Results 51 to 60 of about 266,324 (188)
Exact Solution of the Munoz-Eaton Model for Protein Folding [PDF]
Phys. Rev. Lett. 88 (25), 258101 (2002), 2002 A transfer-matrix formalism is introduced to evaluate exactly the partition function of the Munoz-Eaton model, relating the folding kinetics of proteins of known structure to their thermodynamics and topology. This technique can be used for a generic protein, for any choice of the energy and entropy parameters, and in principle allows the model to be ...
arxiv +1 more source
The red blood cell as a mediator of endothelial dysfunction in patients with familial hypercholesterolemia and dyslipidemia [PDF]
, 2023 Peer ...
Brinck, Jonas +13 more
core +1 more source
The crystal structure of human microsomal triglyceride transfer protein
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance This study provides a structure for microsomal triglyceride transfer protein, a key protein in lipid metabolism and transport. Microsomal triglyceride transfer protein is linked to a human disease state, abetalipoproteinemia.
E. Biterova +7 more
semanticscholar +1 more source
Journal of Lipid Research, 2017 Disturbance in lipid metabolism has been suggested as a major pathogenic factor for age-related macular degeneration (AMD). Conventional lipid measures have been inconsistently associated with AMD.
Chui Ming Gemmy Cheung +10 more
doaj
Density Functional Theory for Protein Transfer Free Energy [PDF]
, 2013 We cast the problem of protein transfer free energy within the formalism of density functional theory (DFT), treating the protein as a source of external potential that acts upon the solvent. Solvent excluded volume, solvent-accessible surface area, and temperature-dependence of the transfer free energy all emerge naturally within this formalism, and ...
arxiv +1 more source
Quantitative Imaging of Protein-Protein Interactions by Multiphoton Fluorescence Lifetime Imaging Microscopy using a Streak camera [PDF]
Journal of Biomedical Optics Vo.8, 362 (July 2003), 2003 Fluorescence Lifetime Imaging Microscopy (FLIM) using multiphoton excitation techniques is now finding an important place in quantitative imaging of protein-protein interactions and intracellular physiology. We review here the recent developments in multiphoton FLIM methods and also present a description of a novel multiphoton FLIM system using a ...
arxiv +1 more source
Cholesterol efflux pathways, inflammation, and atherosclerosis [PDF]
, 2021 Plasma levels of high-density lipoprotein (HDL) inversely correlate with the incidence of cardiovascular diseases (CVD). The causal relationship between plasma HDL-cholesterol levels and CVD has been called into question by Mendelian randomization ...
Groenen, Anouk G. +3 more
core +1 more source
High-density lipoproteins: a novel therapeutic target for cardiovascular disease
, 2011 Cardiovascular disease has a high rate of mortality in both Western and developing countries. Atherosclerosis and generation of reactive oxygen species through oxidative stress is the major risk factor for cardiovascular disease.
T. Saleem, P. Rani, K. Gauthaman
semanticscholar +1 more source
Chemically Transferable Generative Backmapping of Coarse-Grained Proteins [PDF]
arXiv, 2023 Coarse-graining (CG) accelerates molecular simulations of protein dynamics by simulating sets of atoms as singular beads. Backmapping is the opposite operation of bringing lost atomistic details back from the CG representation. While machine learning (ML) has produced accurate and efficient CG simulations of proteins, fast and reliable backmapping ...
arxiv
Atg2: A novel phospholipid transfer protein that mediates de novo autophagosome biogenesis
Protein Science, 2019 The degradation of cytoplasmic components via autophagy is crucial for intracellular homeostasis. In the process of autophagy, a newly synthesized isolation membrane (IM) is developed to sequester degradation targets and eventually the IM seals, forming ...
T. Osawa, N. Noda
semanticscholar +1 more source