Description of Prototype Modes-of-Action Related to Repeated Dose Toxicity [PDF]
, 2012 This report presents the definition and detailed documentation of chosen toxicological MoAs associated with repeated dose target organ toxicity as a first step in building a "prototype" safety assessment framework.
GOUMENOU MARINA - PARESKEVI +3 more
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Significance of long chain polyunsaturated fatty acids in human health
Clinical and Translational Medicine, Volume 6, Issue 1, December 2017., 2017 AbstractIn the last decades, the development of new technologies applied to lipidomics has revitalized the analysis of lipid profile alterations and the understanding of the underlying molecular mechanisms of lipid metabolism, together with their involvement in the occurrence of human disease.
Rafael Zárate +4 more
wiley +1 more source
Influência de componentes dos alimentos no metabolismo lipídico: cenários e perspectiva no controle e prevenção de dislipidemias [PDF]
, 2010 Cardiovascular diseases (CVD) are the main causes of death in the Western world. Among the risk factors that are modifiable by diet, for reducing cardiovascular disease risks, the total plasma concentrations of cholesterol, triglycerides, LDL-C, and HDL ...
ARÊAS, José Alfredo Gomes +2 more
core +3 more sources
Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117 411 patients [PDF]
, 2014 Objective To investigate the effects on cardiovascular outcomes of drug interventions that increase high density lipoprotein levels. Design Meta-analysis.
Francis, DP +3 more
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BioMed Research International, Volume 2013, Issue 1, 2013., 2013 The fruit pulp extract of Tamarindus indica has been reported for its antioxidant and hypolipidemic properties. In this study, the methanol extract of T. indica fruit pulp was investigated for its effects on the abundance of HepG2 cell lysate proteins. Cell lysate was extracted from HepG2 cells grown in the absence and presence of the methanol extract ...
Ursula R. W. Chong +5 more
wiley +1 more source
Effect of dietary elaidic versus vaccenic acid on blood and liver lipids in the hamster [PDF]
, 2001 Male hamsters (30 per group) were fed five different semi-purified diets ad libitum. The diets, containing 30% of energy (en%) as fat, differed in their dietary fat composition (specified fatty acids exchanged at 10 en%) and were fed for 4 weeks.
Berkel, Th.J.C. (Theo) van +3 more
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Journal of Lipids, Volume 2012, Issue 1, 2012., 2012 Non‐alcoholic fatty liver disease (NAFLD) is currently evolving as the most common liver disease worldwide. It may progress to liver cirrhosis and liver cancer and is poised to represent the most common indication for liver transplantation in the near future.
Michael Fuchs, Piero Portincasa
wiley +1 more source
A New N-terminal Recognition Domain in Caveolin-1 Interacts with Sterol Carrier Protein-2 (SCP-2) [PDF]
, 2007 Although plasma membrane domains, such as caveolae, provide an organizing principle for signaling pathways and cholesterol homeostasis in the cell, relatively little is known regarding specific mechanisms, whereby intracellular lipid-binding proteins are
Ball, Judith M. +7 more
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The companion dog as a model for human aging and mortality [PDF]
, 2018 Around the world, human populations have experienced large increases in average lifespan over the last 150 years, and while individuals are living longer, they are spending more years of life with multiple chronic morbidities.
Agur +47 more
core +2 more sources
Assignment of the binding site for Haptoglobin on Apolipoprotein A-I [PDF]
, 2004 Haptoglobin (Hpt) was previously found binding the high-density lipoprotein (HDL) Apolipoprotein A-I (ApoA-I) and able to inhibit the ApoA-I-dependent activity of the enzyme Lecithin:Cholesterol Acyl-Transferase (LCAT), which plays a major role in the ...
ABRESCIA, PAOLO +4 more
core +1 more source