Results 21 to 30 of about 1,423 (95)

Folic Acid Supplementation Attenuates Hepatic Steatosis by Enhancing Choline Availability and Remodeling Fatty Acid Profiles in Mice Fed a High-Fat Diet. [PDF]

FASEB Bioadv
Folic acid supplementation to high‐fat diets reduced hepatic steatosis in male C57BL/6J mice, as evidenced by lower triacylglycerol (TAG) levels in the liver. These effects were associated with increased hepatic choline availability, upregulation of choline‐metabolizing genes, and alterations in the hepatic fatty acid profile, suggestive of suppressed ...
Kranenburg E, Kubant R, Yang Z, Metherel AH, Chen CT, Beaudry JL, Cho CE, Vaz P, Anderson GH.   +8 more
europepmc   +2 more sources

Phospholipid Interconversion and Transport Are Altered in Glaucoma. [PDF]

FASEB J
Decreased phosphatidylserine (PS) and increased phosphatidylethanolamine (PE) occur in both trabecular meshwork (TM) cells and aqueous humor due to aberrant phosphatidylserine decarboxylase (PSD) over‐expression, and variation in levels of individual PS or PE species differing by only a few acyl chains occurs due to impaired lipid transport due to ...
Edwards G, Kaur R, Mueller A, Ziebarth N, Lee RK, Bhattacharya SK.   +5 more
europepmc   +2 more sources

Enzalutamide-Resistant STEAP4⁺ MyoCAF Secrete Phosphatidylcholine to Foster Progression by Activating Stemness in Hormone-Sensitive Prostate Cancer. [PDF]

Adv Sci (Weinh)
Expanding enzalutamide (ENZ) use in hormone‐sensitive prostate cancer (HSPC) faces resistance. Single‐cell profiling identifies therapy‐resistant STEAP4+ myofibroblastic cancer‐associated fibroblast (SETAP4+ myoCAF). These myoCAFs drive resistance via TFE3‐mediated autophagy and PCYT1A‐led phosphatidylcholine overproduction, creating a phospholipid ...
Wang W, Zhao J, Li T, Fan G, Zhang J, Zheng C, Xie Z, Zhang Y, Feng C, Cao T, Li J, Ju G, Cui D, Xia S, Han B.   +14 more
europepmc   +2 more sources

Glycerophospholipids: Roles in Cell Trafficking and Associated Inborn Errors. [PDF]

J Inherit Metab Dis
ABSTRACT Glycerophospholipids (GPLs) are the main lipid components of cellular membranes. They are implicated in membrane structure, vesicle trafficking, neurotransmission, and cell signalling. GPL molecules are amphiphilic, organized around the three carbons of glycerol. Positions sn‐1 and sn‐2 are each esterified to a fatty acid (FA).
Lamari F, Rossignol F, Mitchell GA.
europepmc   +2 more sources

Rumen-protected choline and methionine during the periparturient period affect choline metabolites, amino acids, and hepatic expression of genes associated with one-carbon and lipid metabolism

Journal of Dairy Science, 2023
: Feeding supplemental choline and Met during the periparturient period can have positive effects on cow performance; however, the mechanisms by which these nutrients affect performance and metabolism are unclear.
S.B. Potts, K.M. Brady, C.M. Scholte, K.M. Moyes, N.E. Sunny, R.A. Erdman   +5 more
doaj   +1 more source

Phosphatidylcholine alteration identified using MALDI imaging MS in HBV-infected mouse livers and virus-mediated regeneration defects. [PDF]

PLoS ONE, 2014
In this study, we investigated whether hepatitis B virus (HBV) causes the alteration of lipid metabolism and composition during acute infection and liver regeneration in a mouse model.
Eun-Sook Park, Jeong Hwa Lee, Ji Hye Hong, Yong Kwang Park, Joon Won Lee, Won-Jae Lee, Jae Won Lee, Kwang Pyo Kim, Kyun-Hwan Kim   +8 more
doaj   +1 more source

Literature-Based Discovery to Elucidate the Biological Links between Resistant Hypertension and COVID-19

Biology, 2023
Multiple studies have reported new or exacerbated persistent or resistant hypertension in patients previously infected with COVID-19. We used literature-based discovery to identify and prioritize multi-scalar explanatory biology that relates resistant ...
David Kartchner, Kevin McCoy, Janhvi Dubey, Dongyu Zhang, Kevin Zheng, Rushda Umrani, James J. Kim, Cassie S. Mitchell   +7 more
doaj   +1 more source

Ethanolaminephosphate cytidylyltransferase is essential for survival, lipid homeostasis and stress tolerance in Leishmania major.

PLoS Pathogens, 2023
Glycerophospholipids including phosphatidylethanolamine (PE) and phosphatidylcholine (PC) are vital components of biological membranes. Trypanosomatid parasites of the genus Leishmania can acquire PE and PC via de novo synthesis and the uptake/remodeling
Somrita Basu, Mattie C Pawlowic, Fong-Fu Hsu, Geoff Thomas, Kai Zhang   +4 more
doaj   +1 more source

Phosphatidic acid phosphatase LPIN1 in phospholipid metabolism and stemness in hematopoiesis and AML. [PDF]

Hemasphere
Abstract Targeting metabolism represents a promising approach to eradicate leukemic stem cells (LSCs) that are considered critical drivers of relapse in acute myeloid leukemia (AML). In this study, we demonstrate that the phosphatidic acid phosphatase LPIN1, which regulates the synthesis of diacylglycerol, the key substrate for triacylglycerol, and ...
Huber K, Garg S, Schlautmann L, Wang R, He L, Huth R, Pouya A, Rohde C, Janssen M, Lüchtenborg C, Arnold C, Luque-Navarro PM, Zaugg JB, Raffel S, Müller-Tidow C, Jeremias I, López-Cara LC, Brügger B, Pabst C.   +18 more
europepmc   +2 more sources

Sequencing and characterization of Helcococcus ovis: a comprehensive comparative genomic analysis of virulence

BMC Genomics, 2023
Background Helcococcus ovis (H. ovis) is an emerging bacterial pathogen that commonly causes opportunistic respiratory, mammary, and uterine infections across mammalian hosts.
Federico Cunha, Segundo Casaro, Kristi L. Jones, Rafael S. Bisinotto, Subhashinie Kariyawasam, Mary B. Brown, Klibs N. Galvão   +6 more
doaj   +1 more source