Results 181 to 190 of about 110,287 (267)
Establishing a 3D Spheroid Model of Cholinergic Neurons from SH-SY5Y Cells for Neurotoxicity Assessment. [PDF]
Toxins (Basel)Franco-Campos F +3 more
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Regulation of mild moxibustion on non-neuronal cholinergic system in ulcerative colitis rats. [PDF]
J Tradit Chin MedGuangbin P +10 more
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Activation of Choline Acetyltransferase by Salts [PDF]
Nature New Biology, 1971 IONIZED salts affect choline acetyltransferase, EC 2.3.1.6 (ChA), in two important ways. They change the equilibrium between soluble and membrane-bound ChA, in preparations of ruptured nerve endings1,2. Further, the rate of synthesis of acetylcholine by soluble ChA and the Michaelis constants for this reaction depend on the concentration of salts3. The
A. K. Prince +3 more
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CRC Critical Reviews in Biochemistry, 1977
Acetylcholine is essential to neural function. It synthesis is catalyzed by choline acetyltransferase, the enzyme responsible for the acetylation of choline by acetyl coenzye A, a reaction favored slightly thermodymodynamically and not at all kinetically. An analytically pure enzyme still has not been obtained; however, method of purification have been
Henry G. Mautner, David Nachmansohn
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Acetylcholine is essential to neural function. It synthesis is catalyzed by choline acetyltransferase, the enzyme responsible for the acetylation of choline by acetyl coenzye A, a reaction favored slightly thermodymodynamically and not at all kinetically. An analytically pure enzyme still has not been obtained; however, method of purification have been
Henry G. Mautner, David Nachmansohn
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Choline acetyltransferase in schizophrenia
American Journal of Psychiatry, 1993To test the hypothesis that schizophrenia involves altered cholinergic tone in the pons, the authors studied post-mortem brain tissue from subjects with schizophrenia.The authors used Western immunoblot to measure the concentration of choline acetyltransferase, an acetylcholine synthesizing enzyme, in the post-mortem brain tissue of 25 schizophrenic ...
C. N. Karson +3 more
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The phosphorylation of choline acetyltransferase
Neurochemical Research, 1989Human placental Choline Acetyltransferase (ChAT) has been shown to be phosphorylated in vitro by kinases present in rat brain. Phosphorylation occurs at a single site with the exclusive phosphoamino acid being serine. ChAT phosphorylation was shown to be calcium, and not cyclic nucleotide, dependent and was inhibited by inhibitors of calcium/calmodulin
Louis B. Hersh, Gordon Bruce
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Differential assay for choline acetyltransferase
Analytical Biochemistry, 1974Abstract A rapid and sensitive radiochemical assay for choline acetyltransferase (EC 2.3.1.6) is reported. The assay allows for the fact that during incubation of [ 14 C]acetyl-CoA and choline with a cell homogenate, at least one product is formed besides [ 14 C]acetylcholine, which passes an anion exchange column. In contrast to [ 14 C]acetylcholine,
Takehiko Amano, Bernd Hamprecht
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Immunohistochemistry of Choline Acetyltransferase
1979Publisher Summary This chapte discusses the problems related to immunohistochemistry of choline acetyltransferase (ChAT)-containing systems in the brain and spinal cord. The synthetic enzyme ChAT is a definitive marker for cholinergic neurons and their processes.
Patrick L. McGeer +3 more
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Choline acetyltransferase in the snail brain
Comparative and General Pharmacology, 1970Abstract 1. 1. Choline acetyltransferase was detected and measured in Helix pomatia suboesophageal ganglia. 2. 2. The highest level of activity was observed at 35°C. and p H 7·5.
B. Powell, G.A. Cottrell
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