Results 11 to 20 of about 17,945 (232)
Chaperone-Mediated Regulation of Choline Acetyltransferase Protein Stability and Activity by HSC/HSP70, HSP90, and p97/VCP [PDF]
Frontiers in Molecular Neuroscience, 2017 Choline acetyltransferase (ChAT) synthesizes the neurotransmitter acetylcholine in cholinergic neurons, and mutations of this enzyme are linked to the neuromuscular disorder congenital myasthenic syndrome (CMS).
Trevor M. Morey +7 more
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Correction: Perinatal Choline Supplementation Reduces Amyloidosis and Increases Choline Acetyltransferase Expression in the Hippocampus of the APPswePS1dE9 Alzheimer's Disease Model Mice. [PDF]
PLoS ONE, 2017 [This corrects the article DOI: 10.1371/journal.pone.0170450.].
Tiffany J Mellott +6 more
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Frontiers in Physiology, 2023 Prostatic acid phosphatase (PAP) exists as two splice variants, secreted PAP and transmembrane PAP, the latter of which is implicated in antinociceptive signaling in dorsal root ganglia.
Peter J. Hanley
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Molecules, 2022 Aim: A monoterpene and bioactive component of the plant Rhodiola rosea (R. rosea), rosiridin has beneficial effects on the human central nervous system and enhances brain function.
Muhammad Afzal +7 more
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Current Issues in Molecular Biology, 2021 Postmenopausal syndrome refers to symptoms caused by the gradual decrease in female hormones after mid-40 years. As a target organ of estrogen, decrease in estrogen causes various changes in brain function such as a decrease in choline acetyltransferase ...
Gaeul Han +8 more
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On the Mechanism of Action of Choline Acetyltransferase [PDF]
Proceedings of the National Academy of Sciences, 1974 The substrate specificity of choline acetyltransferase (EC 2.3.1.6) isolated from squid ganglia was investigated. The enzyme catalyzed the acetylation of choline and aminocholine but not of homocholine. In D 2 O solution there was considerable slowing of the transacetylation reaction. Photo-oxidation in the presence
Stephen F. Currier, Henry G. Mautner
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CXCL12 Regulates the Cholinergic Locus and CHT1 Through Akt Signaling Pathway
Cellular Physiology and Biochemistry, 2016 Background: CXCL12 is pivotal for cholinergic neurons, and it induces the expressions of several genes that are essential for synthesis and storage of acetylcholine(ACh), specifically choline acetyltransferase, vesicular ACh transporter (VAChT), and ...
Jing Yan +4 more
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Effects of Goldblatt hypertension on rats’ hippocampal cholinergic system
Translational Neuroscience, 2022 The classical renin-angiotensin system (RAS) has an important role in the cardiovascular system and water homeostasis in the body. Recently, the existence of RAS with all of its components has been shown in the mammalian brain.
Sepehri Hamid +3 more
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Molecules, 2016 In the present study, we examined the ameliorating effects of demethoxycurcumin (DMC) on memory impairment induced by scopolamine using passive avoidance and Morris water maze tests in mice.
Dong Wook Lim +6 more
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Cell Transplantation, 2001 In Alzheimer's disease cholinergic neurons degenerate, resulting in loss of hippocampal acetylcholine. The fimbria-fornix aspiration is a well-known animal model mimicking hippocampal cholinergic deficiency.
Carla Weis +2 more
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