Results 11 to 20 of about 266,324 (188)

The secondary structure of apolipoprotein A-I on 9.6-nm reconstituted high-density lipoprotein determined by EPR spectroscopy. [PDF]

The FEBS Journal, Volume 280, Issue 14, Page 3416-3424, July 2013., 2013
Apolipoprotein A-I (ApoA-I) is the major protein component of high-density lipoprotein (HDL), and is critical for maintenance of cholesterol homeostasis.
Borja, Mark S, Budamagunta, Madhu S, Lagerstedt, Jens O, Oda, Michael N, Petrlova, Jitka, Voss, John C   +5 more
core   +2 more sources

Associations among serum insulin, calprotectin, and C-reactive protein concentrations in Miniature Schnauzers with idiopathic hyperlipidemia before and after feeding an ultra-low-fat diet. [PDF]

J Vet Intern Med, 2022
Abstract Background Miniature Schnauzers (MS) commonly have idiopathic hypertriglyceridemia (HTGL), which is associated with insulin resistance (IR) and a subclinical inflammatory phenotype. Objectives Determine the association between indicators of IR and inflammatory biomarkers in MS with and without HTGL and identify how indicators of IR are ...
Xenoulis PG, Heilmann RM, Stavroulaki EM, Riggers DS, Gneipel LJ, Suchodolski JS, Steiner JM.   +6 more
europepmc   +2 more sources

Monocyte to high-density lipoprotein ratio predicts clinical outcomes after acute ischemic stroke or transient ischemic attack. [PDF]

CNS Neurosci Ther, 2023
Higher monocyte to high‐density lipoprotein ratio was associated with a high risk of all‐cause death and poor functional outcome at 3 months and 1 year in patients with ischemic or TIA. Elevated MHR can independently predict all‐cause death and poor functional outcome in patients with ischemic stroke or TIA.
Xu Q, Wu Q, Chen L, Li H, Tian X, Xia X, Zhang Y, Zhang X, Lin Y, Wu Y, Wang Y, Meng X, Wang A.   +12 more
europepmc   +2 more sources

Primary biliary cholangitis presenting as acute ischemic stroke: A rare association. [PDF]

Clin Case Rep, 2020
Primary biliary cholangitis is associated with hyperlipidemia, but studies show that the condition does not increase cardiovascular risks. The case presents acute ischemic stroke with no underlying risk factors and subsequent new diagnosis of primary biliary cholangitis, which can suggest possible association between primary biliary cholangitis and ...
Park B, Islam S, Vemulapalli RC, Shreve ME.   +3 more
europepmc   +2 more sources

Obicetrapib-the Rebirth of CETP Inhibitors? [PDF]

Curr Atheroscler Rep
Purpose of Review To provide perspective on the current development status, and potential future role, of obicetrapib, a third-generation cholesterylester transfer protein (CETP) inhibitor.
Chang B, Laffin LJ, Sarraju A, Nissen SE.   +3 more
europepmc   +2 more sources

Endothelial-protective effects of a G-protein-biased sphingosine-1 phosphate receptor-1 agonist, SAR247799, in type-2 diabetes rats and a randomized placebo-controlled patient trial. [PDF]

Br J Clin Pharmacol, 2021
Aims SAR247799 is a G‐protein‐biased sphingosine‐1 phosphate receptor‐1 (S1P1) agonist designed to activate endothelial S1P1 and provide endothelial‐protective properties, while limiting S1P1 desensitization and consequent lymphocyte‐count reduction associated with higher doses.
Bergougnan L, Andersen G, Plum-Mörschel L, Evaristi MF, Poirier B, Tardat A, Ermer M, Herbrand T, Arrubla J, Coester HV, Sansone R, Heiss C, Vitse O, Hurbin F, Boiron R, Benain X, Radzik D, Janiak P, Muslin AJ, Hovsepian L, Kirkesseli S, Deutsch P, Parkar AA.   +22 more
europepmc   +2 more sources

Apolipoprotein C1: Its Pleiotropic Effects in Lipid Metabolism and Beyond. [PDF]

Int J Mol Sci, 2019
Apolipoprotein C1 (apoC1), the smallest of all apolipoproteins, participates in lipid transport and metabolism. In humans, APOC1 gene is in linkage disequilibrium with APOE gene on chromosome 19, a proximity that spurred its investigation. Apolipoprotein
Fuior EV, Gafencu AV.
europepmc   +2 more sources

Lipid transfer to HDL, CETP and HDL composition in coronary artery disease patients with or without type 2 diabetes mellitus

European Journal of Preventive Cardiology, 2020
Patients with coronary artery disease (CAD) and type 2 diabetes mellitus (T2DM) are supposedly exposed to greater risk of major adverse cardiovascular events, which highlights the importance of secondary prevention in the CADþT2DM population. Comparisons
T. Tavoni, M. C. Sprandel, O. G. Laverdy, C. Strunz, J. Ramires, R. Kalil‐Filho, W. Hueb, R. Maranhão   +7 more
semanticscholar   +1 more source

A Miniaturized Extruder to Prototype Amorphous Solid Dispersions: Selection of Plasticizers for Hot Melt Extrusion. [PDF]

Pharmaceutics, 2018
Hot-melt extrusion is an option to fabricate amorphous solid dispersions and to enhance oral bioavailability of poorly soluble compounds. The selection of suitable polymer carriers and processing aids determines the dissolution, homogeneity and stability
Lauer ME, Maurer R, Paepe AT, Stillhart C, Jacob L, James R, Kojima Y, Rietmann R, Kissling T, van den Ende JA, Schwarz S, Grassmann O, Page S.   +12 more
europepmc   +2 more sources

Lipoprotein(a) the Insurgent: A New Insight into the Structure, Function, Metabolism, Pathogenicity, and Medications Affecting Lipoprotein(a) Molecule

Journal of Lipids, Volume 2020, Issue 1, 2020., 2020
Lipoprotein(a) [Lp(a)], aka “Lp little a”, was discovered in the 1960s in the lab of the Norwegian physician Kåre Berg. Since then, we have greatly improved our knowledge of lipids and cardiovascular disease (CVD). Lp(a) is an enigmatic class of lipoprotein that is exclusively formed in the liver and comprises two main components, a single copy of ...
Motasim M. Jawi, Jiri Frohlich, Sammy Y. Chan, Xian-Cheng Jiang   +3 more
wiley   +1 more source