Results 91 to 100 of about 1,773 (158)

Probing carbohydrate biocatalysis through the use of electrospray ionization mass spectrometry and isothermal titration calorimetry [PDF]

, 2005
Electrospray ionization mass spectrometry,(ESI-MS)-based assays have been newly developed to study three classes of enzymes (sugar nucleotidyltransferases, glycosyltransferases, and phosphorylases) from the three distinct families of life: archaea ...
Zea, Corbin
core   +1 more source

Studies of Enzymes That Cause Resistance to Aminoglycosides Antibiotics

, 2008
Aminoglycoside antibiotics are highly potent, wide-spectrum bactericidals (1, 2). Bacterial resistance to aminoglycosides, however, is a major problem in the clinical use of aminoglycosides.
Özen, Can, Edward Wright, Serpersu, Engin H, Wright, Edward, Can Özen, Engin H. Serpersu   +5 more
core   +1 more source

A tale of non-canonical tails: gene regulation by post-transcriptional RNA tailing

, 2020
© 2020, Springer Nature Limited. RNA tailing, or the addition of non-templated nucleotides to the 3′ end of RNA, is the most frequent and conserved type of RNA modification.
Yu, Sha, Kim, V. Narry, Sha Yu, V. Narry Kim   +3 more
core   +1 more source

Strategies for the Chemoenzymatic Synthesis of Deoxysugar Nucleotides:  Substrate Binding versus Catalysis

, 2016
Sugar nucleotidyltransferases, also known as sugar pyrophosphorylases, catalyze the formation of a phosphate linkage to produce sugars activated for use by Leloir pathway glycosyltransferases and are subjects of protein engineering for chemoenzymatic ...
Corbin J. Zea (2186041), Kwang-Seuk Ko (1572745), Nicola L. Pohl (2295247)   +2 more
core   +1 more source

Bacterial 2′,3′-cGAMP activates a SAVED effector to form membrane-disrupting filaments and restrict phage replication

Cell Host and Microbe
Summary Mammalian cells initiate antiviral signaling when cGAS detects cytoplasmic DNA and synthesizes 2′,3′-cGAMP, which activates STING. Similarly, bacteria use cyclic oligonucleotide-based antiphage signaling systems (CBASS) to detect phage using ...
U. Tak, Kate Schinkel, Peace Walth, Jian-Wei Tay, Erik W. Hartwick, Aaron T. Whiteley   +5 more
semanticscholar   +1 more source

Phylogenetic neighbor-joining tree of aminoglycoside nucleotidyltransferases (ANT(3")).

, 2017
Numbers above each node are the percentages of tree configurations that occurred during 1000 bootstrap replicates. Only values greater than 70% are shown. The abbreviation of bacteria denoted as follow: E. coli, Escherichia coli; P.
Koji Yahara (210105), Jie Feng (8115), Gang Zhang (377046), Sébastien Olivier Leclercq (3712441), Shuangjiang Liu (3712444), Jingjing Tian (1545049), Chao Wang (146527), Guomin Ai (165362)   +7 more
core   +1 more source

Recognition of TMV RNA by the tRNA nucleotidyltransferase [PDF]

FEBS Letters, 1974
Benicourt, Claude, Haenni, Anne-Lise
openaire   +2 more sources

Dysregulation of a nucleotidyltransferase induces division and surface glycan defects in Escherichia coli by altering related metabolite levels

Proceedings of the National Academy of Sciences of the United States of America
Significance Bacterial nucleotidyltransferases synthesize precursors for virulence factors like surface polysaccharides and often are regulated via feedback inhibition.
Maggie C. Zheng, J. Bryant, Andrea Koid, Mia Sheshova, Hanee Kim, Matthew A. Jorgenson, Tania J. Lupoli   +6 more
semanticscholar   +1 more source

Nucleotidyltransferase [PDF]

, 2020
openaire   +1 more source

Catalytic Mechanism and Allosteric Regulation of UDP-Glucose Pyrophosphorylase from Leishmania major

, 2016
UDP-glucose pyrophosphorylase (UGP) is a nucleotidyltransferase of central importance in all organisms and considered an attractive drug target in the human pathogens Leishmania and Trypanosoma.
Rita Gerardy-Schahn (37787), Françoise H. Routier (1874065), Johannes T. Cramer (1874068), Anne-Christin Lamerz (1874077), Jana Führing (1874071), Roman Fedorov (22980), Petra Baruch (1874074)   +6 more
core   +1 more source