Results 41 to 50 of about 6,924 (153)

Thermodynamics of binding of divalent magnesium and manganese to uridine phosphates: implications for diabetes-related hypomagnesaemia and carbohydrate biocatalysis

Chemistry Central Journal, 2008
Background Although the necessity of divalent magnesium and manganese for full activity of sugar nucleotidyltransferases and glycosyltransferases is well known, the role of these metal cations in binding the substrates (uridine 5'-triphosphate, glucose-1-
Pohl Nicola L, Camci-Unal Gulden, Zea Corbin J   +2 more
doaj   +1 more source

Elucidation of DNA Primase as a Drug Target in Leishmania donovani: Structure‐Guided Inhibitor Identification and Biochemical Validation

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
Structure‐guided and biochemical analyses indicate that DNA primase of Leishmania donovani represents a potential therapeutic target, as repurposed compounds, particularly Pritelivir, demonstrate marked inhibitory effects accompanied by reduced parasite proliferation, replication, and altered cellular morphology in in vitro and cell‐based studies ...
Deep Bhowmik, Anupama Sharma, Ravi Prakash Arya, Diwakar Kumar   +3 more
wiley   +1 more source

Characterization of the Microbial Resistome in Conventional and “Raised Without Antibiotics” Beef and Dairy Production Systems

Frontiers in Microbiology, 2019
Metagenomic investigations have the potential to provide unprecedented insights into microbial ecologies, such as those relating to antimicrobial resistance (AMR).
Pablo Rovira, Tim McAllister, Steven M. Lakin, Shaun R. Cook, Enrique Doster, Noelle R. Noyes, Maggie D. Weinroth, Xiang Yang, Jennifer K. Parker, Christina Boucher, Calvin W. Booker, Dale R. Woerner, Keith E. Belk, Paul S. Morley   +13 more
doaj   +1 more source

Epigenetic Aging in Brain Tissue of the Self‐Fertilizing Vertebrate, Kryptolebias marmoratus

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Using the self‐fertilizing vertebrate Kryptolebias marmoratus, we developed an epigenetic clock from brain tissue that predicts chronological age with high accuracy, demonstrating that DNA methylation changes consistently with age even in the near absence of genetic variation. The 40 age‐associated CpG sites identified map to genes with conserved roles
Justine Bélik, Frédéric Silvestre
wiley   +1 more source

Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins

Nature Communications
Nucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance.
Tom J. Arrowsmith, Xibing Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower   +8 more
doaj   +1 more source

The toxin–antitoxin complex Fic‐1–AntF functions as a deAMPylase that regulates the activity of DNA gyrase

mLife, Volume 5, Issue 3, Page 301-311, June 2026.
Abstract Toxin–antitoxin (TA) systems found in diverse bacteria play important roles in their adaptation to changing environments. The toxin of the Fic‐1–AntF TA pair from Pseudomonas bijieensis strain 2P24 inhibits bacterial DNA replication by attacking the subunit B of DNA gyrase (GyrB) via AMPylation, while the antitoxin AntF blocks its enzymatic ...
Furong Chen, Liwei Guo, Canhua Lu, Wenjun Jiang, Zhao‐Qing Luo, Junfeng Liu, Li‐Qun Zhang   +6 more
wiley   +1 more source

Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics

Biology Direct, 2012
Background Proteinaceous toxins are observed across all levels of inter-organismal and intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin systems implicated in intra-specific conflicts.
Zhang Dapeng, de Souza Robson F, Anantharaman Vivek, Iyer Lakshminarayan M, Aravind L   +4 more
doaj   +1 more source

Whole‐Genome Sequence Profiling of Listeria innocua From Different Sources: Implications for Public Health

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
The studied strains, LIN_NWU_CNKT and LIN5_NWU_CNKT, exhibit invasiveness, pathogenicity, and MDR profiles. The isolation of these strains from food products and water underscores their significant public health implications, particularly in the context of the “One Health” concept.
Christ‐Donald Kaptchouang Tchatchouang, Daniel Jesuwenu Ajose, Giulia Amagliani, Collins Njie Ateba   +3 more
wiley   +1 more source

Antimicrobial Effect of Spices and Their Phytochemicals: A Novel Approach to Overcoming Antibiotic Resistance

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract shows the antibacterial potential of phytochemicals from 15 spices, showcasing key compounds, their extraction methods, and mechanisms of action. It highlights membrane disruption, ROS generation, enzyme inhibition, and biofilm prevention as core antibacterial pathways.
Hettiyahandi Binodh De Silva, Yanqi Dai, Shervanthi Homer‐Vanniasinkam, Mohan Edirisinghe   +3 more
wiley   +1 more source

Biochemical Engineering Perspective on cGAS: From Enzyme Discovery to Potential Industrial Application

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
This review examines the structural and enzymatic properties of cyclic GMP‐AMP synthase, including substrate promiscuity, homologs, and engineered variants. In addition, it evaluates potential expression systems for large‐scale enzyme production and analyzes reaction and purification strategies for the synthesis of cyclic dinucleotides to connect ...
Makram Fataeri, Katrin Rosenthal
wiley   +1 more source