Results 11 to 20 of about 345,248 (352)
The Input-Output Relationship of the Cholinergic Basal Forebrain
Cell Reports, 2017 Basal forebrain cholinergic neurons influence cortical state, plasticity, learning, and attention. They collectively innervate the entire cerebral cortex, differentially controlling acetylcholine efflux across different cortical areas and timescales ...
Matthew R. Gielow, Laszlo Zaborszky
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Role of Cholinergic Signaling in Alzheimer’s Disease
Molecules, 2022 Acetylcholine, a neurotransmitter secreted by cholinergic neurons, is involved in signal transduction related to memory and learning ability. Alzheimer’s disease (AD), a progressive and commonly diagnosed neurodegenerative disease, is characterized by ...
Zhi-Ru Chen +3 more
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Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches.
Lancet Neurology, 2022 In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur in different brain regions. These changes correlate with a range of clinical features, both motor and non-motor, that are refractory to dopaminergic therapy, and can
N. Bohnen +7 more
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Cholinergic System and Its Therapeutic Importance in Inflammation and Autoimmunity
Frontiers in Immunology, 2021 Neurological and immunological signals constitute an extensive regulatory network in our body that maintains physiology and homeostasis. The cholinergic system plays a significant role in neuroimmune communication, transmitting information regarding the ...
Namrita Halder, G. Lal
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The Cholinergic System, the Adrenergic System and the Neuropathology of Alzheimer’s Disease
International Journal of Molecular Sciences, 2021 Neurodegenerative diseases are a major public health problem worldwide with a wide spectrum of symptoms and physiological effects. It has been long reported that the dysregulation of the cholinergic system and the adrenergic system are linked to the ...
R. Bekdash
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The Cholinergic Brain in Parkinson's Disease
Movement Disorders Clinical Practice, 2021 The central cholinergic system includes the basal forebrain nuclei, mainly projecting to the cortex, the mesopontine tegmental nuclei, mainly projecting to the thalamus and subcortical structures, and other groups of projecting neurons and interneurons ...
Jacopo Pasquini, D. Brooks, N. Pavese
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An optimized acetylcholine sensor for monitoring in vivo cholinergic activity
Nature Methods, 2020 The ability to directly measure acetylcholine (ACh) release is an essential step toward understanding its physiological function. Here we optimized the GRABACh (GPCR-activation-based ACh) sensor to achieve substantially improved sensitivity in ACh ...
Miao Jing +23 more
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Muscarinic receptor M3 activation promotes fibrocytes contraction
Frontiers in Pharmacology, 2022 Fibrocytes are monocyte-derived cells able to differentiate into myofibroblasts-like cells. We have previously shown that they are increased in the bronchi of Chronic Obstructive Pulmonary Disease (COPD) patients and associated to worse lung function ...
Pauline Henrot +19 more
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Frontiers in Pharmacology, 2018 Nicotinic acetylcholine receptors (nAChRs) expressed on the cell plasma membrane are ligand-gated ion channels mediating fast synaptic transmission, regulating neurotransmitter and cytokine release and supporting the viability of many cell types.
Kateryna Uspenska +6 more
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Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the teleost cyprinus carpio [PDF]
, 2018 Cholinergic systems play a role in basic cerebral functions and its dysfunction is associated with deficit in neurodegenerative disease. Mechanisms involved in human brain diseases, are often approached by using fish models, especially cyprinids, given ...
Casini, Arianna +3 more
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