Experimental Pharmacology in Transgenic Rodent Models of Alzheimer’s Disease
Frontiers in Pharmacology, 2019 This Mini Review discusses the merits and shortfalls of transgenic (tg) rodents modeling aspects of the human Alzheimer’s disease (AD) pathology and their application to evaluate experimental therapeutics.
A. Claudio Cuello +4 more
doaj +1 more source
Brain muscarinic cholinergic receptors in Huntington's disease [PDF]
, 1992 Muscarinic cholinergic receptors and choline acetyltransferase (ChAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects.
Agid, Y. +4 more
core +1 more source
Axons Giving Rise to the Palisade Endings of Feline Extraocular Muscles Display Motor Features [PDF]
, 2013 Palisade endings are nerve specializations found in the extraocular muscles (EOMs) of mammals, including primates. They have long been postulated to be proprioceptors. It was recently demonstrated that palisade endings are cholinergic and that in monkeys
Davis López de Carrizosa, María América +5 more
core +1 more source
Alzheimer’s Disease: Current and Future Treatments. A Review
International Journal of Medical Students, 2014 Alzheimer’s disease (AD) is a currently incurable neurodegenerative disorder whose treatment poses a big challenge. Proposed causes of AD include the cholinergic, amyloid and tau hypotheses.
Evelyn Chou
doaj +1 more source
Distribution of choline acetyltransferase (ChAT) immunoreactivity in the CNS of the common carp cyprinus carpio [PDF]
, 2015 Cholinergic systems play a role in basic cerebral functions and a number of human neurodegenerative disorders. Mechanisms involved in human brain diseases, including Parkinson's disease (1), are often approached by using fish models, especially cyprinids,
Casini, Arianna +3 more
core +2 more sources
Systematic review of the pharmacological properties of oligodendrocyte lineage
Frontiers in Cellular Neuroscience, 2016 OOligodendrogenesis and oligodendrocyte precursor maturation are essential processes during the course of central nervous system development, and lead to the myelination of axons.
Carla eMarinelli +4 more
doaj +1 more source
Physiological Reports, 2022 Vitronectin (VTN) is a glycoprotein enriched in the blood and activates integrin receptors. VTN blood levels increase only in female mice 24 h after an ischemic stroke and exacerbate brain injury through IL‐6‐driven inflammation, but the VTN induction ...
Matthew P. Keasey +3 more
doaj +1 more source
Alzheimer's Disease: Targeting the Cholinergic System
Current Neuropharmacology, 2016 Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The enzyme choline acetyltransferase (ChAT) is responsible for synthesizing ACh from acetyl-CoA and choline in the cytoplasm and the vesicular acetylcholine transporter
T. H. Ferreira-Vieira +3 more
semanticscholar +1 more source
Reduction in jejunal fluid absorption in vivo through distension and cholinergic stimulation not attributable to enterocyte secretion [PDF]
, 2018 Jejunal fluid absorption in vivo was reduced by distension and by hydrostatic pressure and further declined on adding E. coli STa enterotoxin but no net fluid secretion was detected.
Graham, V. +8 more
core +1 more source
Neural regulation of ILC2s in allergic airway inflammation
Frontiers in Allergy, 2023 The sympathetic nervous system (SNS) and parasympathetic nervous system (PNS) regulate the effector functions of group 2 innate lymphoid cells (ILC2s) through β2 adrenergic receptor (ADRB2) and nicotinic/muscarinic cholinergic receptor signaling ...
Christopher M. Thomas +3 more
doaj +1 more source