Results 31 to 40 of about 7,865 (199)

MINTmap: fast and exhaustive profiling of nuclear and mitochondrial tRNA fragments from short RNA-seq data. [PDF]

, 2017
Transfer RNA fragments (tRFs) are an established class of constitutive regulatory molecules that arise from precursor and mature tRNAs. RNA deep sequencing (RNA-seq) has greatly facilitated the study of tRFs.
Loher, Phillipe, Rigoutsos, Isidore, Telonis, Aristeidis G.   +2 more
core   +2 more sources

NF45 dimerizes with NF90, Zfr and SPNR via a conserved domain that has a nucleotidyltransferase fold [PDF]

, 2012
Nuclear factors NF90 and NF45 form a complex involved in a variety of cellular processes and are thought to affect gene expression both at the transcriptional and translational level.
Adams, Atlanta G. Cook, Barber, Bricogne, Chen, Collaborative computing project, n, Corthesy, Cowtan, Deng, Diebold, Duchange, Emsley, Fukuda, Gomila, Guan, Holm, Hoque, Isken, Isken, Isken, Kabsch, Kao, Kraft, Kuwano, Kuwano, Liao, Lo Conte, Marcoulatos, McCoy, Neplioueva, Orford, Parker, Parrott, Reichman, Sakamoto, Scarlett, Shamanna, Sheldrick, Shi, Shi, Shim, Stagno, Urszula M. Wolkowicz, Worringer, Xu, Yue, Zeqiraj, Zhao   +47 more
core   +1 more source

Structural and Molecular Basis for Resistance to Aminoglycoside Antibiotics by the Adenylyltransferase ANT(2″)-Ia

mBio, 2015
The aminoglycosides are highly effective broad-spectrum antimicrobial agents. However, their efficacy is diminished due to enzyme-mediated covalent modification, which reduces affinity of the drug for the target ribosome.
Georgina Cox, Peter J. Stogios, Alexei Savchenko, Gerard D. Wright   +3 more
doaj   +1 more source

Biophysical and enzymatic properties of aminoglycoside adenylyltransferase AadA6 from Pseudomonas aeruginosa [PDF]

, 2015
The gene coding for the aminoglycoside adenylyltransferase (aadA6) from a clinical isolate of Pseudomonas aeruginosa was cloned and expressed in Escherichia coli strain BL21(DE3)pLysS.
Akdemir, G., Allaart, C.F., Berg, R. van den, Bergstra, S.A., Han, K.H., Kerstens, P.J.S.M., Landewe, R.B.M., Lems, W.F., Markusse, I.M., Ronday, H.K.   +9 more
core   +2 more sources

Characterization of wild and captive baboon gut microbiota and their antibiotic resistomes [PDF]

, 2018
Antibiotic exposure results in acute and persistent shifts in the composition and function of microbial communities associated with vertebrate hosts.
Boolchandani, Manish, Chiou, Kenneth L, Dantas, Gautam, Gibson, Molly K, Jolly, Clifford J, Patel, Sanket, Pehrsson, Erica C, Phillips-Conroy, Jane E, Rogers, Jeffrey, Tsukayama, Pablo   +9 more
core   +2 more sources

Physicochemical analysis of rotavirus segment 11 supports a 'modified panhandle' structure and not the predicted alternative tRNA-like structure (TRLS) [PDF]

, 2013
.Rotaviruses are a major cause of acute gastroenteritis, which is often fatal in infants. The viral genome consists of 11 double-stranded RNA segments, but little is known about their cis-acting sequences and structural elements.
A Heerschap, A L’Hernault, A Wilm, AE Simon, Andrew M. Lever, AR Gruber, BI Klasens, D Chen, D Chen, D Yue, D Yue, E Madore, E Matsuo, EC Hutchinson, Emily Manktelow, EV Puglisi, H Heus, HD Cho, J Jia, JC Kenyon, Jonathan Lever, JR Gog, JT Patton, Laura E. Easton, LE Easton, M Barro, M Estes, MA Tortorici, MW Friederich, N Figueroa, P Annamalai, Peter J. Lukavsky, PJ Lukavsky, R Giegé, R Giegé, RC Olsthoorn, S Nishimura, SC Chen, SH Bernhart, Subhajit Biswas, T Nagaike, TW Dreher, TW Dreher, TW Dreher, TW Dreher, Ulrich Desselberger, W Li, Wilson Li   +47 more
core   +1 more source

In Silico Assigned Resistance Genes Confer Bifidobacterium with Partial Resistance to Aminoglycosides but Not to Β-Lactams [PDF]

, 2013
peer-reviewedBifidobacteria have received significant attention due to their contribution to human gut health and the use of specific strains as probiotics.
Cotter, Paul D., Fitzgerald, Gerald F, Fouhy, Fiona, O'Connell-Motherway, Mary, Ross, R Paul, STANTON, CATHERINE, van Sinderen, Douwe   +6 more
core   +3 more sources

Relating the metatranscriptome and metagenome of the human gut [PDF]

, 2014
Although the composition of the human microbiome is now wellstudied, the microbiota’s \u3e8 million genes and their regulation remain largely uncharacterized.
Boylan, Matthew R., Chan, Andrew T., Ciulla, Dawn, Earl, Ashlee M., Franzosa, Eric A., Garrett, Wendy S., Gevers, Dirk, Giannoukos, Georgia, Huttenhower, Curtis, Izard, Jacques, Morgan, Xochitl C., Reyes, Joshua, Segata, Nicola, Waldron, Levi   +13 more
core   +2 more sources

Purification and Characterization of a Mutant tRNA Nucleotidyltransferase [PDF]

European Journal of Biochemistry, 1980
tRNA nucleotidyltransferase has been extensively purified from a mutant strain of Escherichia coli which displays greatly decreased AMP incorporation, but normal CMP incorporation. The defect in AMP incorporation is retained throughout the purification of the mutant protein. The mutant protein behaves identically to the wild‐type protein with regard to
R G, McGann, M P, Deutscher
openaire   +2 more sources

Manipulation of mitochondrial poly(A) polymerase family proteins in Trypanosoma brucei impacts mRNA termini processing

Frontiers in Parasitology
RNA-specific nucleotidyltransferases (rNTrs) add nontemplated nucleotides to the 3′ end of RNA. Two noncanonical rNTRs that are thought to be poly(A) polymerases (PAPs) have been identified in the mitochondria of trypanosomes – KPAP1 and KPAP2.
Clara M. Smoniewski, Poorya Mirzavand Borujeni, Marshall Hampton, Austin Petersen, Sean P. Faacks, Reza Salavati, Sara L. Zimmer   +6 more
doaj   +1 more source