Results 41 to 50 of about 345,248 (352)
Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline.
Neuron, 2016 Recent work continues to place cholinergic circuits at center stage for normal executive and mnemonic functioning and provides compelling evidence that the loss of cholinergic signaling and cognitive decline are inextricably linked.
Elizabeth C. Ballinger +3 more
semanticscholar +1 more source
An essential role of acetylcholine-glutamate synergy at habenular synapses in nicotine dependence
eLife, 2015 A great deal of interest has been focused recently on the habenula and its critical role in aversion, negative-reward and drug dependence. Using a conditional mouse model of the ACh-synthesizing enzyme choline acetyltransferase (Chat), we report that ...
Silke Frahm +5 more
doaj +1 more source
Alzheimer’s Disease, Hearing Loss, and Deviance Detection
Frontiers in Neuroscience, 2022 Age-related hearing loss is a widespread condition among the elderly, affecting communication and social participation. Given its high incidence, it is not unusual that individuals suffering from age-related hearing loss also suffer from other age ...
David Pérez-González +9 more
doaj +1 more source
Enteric dysfunctions in experimental Parkinson's disease: alterations of excitatory cholinergic neurotransmission regulating colonic motility in rats [PDF]
, 2016 Parkinson's disease (PD) is frequently associated with gastrointestinal symptoms, mostly represented by constipation and defecatory dysfunctions.
Al Harraq, Zainab +14 more
core +1 more source
Cell type-specific long-range connections of basal forebrain circuit
eLife, 2016 The basal forebrain (BF) plays key roles in multiple brain functions, including sleep-wake regulation, attention, and learning/memory, but the long-range connections mediating these functions remain poorly characterized.
Johnny Phong Do +10 more
doaj +1 more source
Pro-cognitive drug effects modulate functional brain network organization
Frontiers in Behavioral Neuroscience, 2012 Previous studies document that cholinergic and noradrenergic drugs improve attention, memory and cognitive control in healthy subjects and patients with neuropsychiatric disorders.
Carsten eGiessing, Christiane M Thiel
doaj +1 more source
Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission in C. elegans [PDF]
, 2019 Mutations in pre-synaptic voltage gated calcium channels can lead to familial hemiplegic migraine type 1 (FHM1). While mammalian studies indicate that the migraine brain is hyperexcitable due to enhanced excitation or reduced inhibition, the molecular ...
Alkema, Mark J. +9 more
core +1 more source
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild‐to‐moderate Alzheimer's disease (AD) on background donepezil 10 mg/day.
Pradeep J. Nathan +14 more
doaj +1 more source
Plants, 2022 Hesperidin (HSP) is a major flavanone glycoside in citrus fruits, including sweet oranges and lemons. It demonstrates numerous pharmacological activities, such as antihypertensive effects and cardiac and kidney tissue protection.
Priscila de Souza +5 more
doaj +1 more source
Cholinergic system changes of falls and freezing of gait in Parkinson's disease
Annals of Neurology, 2019 Postural instability and gait difficulties (PIGDs) represent debilitating disturbances in Parkinson's disease (PD). Past acetylcholinesterase positron emission tomography (PET) imaging studies implicate cholinergic changes as significant contributors to ...
N. Bohnen +7 more
semanticscholar +1 more source