Results 1 to 10 of about 195,821 (248)
Muscarinic receptor M3 activation promotes fibrocytes contraction
Frontiers in Pharmacology, 2022 Fibrocytes are monocyte-derived cells able to differentiate into myofibroblasts-like cells. We have previously shown that they are increased in the bronchi of Chronic Obstructive Pulmonary Disease (COPD) patients and associated to worse lung function ...
Pauline Henrot +19 more
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Frontiers in Pharmacology, 2018 Nicotinic acetylcholine receptors (nAChRs) expressed on the cell plasma membrane are ligand-gated ion channels mediating fast synaptic transmission, regulating neurotransmitter and cytokine release and supporting the viability of many cell types.
Kateryna Uspenska +6 more
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Experimental Pharmacology in Transgenic Rodent Models of Alzheimer’s Disease
Frontiers in Pharmacology, 2019 This Mini Review discusses the merits and shortfalls of transgenic (tg) rodents modeling aspects of the human Alzheimer’s disease (AD) pathology and their application to evaluate experimental therapeutics.
A. Claudio Cuello +4 more
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Alzheimer’s Disease: Current and Future Treatments. A Review
International Journal of Medical Students, 2014 Alzheimer’s disease (AD) is a currently incurable neurodegenerative disorder whose treatment poses a big challenge. Proposed causes of AD include the cholinergic, amyloid and tau hypotheses.
Evelyn Chou
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Systematic review of the pharmacological properties of oligodendrocyte lineage
Frontiers in Cellular Neuroscience, 2016 OOligodendrogenesis and oligodendrocyte precursor maturation are essential processes during the course of central nervous system development, and lead to the myelination of axons.
Carla eMarinelli +4 more
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Physiological Reports, 2022 Vitronectin (VTN) is a glycoprotein enriched in the blood and activates integrin receptors. VTN blood levels increase only in female mice 24 h after an ischemic stroke and exacerbate brain injury through IL‐6‐driven inflammation, but the VTN induction ...
Matthew P. Keasey +3 more
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Antidepressant effect of methanol stem bark extract of Adansonia digitata: involvement of monoaminergic, nitric oxide and cholinergic pathways [PDF]
Journal of HerbMed Pharmacology, 2021 Introduction: Hausa people of north-western Nigeria were reported to utilize the plant Adansonia digitata for the management of depressive illnesses in an ethnobotanical survey. Thus, this study aimed to establish the mechanism(s) via which methanol stem
Aishatu Shehu +3 more
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Corticofugal and Brainstem Functions Associated With Medial Olivocochlear Cholinergic Transmission
Frontiers in Neuroscience, 2022 Cholinergic transmission is essential for survival and reproduction, as it is involved in several physiological responses. In the auditory system, both ascending and descending auditory pathways are modulated by cholinergic transmission, affecting the ...
Felipe Munoz +9 more
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Frontiers in Molecular Neuroscience, 2017 Alzheimer’s disease (AD) is a common age-related neurodegenerative disorder that is characterized by progressive cognitive decline. The deficits in cognition and attentional processing that are observed clinically in AD are linked to impaired function of
Leah K. Cuddy +7 more
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Loss of Sympathetic Nerves in Spleens from Patients with End Stage Sepsis
Frontiers in Immunology, 2017 The spleen is an important site for central regulation of immune function by noradrenergic sympathetic nerves, but little is known about this major region of neuroimmune communication in humans.
Donald B. Hoover +7 more
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