Systemic administration of choline acetyltransferase decreases blood pressure in murine hypertension [PDF]
Molecular Medicine, 2021 Acetylcholine (ACh) decreases blood pressure by stimulating endothelium nitric oxide-dependent vasodilation in resistance arterioles. Normal plasma contains choline acetyltransferase (ChAT) and its biosynthetic product ACh at appreciable concentrations ...
Andrew Stiegler +9 more
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Evaluation of the Activity of Choline Acetyltransferase From Different Synaptosomal Fractions at the Distinct Stages of Spatial Learning in the Morris Water Maze [PDF]
Frontiers in Behavioral Neuroscience, 2021 Accumulated data have evidenced that brain cholinergic circuits play a crucial role in learning and memory; however, our knowledge about the participation of neocortical and hippocampal cholinergic systems in spatial learning needs to be refined. The aim
Zinaida I. Storozheva +2 more
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The effect of genetic variations in the choline acetyltransferase gene (ChAT) on waterpipe tobacco smoking dependence [PDF]
Tobacco Induced Diseases, 2020 Introduction Waterpipe tobacco smoking (WS) is a popular form of tobacco use, globally. While the impact of genetic variations on smoking behavior has been well-investigated, few studies have examined this issue with regard to WS.
Omar F. Khabour +4 more
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Choline acetyltransferase detection in normal and denervated electrocyte from Electrophorus electricus (L.) using a Confocal Scanning Optical Microscopy Analysis [PDF]
Anais da Academia Brasileira de Ciências, 2000 Acetylcholine is the neurotransmitter responsible for the transmission of impulses from cholinergic neurons to cells of innervated tissues. Its biosynthesis is catalyzed by the enzyme Choline acetyltransferase that is considered to be a phenotypically ...
NILSON NUNES-TAVARES +2 more
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The ‘compartmentation’ of choline acetyltransferase within the synaptosome [PDF]
Biochemical Journal, 1967 1. Choline acetyltransferase may be isolated in either a bound or soluble form after hypo-osmotic treatment of a crude synaptosome fraction, depending on the conditions. 2. In the bound form, the enzyme appears to be associated with the larger membrane fragments rather than with synaptic vesicles. 3.
Frode Fonnum
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Soluble Aβ42 Acts as Allosteric Activator of the Core Cholinergic Enzyme Choline Acetyltransferase [PDF]
Frontiers in Molecular Neuroscience, 2018 Two major questions in the field of Alzheimer-type dementia remain elusive. One is the native function of amyloid-β (Aβ) peptides and the other is an early deficit in the central cholinergic network.
Amit Kumar +4 more
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A Novel Antiserum Against a Predicted Human Peripheral Choline Acetyltransferase (hpChAT) for Labeling Neuronal Structures in Human Colon [PDF]
Frontiers in Neuroanatomy, 2019 Choline acetyltransferase (ChAT), the enzyme synthesizing acetylcholine (ACh), has an exon-skipping splice variant which is expressed preferentially in the peripheral nervous system (PNS) and thus termed peripheral ChAT (pChAT).
Jean-Pierre Bellier +7 more
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Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. [PDF]
PLoS ONE, 2017 Prevention of Alzheimer's disease (AD) is a major goal of biomedical sciences. In previous studies we showed that high intake of the essential nutrient, choline, during gestation prevented age-related memory decline in a rat model.
Tiffany J Mellott +6 more
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Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the teleost Cyprinus carpio [PDF]
European Journal of Histochemistry, 2018 Cholinergic systems play a role in basic cerebral functions and its dysfunction is associated with deficit in neurodegenerative disease. Mechanisms involved in human brain diseases, are often approached by using fish models, especially cyprinids, given ...
Arianna Casini +3 more
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Effect of Chronic Tibolone Administration on Memory and Choline Acetyltransferase and Tryptophan Hydroxylase Content in Aging Mice [PDF]
Brain SciencesGonadal steroids exert different effects on the central nervous system (CNS), such as preserving neuronal function and promoting neuronal survival.
Tzayaka Castillo-Mendieta +7 more
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