Results 11 to 20 of about 1,773 (158)

tRNA‐nucleotidyltransferases: Highly unusual RNA polymerases with vital functions [PDF]

FEBS Letters, 2010
tRNA-nucleotidyltransferases are fascinating and unusual RNA polymerases responsible for the synthesis of the nucleotide triplet CCA at the 3′-terminus of tRNAs.
Mario Mörl
exaly   +3 more sources

Functions and mechanisms of RNA tailing by metazoan terminal nucleotidyltransferases

Wiley Interdisciplinary Reviews - RNA, 2020
Termini often determine the fate of RNA molecules. In recent years, 3′ ends of almost all classes of RNA species have been shown to acquire nontemplated nucleotides that are added by terminal nucleotidyltransferases (TENTs). The best‐described role of 3′
Vladyslava Liudkovska, A. Dziembowski
semanticscholar   +2 more sources

A Eubacterial Origin for the Human tRNA Nucleotidyltransferase? [PDF]

Biological Chemistry, 2001
tRNA CCA-termini are generated and maintained by tRNA nucleotidyltransferases. Together with poly(A) polymerases and other enzymes they belong to the nucleotidyltransferase superfamily. However, sequence alignments within this family do not allow to distinguish between CCA-adding enzymes and poly(A) polymerases. Furthermore, due to the lack of sequence
Reichert, A. S., Thurlow, D. L., Mörl, M.   +2 more
openaire   +6 more sources

Biochemical and structural bioinformatics studies of fungal CutA nucleotidyltransferases explain their unusual specificity toward CTP and increased tendency for cytidine incorporation at the 3′-terminal positions of synthesized tails

RNA: A publication of the RNA Society, 2017
Noncanonical RNA nucleotidyltransferases (NTases), including poly(A), poly(U) polymerases (PAPs/PUPs), and C/U-adding enzymes, modify 3′-ends of different transcripts affecting their functionality and stability.
K. Kobyłecki, K. Kuchta, A. Dziembowski, K. Ginalski, R. Tomecki   +4 more
semanticscholar   +2 more sources

The complete genome sequence of hyperthermophile Dictyoglomus turgidum DSM 6724™ reveals a specialized carbohydrate fermentor

Frontiers in Microbiology, 2016
Here we report the complete genome sequence of the chemoorganotrophic, extremely thermophilic bacterium, Dictyoglomus turgidum, which is a Gram negative, strictly anaerobic bacterium. D. turgidum and D.
Phillip Brumm, Phillip Brumm, David A Mead, David A Mead, Krishna Gowda, Krishna Gowda, Frank T Robb   +6 more
doaj   +2 more sources

A Phylogeny of Bacterial RNA Nucleotidyltransferases: Bacillus halodurans Contains Two tRNA Nucleotidyltransferases

Journal of Bacteriology, 2005
George Jones, Patricia Bralley
exaly   +2 more sources

Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins [PDF]

Nature Communications
Nucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance.
Tom J. Arrowsmith, Xibing Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower   +8 more
doaj   +2 more sources

Evolution of tRNA nucleotidyltransferases: A small deletion generated CC-adding enzymes

Proceedings of the National Academy of Sciences of the United States of America, 2008
Heike Betat, Mario Mörl
exaly   +2 more sources

Substrate Affinity Versus Catalytic Efficiency: Ancestral Sequence Reconstruction of tRNA Nucleotidyltransferases Solves an Enzyme Puzzle

Molecular biology and evolution, 2022
In tRNA maturation, CCA-addition by tRNA nucleotidyltransferase is a unique and highly accurate reaction. While the mechanism of nucleotide selection and polymerization is well understood, it remains a mystery why bacterial and eukaryotic enzymes exhibit
M. Hager, Marie-Theres Pöhler, Franziska Reinhardt, Karolin Wellner, Jessica Hübner, H. Betat, S. Prohaska, Mario Mörl   +7 more
semanticscholar   +1 more source

Infancy‐onset diabetes caused by de‐regulated AMPylation of the human endoplasmic reticulum chaperone BiP

EMBO Molecular Medicine, 2023
Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell loss and diabetes mellitus. Here we report on five individuals from three different consanguineous families with infancy‐onset diabetes mellitus and severe ...
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco   +9 more
doaj   +1 more source