Results 31 to 40 of about 1,423 (95)

Decreased phosphatidylcholine biosynthesis and abnormal distribution of CTP:phosphocholine cytidylyltransferase in cholesterol auxotrophic Chinese hamster ovary cells

Journal of Lipid Research, 1997
Phosphatidylcholine (PtdCho) biosynthesis was examined in the sterol regulatory defective (SRD) Chinese hamster ovary (CHO) cell line SRD 6. SRD 6 cells do not display transcriptional activation of sterol-regulated genes and are cholesterol auxotrophs ...
M K Storey, D M Byers, H W Cook, N D Ridgway   +3 more
doaj   +1 more source

Rhodotorula glutinis as a living cell liposome to deliver polypeptide drugs in vivo

Drug Delivery, 2019
The potential advantages of recombinant microbes as oral drug carriers for curing diseases have attracted much attention. The use of recombinant oil microbes as living cell liposomes to carry polypeptide drugs may be an ideal polypeptide oral drug ...
Zhengbin Fei, Shiyu Li, Jiajia Wang, Yuzhe Wang, Zhenyou Jiang, Wenhua Huang, Hanxiao Sun   +6 more
doaj   +1 more source

The Inner Nuclear Membrane Has a Unique Lipid Signature. [PDF]

Bioessays
The inner nuclear membrane (INM) has a distinct lipid profile, most notably characterized by high enrichment of phosphatidylserine (PS). In this review, Yang Niu and Tamas Balla summarize recent advances in elucidating the INM's lipid composition and related metabolic pathways, while elaborating further on their potential functional roles.
Niu Y, Balla T.
europepmc   +2 more sources

Molecular Responses to Climate Change: How Warming and Acidification Reshape the Proteome and Phosphoproteome of the Endangered Mira Chub

Ecology and Evolution, Volume 16, Issue 3, March 2026.
ABSTRACT Global environmental change affects organisms, including their physiology. In freshwater ecosystems, where migration is limited, populations often rely on phenotypic plasticity to respond. While transcriptomics has been widely used to study stress responses at the molecular level, less is known about the proteome, which reflects post ...
João M. Moreno, Jonas Grossmann, Laura Kunz, Antje Dittmann, Vitor C. Sousa, Romana Santos   +5 more
wiley   +1 more source

β-Hydroxybutyrate in subclinical ketosis promotes endoplasmic reticulum biogenesis and milk protein synthesis via IRE1α-XBP1 in bovine mammary epithelial cells

Journal of Dairy Science
: Subclinical ketosis in dairy cows is accompanied by adaptive changes in the secretory function of the mammary gland. However, the molecular basis underlying this adaptation remains unclear.
Liguang Cao, Jiatong Han, Guojin Li, Kai Liu, Wenrui Gao, Zifeng Yang, Yifei Dong, Yushan Du, Xiliang Du, Yuxiang Song, Xinwei Li, Lin Lei, Wenwen Gao, Guowen Liu   +13 more
doaj   +1 more source

Gene Expression, Docking and Machine Learning in Malaria Drug Discovery: A Systematic Review

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Background Malaria remains a significant and worldwide health threat with increasing resistance to current treatments, stimulating the demand for innovative approaches in pursuing drug discovery. This systematic review integrates the progress made from 2014 through 2024 regarding molecular methods like gene expression profiling, molecular docking and ...
Reuben Samson Dangana, Israel Ehizuelen Ebhohimen, Samson Anjikwi Malgwi, Samuel Chima Ugbaja, Moses Okpeku, Harleen Khatra   +5 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, Volume 599, Issue 24, Page 3569-3590, December 2025.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Multi‐omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley   +1 more source

Differential Effects of Liver Regeneration on Aging‐Related Changes in Gene Expression and Metabolic Function

Aging Cell, Volume 24, Issue 10, October 2025.
The age‐specific gene expression status of aged mouse hepatocytes is mostly resolved and rejuvenated when liver regeneration is completed; whereas the age‐specific intracellular metabolic status detected in the liver of aged mice is largely maintained and not rejuvenated even after liver regeneration is completed.
Ryo Murayama, Kenichi Horisawa, Shizuka Miura, Sumiaki Taniguchi, Jinghao Shu, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Kousei Ishigami, Atsushi Suzuki   +9 more
wiley   +1 more source

CTP: Choline Phosphate Cytidylyltransferase in human lung

, 1988
Human lung cytidylyltransferase was found associated with both 'soluble' (S100) and membrane-rich particulate (P100) fractions of Tris-buffered saline homogenates. S100 enzyme activities in 15 - 16 week fetal and adult human lungs represented a constant proportion of overall recovery, (66.8 4.8% vs 66.1 7.5%, means standard error).
openaire   +2 more sources