Results 101 to 110 of about 129,516 (303)

Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy

The Anatomical Record, Volume 309, Issue 2, Page 417-450, February 2026.
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna, Donald B. Hoover, Logan G. Kirkland, Elizabeth H. Smith, Megan D. Poston, Stanley G. Peirce, Chloe G. Garbe, Tasha K. Phillips, Steven Cha, Shumpei Mori, Jaclyn A. Brennan, John Andrew Armour, Eric Rytkin, Igor R. Efimov, Olujimi A. Ajijola, Jeffrey L. Ardell, Kalyanam Shivkumar   +16 more
wiley   +1 more source

The identification of novel missense variant in ChAT gene in a patient with gestational diabetes denotes plausible genetic association

Open Medicine
Gestational diabetes mellitus (GDM), the most common metabolic complication of pregnancy, is associated with a 50% increase in subsequent risk for type 2 diabetes.
Oluwole Oluwafemi G., Arowolo Afolake, Musa Ezekiel, Levitt Naomi, Matjila Mushi   +4 more
doaj   +1 more source

RVLM C1 Neurons Innervate Sacral as well as Thoracolumbar Autonomic Preganglionic Neurons in the Rat

Journal of Comparative Neurology, Volume 534, Issue 2, February 2026.
Axons expressing the adrenaline‐synthesizing enzyme, phenylethanolamine N‐methyltransferase (PNMT), project widely throughout the spinal cord. Many of these axons are from C1 neurons of the rostral ventrolateral medulla. We confirm that dense arrays of PNMT‐expressing, C1‐derived axons surround thoracolumbar sympathetic preganglionic neurons, many of ...
I. J. Llewellyn‐Smith, L. Travis, A. A. Connelly, J. K. Bassi, C. Menuet, A. M. Allen   +5 more
wiley   +1 more source

Effects of Ginkgo biloba Extract EGb 761, Donepezil and their Combination on Central Cholinergic Function in Aged Rats

Journal of Pharmacy & Pharmaceutical Sciences, 2015
Purpose. Ginkgo extract EGb 761 and cholinesterase inhibitors have been shown to be effective in the treatment of dementia patients. In addition to neuroprotective effects, Ginkgo extract EGb 761 has been reported to elevate brain levels of certain ...
Christoph Stein, Julia Hopfeld, Helene Lau, Jochen Klein   +3 more
doaj   +1 more source

Neuro‐Immune Crosstalk: Molecular Mechanisms, Biological Functions, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo, Hui Liu, Yu‐Jing Song, Jian‐Hua Wang, Danfeng Liu, Zhi‐Wei Zheng, Jia‐Jun Li, Boya Li, An Song, Wei He, Lei‐Lei Yang, Shuo Wang   +11 more
wiley   +1 more source

Regulated peristalsis into the acidic region of the _Drosophila_ larval midgut is controlled by a novel component of the Autonomic Nervous System [PDF]

, 2009
The underlying cellular and molecular mechanisms that regulate and coordinate critical physiological processes such as peristalsis are complex, often cryptic, and involve the integration of multiple tissues and organ systems within the organism.
Brooke Ann Johnson, Dennis Richard LaJeunesse, Grzegorz Zapotoczny, Jason Presnell, Kathleen K. Catignas   +4 more
core   +1 more source

Altered expression of Alzheimer's disease-related proteins in male hypogonadal mice [PDF]

, 2012
Age-related depletion of estrogens and androgens is associated with an increase in Alzheimer's disease (AD) brain pathology and diminished cognitive function. Here we investigated AD-associated molecular and cellular changes in brains of aged hypogonadal
Drummond, E.S., Handelsman, D.J., Harvey, A.R., Martins, R.N.   +3 more
core   +2 more sources

Hepatic CD4 T Cells Predict Hepatocellular Carcinoma Risk on Metabolic Dysfunction‐Associated Steatohepatitis Patients

United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.
ABSTRACT Background & Aims Metabolic dysfunction‐associated steatohepatitis (MASH) increasingly drives hepatocellular carcinoma (HCC) development. We characterized inflammatory infiltrates in liver biopsies from MASH patients who developed HCC versus controls to identify predictive immune signatures. Method Formalin‐fixed paraffin‐embedded (FFPE) liver
Emilse Rodriguez, Peter Simon, Sabrina Dhooge, Marina Fernandez, Patricia Calafat, María Kurpis, Nicolás Nuñez, Jhon Prieto, Anna Saborowski, Arndt Vogel, José Daniel Debes, Domingo Cesar Balderramo, Andre Boonstra, Pablo Alberto Romagnoli   +13 more
wiley   +1 more source

Data on retinoic acid and reduced serum concentration induced differentiation of Neuro-2a neuroblastoma cells

Data in Brief, 2018
The present data describe the relative neuro-2a cellular differentiation induced by reducing serum concentration (0.1% FBS) in DMEM in the presence/absence of 20 μM retinoic acid (RA).
Mukesh Kumar, Anju Katyal
doaj   +1 more source

Human tenocytes are stimulated to proliferate by acetylcholine through an EGFR signalling pathway [PDF]

, 2012
Studies of human patellar and Achilles tendons have shown that primary tendon fibroblasts (tenocytes) not only have the capacity to produce acetylcholine (ACh) but also express muscarinic ACh receptors (mAChRs) through which ACh can exert its effects. In
Alexander Scott, Gloria Fong, Gustav Andersson, Ludvig J. Backman, Patrik Danielson   +4 more
core   +1 more source