vision or Fiction? [PDF]

, 2010
The reliable and early diagnosis of common complex multifactorial diseases depends on the individual determination of all (or as many as possible) polymorphisms of each susceptibility gene together with amount and type of the corresponding gene products ...
Mueller, Guenter
core   +1 more source

Large-scale gene-centric analysis identifies novel variants for coronary artery disease [PDF]

, 2011
Coronary artery disease (CAD) has a significant genetic contribution that is incompletely characterized. To complement genome-wide association (GWA) studies, we conducted a large and systematic candidate gene study of CAD susceptibility, including ...
Strawbridge, Rona, The IBC 50K CAD Consortium,   +1 more
core   +1 more source

Consumption of Artificially-Sweetened Soft Drinks in Pregnancy and Risk of Child Asthma and Allergic Rhinitis [PDF]

, 2013
Background: Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. Objective: To examine relation of intake of artificially-sweetened beverages during pregnancy with child ...
Halldorsson, Thorhallur I., Maslova, Ekaterina, Olsen, Sjurdur F., Strøm, Marin   +3 more
core   +7 more sources

Description of Prototype Modes-of-Action Related to Repeated Dose Toxicity [PDF]

, 2012
This report presents the definition and detailed documentation of chosen toxicological MoAs associated with repeated dose target organ toxicity as a first step in building a "prototype" safety assessment framework.
GOUMENOU MARINA - PARESKEVI, LANDESMANN Brigitte, MUNN SHARON, WHELAN Maurice   +3 more
core   +1 more source

Preventive Effect of Naringin on Metabolic Syndrome and Its Mechanism of Action: A Systematic Review

Evidence-Based Complementary and Alternative Medicine, Volume 2019, Issue 1, 2019., 2019
Background. Metabolic syndrome (MetS), which consists of cluster of conditions, hypertension, hyperlipidemia, hyperglycemia, and visceral obesity, is affecting population worldwide. Studies have shown that plant derived flavonoids have the ability to alleviate MetS.
Sivanesan Raja Kumar, Elvy Suhana Mohd Ramli, Nurul Alimah Abdul Nasir, Nafeeza Hj Mohd Ismail, Nur Azlina Mohd Fahami, Fatima Martel   +5 more
wiley   +1 more source