Results 121 to 130 of about 129,516 (303)

Elevated mRNA-levels of distinct mitochondrial and plasma membrane Ca2+ transporters in individual hypoglossal motor neurons of endstage SOD1 transgenic mice.

Frontiers in Cellular Neuroscience, 2014
Disturbances in Ca2+ homeostasis and mitochondrial dysfunction have emerged as major pathogenic features in familial and sporadic forms of Amyotrophic Lateral Sclerosis (ALS), a fatal degenerative motor neuron disease. However, the distinct molecular ALS-
Tobias eMühling, Johanna eDuda, Jochen eWeishaupt, Albert C. Ludolph, Birgit eLiss   +4 more
doaj   +1 more source

Altered Inflammatory Signature in a C9ORF72 ‐ALS iPSC‐Derived Motor Neuron and Microglia Coculture Model

Glia, Volume 74, Issue 1, January 2026.
Established a C9ORF72 ALS microglia and motor neuron coculture model. Identified an altered inflammatory signature in C9ORF72 ALS microglia. Single‐cell RNA sequencing detected the removal of an LPS responsive microglia subpopulation. ABSTRACT Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disorder involving multiple cell types in ...
Yujing Gao, Jessica L. Brothwood, Harpreet Saini, Gregory A. O'Sullivan, Carla F. Bento, James M. McCarthy, Nicola G. Wallis, Elena Di Daniel, Brent Graham, Daniel M. Tams   +9 more
wiley   +1 more source

Improvement of Cognitive Function in Ovariectomized Rats by Human Neural Stem Cells Overexpressing Choline Acetyltransferase via Secretion of NGF and BDNF. [PDF]

Int J Mol Sci, 2022
Yoon EJ, Choi Y, Park D.
europepmc   +1 more source

Muscle-derived factors that support survival and promote fiber outgrowth from embryonic chick spinal motor neurons in culture [PDF]

, 1986
The purpose of the experiments reported is to provide an unambiguous demonstration that embryonie skeletal muscle contains factors that act directly on embryonie spinal motor neurons both to support their survival and to stimulate the outgrowth of ...
Dohrmann, Ulrike, Edgar, David, Sendtner, Michael, Thoenen, Hans   +3 more
core  

Effects of gastrointestinal motility on obesity [PDF]

, 2014
Background: Changes of gastrointestinal motility, which are important related to the food digestion and absorption in the gastrointestinal tract, may be one of the factors in obesity-formation.
Fu, Xiao-Yi, Li, Ze, Liu, Jia-Ren, Wang, Shu-Ran, Yu, Hai-Tao, Zhang, Na   +5 more
core   +2 more sources

Muscarinic Binding and Choline Acetyltransferase in Postmortem Brains of Demented Patients [PDF]

, 1986
Steven B. Waller, Melvyn J. Ball, Mark A. Reynolds, Edythe D. London   +3 more
openalex   +1 more source

JAK Inhibitors and Memory Impairment: Disproportionality Analyses in the WHO Global Pharmacovigilance Database, VigiBase

Fundamental &Clinical Pharmacology, Volume 40, Issue 1, January 2026.
ABSTRACT Background Chronic inflammation is involved in various mechanisms of memory impairment (MI). Although Janus kinase inhibitors (JAKi), which inhibit cytokine‐induced JAK–STAT pathway, could theoretically protect against MI, we faced an unexpected case of MI in a non‐elderly patient treated with JAKi.
Marilou Duboëlle, Adriano Lercara, Yves‐Marie Pers, Céline Michel, Marion Lepelley, Marie‐Blanche Valnet‐Rabier, Jean‐Luc Faillie, Virginie Bres, Pascale Palassin   +8 more
wiley   +1 more source

Immunohistochemical demonstration of specific antigens in the human brain fixed in zinc-ethanol-formaldehyde

European Journal of Histochemistry, 2015
Tissue fixation is critical for immunohistochemistry. Recently, we developed a zinc-ethanol-formalin fixative (ZEF), and the present study was aimed to assess the applicability of the ZEF for the human brain histology and immunohistochemistry and to ...
D.E. Korzhevskii, E.G. Sukhorukova, O.V. Kirik, I.P. Grigorev   +3 more
doaj   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

Choline Acetyltransferase Induces the Functional Regeneration of the Salivary Gland in Aging SAMP1/Kl -/- Mice. [PDF]

Int J Mol Sci, 2021
Toan NK, Tai NC, Kim SA, Ahn SG.
europepmc   +1 more source