Results 211 to 220 of about 236,274 (244)
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CRC Critical Reviews in Biochemistry, 1977
Acetylcholine is essential to neural function. It synthesis is catalyzed by choline acetyltransferase, the enzyme responsible for the acetylation of choline by acetyl coenzye A, a reaction favored slightly thermodymodynamically and not at all kinetically. An analytically pure enzyme still has not been obtained; however, method of purification have been
Henry G. Mautner, David Nachmansohn
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Acetylcholine is essential to neural function. It synthesis is catalyzed by choline acetyltransferase, the enzyme responsible for the acetylation of choline by acetyl coenzye A, a reaction favored slightly thermodymodynamically and not at all kinetically. An analytically pure enzyme still has not been obtained; however, method of purification have been
Henry G. Mautner, David Nachmansohn
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Choline oxidation and choline dehydrogenase
Journal of Protein Chemistry, 1986The oxidation of choline by both freshly prepared and aged rat liver mitochondria is inhibited by amytal. Whereas rotenone inhibits choline-cytochromec reductase only in the case of freshly prepared mitochondria, the extent of inhibition is influenced by preincubation, but the inhibition is not secondary to the inhibited oxidation of betaine aldehyde ...
Chi-Shui Lin, Ru-Dan Wu
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Biosensors for choline, choline esters and inhibitors of choline esterase
Sensors and Actuators B: Chemical, 1991Abstract A choline electrode has been developed by coupling immobilized choline oxidase to a hydrogen peroxide electrode. The co-immobilization of cholinesterase permits acetylcholine to be measured. The excess of both enzymes results in a diffusion-limited electrode response for both substrates, with relative sensitivities 1: 0.6 for choline ...
U. Löffler +5 more
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Drug Development and Industrial Pharmacy, 2002
Choline has many physiological functions throughout the body that are dependent on its available local supply. However, since choline is a charged hydrophilic cation, transport mechanisms are required for it to cross biological membranes. Choline transport is required for cellular membrane construction and is the rate-limiting step for acetylcholine ...
Paul R. Lockman, David D. Allen
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Choline has many physiological functions throughout the body that are dependent on its available local supply. However, since choline is a charged hydrophilic cation, transport mechanisms are required for it to cross biological membranes. Choline transport is required for cellular membrane construction and is the rate-limiting step for acetylcholine ...
Paul R. Lockman, David D. Allen
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The Relationship of Choline and Carnitine in the Choline Deficient Rat
The Journal of Nutrition, 1978Levels of carnitine in choline deficient and choline supplemented rats were measured in heart, skeletal muscle, plasma, and liver after various treatments. A decreased hepatic concentration of carnitine was shown to be closely correlated to the deficiency in dietary choline.
Alva Lee Carter, Rene Frenkel
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CHOLINE AND ACETYLCHOLINE IN RATS: EFFECT OF DIETARY CHOLINE
Journal of Neurochemistry, 1976Abstract– The concentration of free choline in peripheral tissues (duodenum, heart, kidney, liver, stomach and plasma) of rats was found to be related to the amount of free choline in the diet. Under steady‐state conditions, the concentration of free choline in plasma varied from a minimum of approx 6 nmol/ml (in rats fed a choline‐deficient diet) to a
Elizabeth Anne Proctor +3 more
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The Journal of Pharmacology and Experimental Therapeutics, 1993
The pharmacological actions of the novel choline analog, selenonium choline [(CH3)2Se+CH2CH2OH] and its acetyl ester acetylselenonium choline (ASeCh) were studied in vivo and in vitro. ASeCh produced a dose-related decrease in mean arterial pressure in the rat similar to acetylcholine (ACh) but was 1% to 2% as potent.
A V, Terry +4 more
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The pharmacological actions of the novel choline analog, selenonium choline [(CH3)2Se+CH2CH2OH] and its acetyl ester acetylselenonium choline (ASeCh) were studied in vivo and in vitro. ASeCh produced a dose-related decrease in mean arterial pressure in the rat similar to acetylcholine (ACh) but was 1% to 2% as potent.
A V, Terry +4 more
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N‐SUBSTITUTED CHOLINE ANALOGUES AS SUBSTRATES FOR CHOLINE ACETYLTRANSFERASE
Journal of Neurochemistry, 1979Abstract— Alkyl, phenyl, phenylalkyl and pyridiniumalkyl derivatives of choline were studied as substrates for choline acetyltransferase from bovine brain. When one methyl group of choline was replaced by an ethyl group, pKm (negative logarithm of apparent Km) decreased, whereas Vmax was not significantly changed in comparison with choline.
B. Sörbo, J. Sollenberg, K.-E. Stensiö
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Inhibition of choline acetyltransferase by quaternary ammonium analogues of choline
Biochemical Pharmacology, 1975Abstract The effects of the choline analogues hemicholinium-3, triethylcholine, tetraethylammonium and acetylcholine on the synthesis of ACh by choline acetyltransferase have been studied in vitro. Hemicholinium-3 is shown to be an inhibitor of choline acetyltransferase with a Ki of 2·5 mM. HC-3, TEA and ACh are competitive with choline.
S. P. Mann, Catherine Hebb
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2020
Choline oxidase catalyzes the four-electron, two-step, flavin-mediated oxidation of choline to glycine betaine. The enzyme is important both for medical and biotechnological reasons, because glycine betaine is one among a limited number of compatible solutes used by cells to counteract osmotic pressure.
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Choline oxidase catalyzes the four-electron, two-step, flavin-mediated oxidation of choline to glycine betaine. The enzyme is important both for medical and biotechnological reasons, because glycine betaine is one among a limited number of compatible solutes used by cells to counteract osmotic pressure.
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