Results 71 to 80 of about 7,865 (199)

The 3' to 5' exoribonuclease DIS3: from structure and mechanisms to biological functions and role in human disease [PDF]

, 2015
DIS3 is a conserved exoribonuclease and catalytic subunit of the exosome, a protein complex involved in the 3’ to 5’ degradation and processing of both nuclear and cytoplasmic RNA species.
Carazo-Salas, Drach, Kinoshita, Lim, Noguchi, Ohkura, Sazer, Suzuki   +7 more
core   +2 more sources

Characterization of Giant Myoviridae With Therapeutic Potential Against Grouper Pathogen, Vibrio alginolyticus

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Background Vibrio alginolyticus is a gram‐negative bacterium responsible for mass mortality in cultured groupers, leading to significant economic losses in the aquaculture industry. Although preventive measures such as chemical treatments, antibiotics, and pesticides have been employed, these methods have been reported to be toxic to the environment ...
Mohammad Tamrin Mohamad Lal, Rafidah Othman, Elliecpearl Jasca Joning, Gilbert Ringgit, Nor Azman Kasan, Motohiko Sano, Ibnu Bangkit Bioshina Suryadi, Attabik Mukhamad Amrillah, Julian Ransangan, Esha Saini   +9 more
wiley   +1 more source

Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirs [PDF]

, 2013
Rates of infection with antibiotic-resistant bacteria have increased precipitously over the past several decades, with far-reaching healthcare and societal costs.
Ahmadi, Sara, Dantas, Gautam, Forsberg, Kevin J, Gibson, Molly K, Pehrsson, Erica C   +4 more
core   +2 more sources

The inhibition of deoxyribonucleic acid nucleotidyltransferase by stilboestrol derivatives [PDF]

Biochemical Journal, 1968
The inhibition by diethylstilboestrol of DNA nucleotidyltransferase isolated from calf thymus was studied. The inhibition exercised by diethylstilboestrol appears to obey competitive kinetics with respect to DNA primer. The activities of both replicative and terminal enzymes were affected to the same extent. There was no evidence of binding between DNA
A R, Fahmy, K, Griffiths
openaire   +2 more sources

Mapping the Threat: A Scoping Review of Acinetobacter baumannii–Associated Hospital Infections and Resistance Mechanisms

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Background Acinetobacter baumannii is a major cause of hospital‐associated infections (HAIs) globally, particularly in intensive care units (ICUs). Its remarkable environmental resilience and ability to acquire extensive antimicrobial resistance (AMR) have made it a critical threat to patient safety and a top priority pathogen according to the World ...
Yussif Owusu Aboagye, Muhi-deen Wonwana Mohammed, Kwame Kumi Asare, Mohamed Salah Abbassi   +3 more
wiley   +1 more source

Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids [PDF]

, 2010
Background p27(Kip1) is a cyclin-dependent kinase inhibitor that inhibits G1-to-S phase transition of the cell cycle. It is known that a relatively large number of nutritional and chemopreventive anti-cancer agents specifically up-regulate expression of ...
Isao Eto
core   +1 more source

Integrative Bioinformatics and Machine Learning Identify Novel Diagnostic Biomarkers and Molecular Mechanisms in Sjögren’s Syndrome

International Journal of Genomics, Volume 2026, Issue 1, 2026.
Background Sjögren’s syndrome (SS) is a chronic autoimmune disorder characterized by significant diagnostic challenges due to nonspecific symptoms and a lack of reliable biomarkers, often resulting in delayed diagnosis and suboptimal patient management.
Hua Xu, Yong Liu, Yuyin Song, Yifan Zheng, Haifeng Jing, Yanfei Gao, Depeng Zhou, Xiang Chi, Jia Chen, Zhengrui Li   +9 more
wiley   +1 more source

Expanding the diversity of mycobacteriophages: Insights into genome architecture and evolution [PDF]

, 2011
Mycobacteriophages are viruses that infect mycobacterial hosts such as Mycobacterium smegmatis and Mycobacterium tuberculosis. All mycobacteriophages characterized to date are dsDNA tailed phages, and have either siphoviral or myoviral morphotypes ...
Agustin, B, Al-Atrache, Z, Alcoser, TA, Alexander, LM, Alfano, MB, Alford, ST, Amy, NE, Anderson, AG, Anderson, MD, Ang, AAS, Barber, AJ, Barker, LP, Barrett, JM, Barshop, WD, Bauerle, CM, Bayles, IM, Belfield, KL, Best, AA, Bowman, CA, Boyer, CA, Bradley, KW, Bradley, VA, Broadway, LN, Budwal, K, Busby, KN, Campbell, AM, Campbell, IW, Carey, A, Caruso, SM, Chew, RD, Cockburn, CL, Cohen, LB, Corajod, JM, Cresawn, SG, Davis, KR, Deng, L, Denver, DR, Dixon, BR, Ekram, S, Elgin, SCR, Engelsen, AE, English, BEV, Erb, ML, Estrada, C, Filliger, LZ, Findley, AM, Forbes, L, Forsyth, MH, Fox, TM, Fritz, MJ, Garcia, R, George, ZD, Georges, AE, Gissendanner, CR, Goff, S, Goldstein, R, Gordon, KC, Green, RD, Guerra, SL, Guiney-Olsen, KR, Guiza, BG, Haghighat, L, Hagopian, GV, Harmon, CJ, Harmson, JS, Hartzog, GA, Harvey, SE, He, KJ, He, S, Healy, KE, Higinbotham, ER, Hildebrandt, EN, Ho, JH, Hogan, GM, Hohenstein, VG, Holz, NA, Huang, VJ, Hufford, EL, Hynes, PM, Jackson, AS, Jacobs-Sera, D, Jansen, EC, Jarvik, J, Jasinto, PG, Jordan, TC, Kasza, T, Katelyn, MA, Kelsey, JS, Kerrigan, LA, Khaw, D, Kim, J, Knutter, JZ, Ko, CC, Larkin, GV, Laroche, JR, Latif, A, Manuel, A, Peebles, CL, Pope, WH, Russel, DA   +99 more
core   +1 more source

Exploring the Potential Mechanism of Umbilical Cord Mesenchymal Stem Cell Therapy for Chronic Atrophic Gastritis Based on Multi‐Omics Technology

Stem Cells International, Volume 2026, Issue 1, 2026.
Background Chronic atrophic gastritis (CAG), a prevalent gastrointestinal disorder, is characterized by gastric mucosal atrophy and increased cancer risk. Mesenchymal stem cells (MSCs) exhibit immunomodulatory, anti‐inflammatory, and tissue‐regenerative properties; however, their therapeutic potential for CAG remains underexplored.
Pengchao Bai, Qichao Liu, Miaomiao Yin, Yan Liu, Jianliang Sui, Saihan Wang, Ruikang Jia, Huiyun Liu, Feiyue Zhao, Alain Chapel   +9 more
wiley   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, Volume 15, Issue 12, Page 2001-2020, December 2025.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source