Results 11 to 20 of about 195,821 (248)

Co-activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease. [PDF]

Adv Sci (Weinh)
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Lee R, Kim G, Black ER, Kim S.
europepmc   +2 more sources

Stereological sampling-based estimates of dopaminergic and cholinergic neuron numbers in young adult and aged male and female Fischer 344 × Brown Norway F1 hybrid rats [PDF]

Frontiers in Aging Neuroscience
Age is the primary risk factor for neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease, which are characterized by profound loss of midbrain dopaminergic neurons and basal forebrain cholinergic neurons, respectively.
Hannah E. Phelps, Hannah E. Phelps, Merritt R. Reese, Swetha Jeyagopal, Aryan Sahota, Wonn S. Pyon, Jennifer L. Bizon, Jennifer L. Bizon, Jennifer L. Bizon, Barry Setlow, Barry Setlow, Barry Setlow, Matthew R. Burns, Matthew R. Burns, Matthew R. Burns, Matthew R. Burns   +15 more
doaj   +2 more sources

Prolonged cholinergic enrichment influences regional cortical activation in early Alzheimer's disease [PDF]

, 2008
Neuroimaging studies of cholinesterase inhibitor (ChEI) treatment in Alzheimer's disease (AD) indicate that the short and long term actions of ChEIs are dissimilar. fMRI studies of the ChEI rivastigmine have focused on its short term action.
Shanks, Michael F, Venneri, Annalena, McGeown, William J   +2 more
core   +4 more sources

Recurrent Implication of Striatal Cholinergic Interneurons in a Range of Neurodevelopmental, Neurodegenerative, and Neuropsychiatric Disorders

Cells, 2021
Cholinergic interneurons are “gatekeepers” for striatal circuitry and play pivotal roles in attention, goal-directed actions, habit formation, and behavioral flexibility.
Lauren A. Poppi, Khue Tu Ho-Nguyen, Anna Shi, Cynthia T. Daut, Max A. Tischfield   +4 more
doaj   +1 more source

Biomolecular Screening of Pimpinella anisum L. for Antioxidant and Anticholinesterase Activity in Mice Brain

Molecules, 2023
Hundreds of the plants have been explored and evaluated for antioxidant and anti-amnesic activities, so far. This study was designed to report the biomolecules of Pimpinella anisum L. for the said activities. The aqueous extract of dried P.
Aamir Mushtaq, Fatima Habib, Rosana Manea, Rukhsana Anwar, Umar Farooq Gohar, Muhammad Zia-Ul-Haq, Mobasher Ahmad, Claudia Mihaela Gavris, Liana Chicea   +8 more
doaj   +1 more source

The Cholinergic Drug Galantamine Alleviates Oxidative Stress Alongside Anti-inflammatory and Cardio-Metabolic Effects in Subjects With the Metabolic Syndrome in a Randomized Trial

Frontiers in Immunology, 2021
Background: The metabolic syndrome (MetS) is an obesity-associated disorder of pandemic proportions and limited treatment options. Oxidative stress, low-grade inflammation and altered neural autonomic regulation, are important components and drivers of ...
Carine Teles Sangaleti, Carine Teles Sangaleti, Keyla Yukari Katayama, Kátia De Angelis, Kátia De Angelis, Tércio Lemos de Moraes, Amanda Aparecida Araújo, Heno F. Lopes, Heno F. Lopes, Cleber Camacho, Luiz Aparecido Bortolotto, Lisete Compagno Michelini, Maria Cláudia Irigoyen, Peder S. Olofsson, Peder S. Olofsson, Douglas P. Barnaby, Kevin J. Tracey, Valentin A. Pavlov, Fernanda Marciano Consolim Colombo, Fernanda Marciano Consolim Colombo   +19 more
doaj   +1 more source

The Autonomic Nervous System Pulls the Strings to Coordinate Circadian HSC Functions

Frontiers in Immunology, 2020
As for many other adult stem cells, the behavior of hematopoietic stem and progenitor cells (HSPCs) is subjected to circadian regulatory patterns. Multiple HSPC functions, such as proliferation, differentiation or trafficking exhibit time-dependent ...
Andrés García-García, Simón Méndez-Ferrer, Simón Méndez-Ferrer, Simón Méndez-Ferrer   +3 more
doaj   +1 more source

Propranolol Relieves L-Dopa-Induced Dyskinesia in Parkinsonian Mice

Brain Sciences, 2020
Background: Parkinsonism is caused by dopamine (DA) insufficiency and results in a hypokinetic movement disorder. Treatment with L-Dopa can restore DA availability and improve motor function, but patients can develop L-Dopa-induced dyskinesia (LID), a ...
Ziqing Shi, Ian J. Bamford, Jonathan W. McKinley, Suma Priya Sudarsana Devi, Annie Vahedipour, Nigel S. Bamford   +5 more
doaj   +1 more source

Acetylcholine is released in the basolateral amygdala in response to predictors of reward and enhances the learning of cue-reward contingency

eLife, 2020
The basolateral amygdala (BLA) is critical for associating initially neutral cues with appetitive and aversive stimuli and receives dense neuromodulatory acetylcholine (ACh) projections.
Richard B Crouse, Kristen Kim, Hannah M Batchelor, Eric M Girardi, Rufina Kamaletdinova, Justin Chan, Prithviraj Rajebhosale, Steven T Pittenger, Lorna W Role, David A Talmage, Miao Jing, Yulong Li, Xiao-Bing Gao, Yann S Mineur, Marina R Picciotto   +14 more
doaj   +1 more source

In silico Gene Set and Pathway Enrichment Analyses Highlight Involvement of Ion Transport in Cholinergic Pathways in Autism: Rationale for Nutritional Intervention

Frontiers in Neuroscience, 2021
Food is the primary human source of choline, an essential precursor to the neurotransmitter acetylcholine, which has a central role in signaling pathways that govern sensorimotor functions.
Audrey Olson, Audrey Olson, Fuquan Zhang, Hongbao Cao, Hongbao Cao, Ancha Baranova, Ancha Baranova, Margaret Slavin   +7 more
doaj   +1 more source