Results 21 to 30 of about 146,455 (266)
Cell type-specific long-range connections of basal forebrain circuit
eLife, 2016 The basal forebrain (BF) plays key roles in multiple brain functions, including sleep-wake regulation, attention, and learning/memory, but the long-range connections mediating these functions remain poorly characterized.
Johnny Phong Do +10 more
doaj +1 more source
Pro-cognitive drug effects modulate functional brain network organization
Frontiers in Behavioral Neuroscience, 2012 Previous studies document that cholinergic and noradrenergic drugs improve attention, memory and cognitive control in healthy subjects and patients with neuropsychiatric disorders.
Carsten eGiessing, Christiane M Thiel
doaj +1 more source
Alzheimer’s Disease, Hearing Loss, and Deviance Detection
Frontiers in Neuroscience, 2022 Age-related hearing loss is a widespread condition among the elderly, affecting communication and social participation. Given its high incidence, it is not unusual that individuals suffering from age-related hearing loss also suffer from other age ...
David Pérez-González +9 more
doaj +1 more source
Central Cholinergic Nervous System and Cholinergic Agents [PDF]
Acta Medica (Hradec Kralove, Czech Republic), 1998 Central cholinergic nervous system play important role in many physiological and behavioral functions in humans. The activity of the cholinergic nervous system depends upon the production and fate of acetylcholine and all compounds influenced its biosynthesis, storage, release, hydrolysis, interaction with different subtypes of cholinergic receptors ...
openaire +3 more sources
Adaptive short‐term associative conditioning in the pancreatic β‐cell
Physiological Reports, 2020 This study associates cholinergic stimulation of the pancreatic β‐cell electrical activity with a short‐term memory phenomenon. Glucose pulses applied to a basal glucose concentration induce depolarizing waves which are used to estimate the evolution of ...
Juan V. Sanchez‐Andres +2 more
doaj +1 more source
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild‐to‐moderate Alzheimer's disease (AD) on background donepezil 10 mg/day.
Pradeep J. Nathan +14 more
doaj +1 more source
Plants, 2022 Hesperidin (HSP) is a major flavanone glycoside in citrus fruits, including sweet oranges and lemons. It demonstrates numerous pharmacological activities, such as antihypertensive effects and cardiac and kidney tissue protection.
Priscila de Souza +5 more
doaj +1 more source
Translational PsychiatryGenome wide association and animal studies have implicated genetic variations in CHRNΑ5, encoding the α5 subunit-containing nicotinic acetylcholine receptors (α5*nAChRs), as a risk factor for developing alcohol use disorders (AUDs).
Léa Tochon +4 more
doaj +1 more source
CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao +7 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub +24 more
wiley +1 more source