Results 61 to 70 of about 7,865 (199)

Two Classes of Silencing RNAs Move between Caenorhabditis elegans Tissues [PDF]

, 2013
Organism-wide RNA interference (RNAi) is due to the transport of mobile silencing RNA throughout the organism, but the identities of these mobile RNA species in animals are unknown. Here, we present genetic evidence that both the initial double-stranded
Garcia, Giancarlo, Hunter, Craig P., Jose, Antony Merlin   +2 more
core   +1 more source

The Terminal Nucleotidyltransferase of Calf Thymus Nuclei

Journal of Biological Chemistry, 1966
Abstract An enzyme from calf thymus nuclei which incorporates ribonucleotides or deoxyribonucleotides into terminal positions of deoxyribonucleic acid has been purified and its mechanism of action elucidated. Distinctions between this enzyme and replicative deoxynucleotidyltransferase (DNA polymerase), the terminal deoxynucleotidyltransferase of calf ...
M E, Gottesman, E S, Canellakis
openaire   +2 more sources

Small Extracellular Vesicles in Gestational Diabetes Mellitus: Current Landscape and Emerging Diagnostic Horizons

Journal of Extracellular Biology, Volume 5, Issue 3, March 2026.
ABSTRACT Gestational diabetes mellitus (GDM) is a common metabolic disorder of pregnancy associated with significant maternal and neonatal morbidity and mortality. Current diagnostic strategies, particularly the oral glucose tolerance test (OGTT), are limited by late detection, variability in diagnostic criteria, and patient burden, highlighting the ...
Mai Ahmed, Dada Oluwaseyi Temilola, Mushi Matjila, Manogari Chetty   +3 more
wiley   +1 more source

Inducible auto-phosphorylation regulates a widespread family of nucleotidyltransferase toxins

Nature Communications
Nucleotidyltransferases (NTases) control diverse physiological processes, including RNA modification, DNA replication and repair, and antibiotic resistance.
Tom J. Arrowsmith, Xibing Xu, Shangze Xu, Ben Usher, Peter Stokes, Megan Guest, Agnieszka K. Bronowska, Pierre Genevaux, Tim R. Blower   +8 more
doaj   +1 more source

Results of A Local Combination Therapy Antibiogram For \u3cem\u3ePseudomonas Aeruginosa\u3c/em\u3e Isolates: Is Double Worth The Trouble? [PDF]

, 2017
Purpose: To determine the frequency at which fluoroquinolones and aminoglycosides demonstrate in vitro activity against non-urinary, non-skin/skin structure Pseudomonas aeruginosa isolates exhibiting decreased susceptibilities to one or more β-lactam ...
Davis, Jim, Dilworth, Thomas J., Elshaboury, Ramy, Munson, Erik, Song, Matthew   +4 more
core   +1 more source

The potato cyst nematode Globodera pallida overcomes major potato resistance through selection on standing variation at a single locus

New Phytologist, Volume 249, Issue 6, Page 3039-3059, March 2026.
Summary Globodera pallida poses a major threat to potato production, with management strategies primarily relying on genetic resistance. However, increasing virulence in field populations across Western Europe raises major concerns for G. pallida control.
Arno S. Schaveling, Dennie M. te Molder, Paul Heeres, Joris J. M. van Steenbrugge, Stefan J. S. van de Ruitenbeek, Casper C. van Schaik, Sven van den Elsen, Geert Smant, Mark G. Sterken   +8 more
wiley   +1 more source

Polymorphic toxin systems: Comprehensive characterization of trafficking modes, processing, mechanisms of action, immunity and ecology using comparative genomics

Biology Direct, 2012
Background Proteinaceous toxins are observed across all levels of inter-organismal and intra-genomic conflicts. These include recently discovered prokaryotic polymorphic toxin systems implicated in intra-specific conflicts.
Zhang Dapeng, de Souza Robson F, Anantharaman Vivek, Iyer Lakshminarayan M, Aravind L   +4 more
doaj   +1 more source

6-O-Nucleotidyltransferase: an aminoglycoside-modifying enzyme specific for streptomycin/streptidine [PDF]

, 2016
Aminoglycosides are especially useful for the treatment of hospital-acquired infections. The main problem for the application of these antibiotics is the presence of bacterial resistance enzymes, in particular, nucleotidyltransferases (ANTs).
Bastida, Agatha, García-Junceda, Eduardo, Latorre, Montserrat, Revuelta, Julia   +3 more
core   +1 more source

Virulence Regulation and Lifestyle Transitions: The Role of c‐di‐GMP and Two‐Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales

Molecular Plant Pathology, Volume 27, Issue 2, February 2026.
Erwinia amylovora infects apple blossoms by activating the T3SS, then spreads systemically via amylovoran‐mediated biofilms. Transitions between motile and sessile states are regulated by key two‐component systems and c‐di‐GMP. This review summarises infection biology, virulence factors, regulatory networks and evolutionary insights underlying fire ...
Dhirendra Niroula, Kalyani Bhandari, George W. Sundin, Janak R. Joshi   +3 more
wiley   +1 more source

Clinical Efficacy of Traditional Chinese Medicine Chaihu‐Guizhi‐Ganjiang Decoction Combined With Danggui‐Shaoyao‐San for the Treatment of Oligomenorrhea: A Prospective, Open‐Label Clinical Study

International Journal of Clinical Practice, Volume 2026, Issue 1, 2026.
Objective To assess the efficacy and safety of Chaihu‐Guizhi‐Ganjiang decoction (CGGJD) combined with Danggui‐Shaoyao‐San (DS) in oligomenorrhea treatment. Methods In this prospective open‐label trial, 35 oligomenorrhea patients (30–40 years) received CGGJD‐DS for 3 months, followed by a 2‐month follow‐up.
Mei Yu, Gui-Yan Liu, Wen-Xuan Zhou, Zhao-Hua Liu, Lian-Tao Li, Jin Chai   +5 more
wiley   +1 more source