Results 1 to 10 of about 1,773 (158)
Mechanism of Mg2+-Accompanied Product Release in Sugar Nucleotidyltransferases [PDF]
Structure, 2018 The nucleotidyl transfer reaction, catalyzed by sugar nucleotidyltransferases (SNTs), is assisted by two active site Mg2+ ions. While studying this reaction using X-ray crystallography, we captured snapshots of the pyrophosphate (product) as it exits along a pocket.
Balaji Prakash +2 more
exaly +8 more sources
Molecular mechanisms of template-independent RNA polymerization by tRNA nucleotidyltransferases [PDF]
Frontiers in Genetics, 2014 The universal 3'-terminal CCA sequence of tRNA is built and/or synthesized by the CCA-adding enzyme, CTP:(ATP) tRNA nucleotidyltransferase. This RNA polymerase has no nucleic acid template, but faithfully synthesizes the defined CCA sequence on the 3 ...
Seisuke Yamashita, Kozo Tomita
exaly +5 more sources
ant(6)-I Genes Encoding Aminoglycoside O-Nucleotidyltransferases Are Widely Spread Among Streptomycin Resistant Strains of Campylobacter jejuni and Campylobacter coli [PDF]
Frontiers in Microbiology, 2018 Thermotolerant Campylobacter species C. jejuni and C. coli are actually recognized as the major bacterial agent responsible for food-transmitted gastroenteritis. The most effective antimicrobials against Campylobacter are macrolides and some, but not all
Alberto Quesada +2 more
exaly +5 more sources
Nature Communications, 2023 Purine-containing nucleotide second messengers regulate diverse cellular activities. Cyclic di-pyrimidines mediate anti-phage functions in bacteria; however, the synthesis mechanism remains elusive.
Chia-Shin Yang +5 more
doaj +3 more sources
Journal of the American Chemical Society, 2023 Bacterial glycomes are rich in prokaryote-specific or “rare” sugars that are absent in mammals. Like common sugars found across organisms, rare sugars are typically activated as nucleoside diphosphate sugars (NDP-sugars) by nucleotidyltransferases.
Tania Lupoli, Meng Zheng, Hanee Kim
exaly +3 more sources
Identification and Characterization of Mammalian Mitochondrial tRNA nucleotidyltransferases [PDF]
Journal of Biological Chemistry, 2001 The CCA-adding enzyme (ATP:tRNA adenylyltransferase or CTP:tRNA cytidylyltransferase (EC 2.7.7.25)) generates the conserved CCA sequence responsible for the attachment of amino acid at the 3′ terminus of tRNA molecules.
Yukihide Tomari +2 more
exaly +4 more sources
PLoS Genetics, 2017 The emergence and spread of antibiotic resistance among Acinetobacter spp. have been investigated extensively. Most studies focused on the multiple antibiotic resistance genes located on plasmids or genomic resistance islands.
Gang Zhang +7 more
doaj +2 more sources
The terminal nucleotidyltransferases of calf thymus nuclei.
Journal of Biological Chemistry, 1966 An enzyme from calf thymus nuclei which incorporates ribonucleotides or deoxyribonucleotides into terminal positions of deoxyribonucleic acid has been purified and its mechanism of action elucidated.
M. Gottesman, E. Canellakis
semanticscholar +3 more sources
Journal of Biological Chemistry, 1988 Resistance to lincomycin by inactivation has been detected in numerous clinical isolates of Staphylococcus; in crude extracts of Staphylococcus haemolyticus BM4610 and Staphylococcus aureus BM4611, inactivation of lincomycin and clindamycin requires the ...
P Courvalin
exaly +2 more sources
Structures and mechanism of E2‐CBASS anti‐phage system
mLifeBacteria deploy diverse innate immune systems to combat bacteriophage infections. The cyclic‐oligonucleotide‐based anti‐phage signaling system (CBASS) is a type of innate prokaryotic immune system.
Jun Xiao +7 more
doaj +2 more sources